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2021, Number 4

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Revista Cubana de Salud Pública 2021; 47 (4)

Sexual and reproductive health in times of COVID-19

Monteagudo PG, Cabrera GM, Ovies CG, Rodríguez PB

Language: Spanish
References: 49
Page: 1-16
PDF size: 552.74 Kb.


ABSTRACT

Introduction: The pandemic unleashed from the rapid expansion of the SARS-CoV-2 coronavirus and its high contagiousness and the lethality of the COVID-19 disease, which results from it, has had a profound impact on all spheres of human existence, including those related to sexual and reproductive health.
Objective: Identify the effects of COVID-19 on sexual and reproductive health in times of pandemic.
Methods: The electronic databases, Google Scholar, Pubmed central, LILACS, BIREME, SciELO Regional, which were accessed through Google search engine were reviewed, and Infomed portal was also reviewed. 94 bibliographic sources were identified, of which 45 were excluded.
Conclusions: Data on the impact of COVID-19 on sexual and reproductive health are scarce and there are still questions not fully clarified. The evidence on transmission by semen or feces is contradictory and does not seem to be transmitted by vaginal secretions, but saliva or sexual intimacy can be a source of contagion, so the need to maintain responsible sexual behavior is recommended. There is a theoretical possibility of testicular damage and possible infertility after SARS-COV-2 infection, for which further studies are needed. Information on its possible effect on the female reproductive system is insufficient.


REFERENCES

  1. Who.int. Orientaciones técnicas de la OMS para el control y la prevención de las infecciones en el contexto de la COVID-19. Ginebra: WHO; 2019 [actualizado 15/08/2020; acceso 17/10/2020]. Disponible en: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/infection-prevention-and-control.

  2. Alhazzani W, Moller MH, Arabi YM, Loeb M, Gong MN, Fan E. Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19). Intensive Care Med. 2020 [acceso 11/10/2020];46(5):854-87. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101866/.

  3. Asid.net.au Australia: ASID. Interim guidelines for the clinical management of COVID-19 in adults; 2020 [actualizado 14/08/2020; acceso 17/10/2020]. Disponible en: https://www.asid.net.au/documents/item/1873.

  4. Hindson J. COVID-19: faecal-oral transmission? Nat Rev Gastro enteral Hepatol. 2020;17(5):259. DOI: 10.1038/s41575-020-0295-7

  5. Xiao F, Tang M, Zheng X, Liu Y, Li X, Shan H. Evidence for Gastrointestinal Infection of SARS-CoV-2. Gastroenterology. 2020;158(6):1831-3. DOI: 10.1053/j.gastro.2020.02.055

  6. Herrera EL. 9 respuestas para vivir en pareja en tiempos de COVID-19 más PDF. Rev Juvent Tec. 2020 [acceso 17/10/2020] Disponible en: http://www.juventudtecnica.cu/contenido/9-claves-vivir-pareja-tiempos-covid-19-mas-pdf.

  7. Lu H, Stratton C, Tang Y. Outbreak of pneumonia of unknown etiology in Wuhan, China: the mystery and the miracle. J Med Virol. 2020;92:401-2. DOI: 10.1002/jmv.25678

  8. Wang L, Wang Y, Ye DW, Liu QQ. A review of the 2019 Novel Coronavirus (COVID-19) based on current evidence. Int J Antimicrob Agents 2020;55(6):105948. DOI: 10.1016/j.ijantimicag.2020.105948

  9. Kakodkar P, Kaka N, Baig MN. A Comprehensive Literature Review on the Clinical Presentation, and Management of the Pandemic Coronavirus Disease 2019 (COVID-19). Cureus 2020;12(4):2-18. DOI: 10.7759/cureus.7560

  10. Who. int. Coronavirus disease (COVID-2019) situation reports. Ginebra: WHO; 2019 [actualizado 21/03/2020; acceso 22/09/2020]. Disponible en: https://www.who.int/emergencies/diseases/novel-coronavi2019/situation-reports

  11. Nextstrain.org. USA: Phylogeny of SARS-like betacoronaviruses including novel coronavirus SARS-CoV-2; 2020 [actualizado 28/04/2020; acceso 22/09/2020]. Disponible en: https://nextstrain.org

  12. Song W, Gui M, Wang X, Xiang Y. Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2. PLOS Pathog. 2018;14(8). DOI: 10.1371/journal.ppat.1007236

  13. Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature.2020;579:270-3. DOI: 10.1038/s41586-020-2012-7

  14. Eisenberg M. Coronavirus Disease 2019 (COVID-19) and men's reproductive health. Fertil Steril. 2020;113(6):1154. DOI: 10.1016/j.fertnstert.2020.04.039

  15. Nanshan C, Zhou M, Xuan D, Jieming Q, Fengyun G, Yang H, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020 [acceso 22/09/2020];395:507-13. Disponible en: https://n9.cl/n4aeb

  16. Li W, Shi Z, Yu M, Ren W, Smith C, Epstein JH, et al. Bats are natural reservoirs of SARS-like coronaviruses. Science. 2005;310:676-9.

  17. Zhang T, Wu Q, Zhang Z. Probable pangolin origin of SARS-CoV-2 associated with the COVID-19 outbreak. Curr Biol. 2020;30(7):1346-51. DOI: 10.1016/j.cub.2020.03.022

  18. Cui J, Li F, Shi Z-L. Origin and evolution of pathogenic coronaviruses. Nat Rev Microbiol. 2019;17(3):181-92. DOI: 10.1038/s41579-018-0118-9

  19. Xu H, Zhong L, Deng J, Peng J, Dan H, Zeng X, et al. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. Int J Oral Sci. 2020;12(1):8. DOI: 10.1038/s41368-020-0074-x

  20. Pan L, Mu M, Yang P, Sun Y, Wang R, Yan J, et al. Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: a descriptive, cross-sectional, multicenter study. Am J Gastroenterol. 2020;115(5):766-73. DOI: 10.14309/ajg.0000000000000620

  21. Hussein J. COVID-19: What implications for sexual and reproductive health and rights globally?Sex Reprod Health Matters. 2020;28(1):1-3. DOI: 10.1080/26410397.2020.1746065

  22. Salam AP, Horby PW. The Breadth of Viruses in Human Semen. Emerg Infect Dis. 2017;23(11):1922-4. DOI: 10.3201/eid2311.171049

  23. Shereena MA, Khana S, Kazmic A, Bashira N, Siddique R. COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses. J Adv. Res. 2020;24:91-8. DOI: 10.1016/j.jare.2020.03.005

  24. Li D, Jin M, Bao P, Zhao W, Zhang S. Clinical Characteristics and Results of Semen Tests Among Men With Coronavirus Disease 2019. JAMA Netw Open. 2020;3(5):e208292. DOI: 10.1001/jamanetworkopen.2020.8292

  25. Fen P, Xiao X, Guo J, Song Y, Li H, Patel D. No evidence of SARS-CoV-2 in semen of males recovering from COVID-19. Fertil Steril. 2020;113(6):1135-9. DOI: 10.1016/jfertnstert.2020.04.024

  26. Paoli D, Pallotti F, Colangelo S, Basilico F, Mazzuti L, Turriziani O, et al. Study of SARS-CoV-2 in semen and urine samples of a volunteer with positive nasopharyngeal swab. J Endocrinol Invest. 2020;23:1-4. DOI: 10.1007/s40618-020-01261-1

  27. Liu Y, Yan L, Wan L, Xiang T, Le A, Liu Z. Viral dynamics in mild and severe cases of COVID-19. Lancet Infect Dis. 2020;20(6):656-7. :DOI: 10.1016/S1473-3099(20)30232-2..

  28. Qiu L, Liu X, Xiao M, Xie J, Cao W, Liu Z. SARS-CoV-2 Is Not Detectable in the Vaginal Fluid of Women With Severe COVID-19 Infection. Clin Infect Dis 2020;71(15):813-7. DOI: 10.1093/cid/ciaa375

  29. Cui P, Chen Z, Wang T, Dai J, Zhang J, Ding T, et al. Clinical features and sexual transmission potential of SARS-CoV-2 infected female patients: a descriptive study in Wuhan, China. medRxiv. 2020.02.26.20028225. DOI: 10.1101/2020.02.26.20028225

  30. Panzeri M, Ferrucci R, Cozza A, Fontanesi L. Changes in Sexuality and Quality of Couple Relationship During the COVID-19 Lockdown. Front Psychol. 2020;11:565823. DOI: 10.3389/fpsyg.2020.565823

  31. Abobaker A, Raba A. Does COVID-19 affect male fertility? World J Urol. 2020;21:1-2. DOI: 10.1007/s00345-020-03208-w

  32. Wang Z, Xu X. scRNA-seq Profiling of Human Testes Reveals the Presence of ACE2 Receptor, a Target for SARS-CoV-2 Infection, in Spermatogonia,Leydig and Sertoli. Cells. 2020;(4):920-9. DOI: 10.3390/cells9040920

  33. Shen Q, Xiao X, Aierken A, Liao M, Hua J. The ACE2 expression in Sertoli cells and germ cells may cause male reproductive disorder after SARS-CoV-2 infection. Cell Mol Med. 2020;24(16):9472-7. DOI: 10.1111/jcmm.15541

  34. Song C, Wang Y, Li W, Hu B, Chen G, Xia P, et al. Detection of 2019 novel coronavirus in semen and testicular biopsy specimen of COVID-19 patients. MedRxiv 2020.03.31.20042333. DOI: 10.1101/2020.03.31.20042333

  35. Ma L, Xie W, Li D, Shi L, Mao Y, Xiong Y, et al. Effect of SARS-CoV-2 infection upon male gonadal function: A single center-based study. MedRxiv. 2020.03.21.20037267; DOI: 10.1101/2020.03.21.20037267

  36. Jung A, Schuppe HC. Influence of genital heat stress on semen quality in humans. Androl. 2007;39(6):203-15. DOI: 10.1111/j.1439-0272.2007.00794.x

  37. Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020;181(2):271-80. DOI: 10.1016/j.cell.2020.02.052

  38. Li R, Yin T, Fang F, Li Q, Chen J, Wang Y, et al. Potential risks of SARS-Cov-2 infection on reproductive health Reprod Biomed Online. 2020;41(1):89-95. DOI: 10.1016/j.rbmo.2020.04.018

  39. Zhang J, Wu Y, Wang R, Lu K, Tu M, Guo H, et al. Bioinformatic Analysis Reveals That the Reproductive System is Potentially at Risk from SARS-CoV-2. Preprints 2020. DOI: 10.20944/preprints202002.0307.v1

  40. Reis F, Bouissou D, Pereira V, Camargos A, dos Reis A, Santos R. Angiotensin-(1-7), its receptor Mas, and the angiotensin-converting enzyme type 2 are expressed in the human ovary. Fertil Steril. 2011;95(1):176-81. DOI: 10.1016/j.fertnstert.2010.06.060

  41. FIGO: International Federation of Gynecology and Obstetrics. Fertility Treatment and COVID-19. EE. UU.: FIGO; 2020. [acceso 30/03/2020]. Disponible en: https://www.figo.org/fertility-treatment-and-covid-19

  42. START: Society for Assisted Reproductive Tecnology. SART and ASRM issue advice for infertility patients concerning the novel coronavirus (COVID-19). EE. UU.: STAR; 2020 [acceso 20/02/2020]. Disponible en: https://n9.cl/eh9se43

  43. Barañao RI. Hormonas sexuales y respuesta inmunológica. Bioreview. 2009;13(8):24-44.

  44. León EJ, Toirac NM, Navarro D. Déficit de estrógeno e inmunidad, una aproximación sugerente a la mujer posmenopáusica. Rev Cub Endocrinol. 2015 [acceso 22/09/2020];26(3):292-303. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1561-29532015000300009&Ing=es

  45. Driggin E, Madhavan MV, Bikdeli B, Chuich T, Laracy J, Bondi-Zoccai G, et al. Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the Coronavirus Disease 2019 (COVID-19) Pandemic. J Am Coll Cardiol. 2020;75(18):2352-71. DOI: 10.1016/j.jacc.2020.03.031

  46. Tang N, Bai H, Chen X, Gong J, Li D, Sun Z. Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy. J Thromb Haemost. 2020;18(5):1094-9. DOI: 10.1111/jth.14817

  47. Ramírez I, De la Viuda E, Baquedano L, Coronado P, Llaneza P, Mendoza N, et al. Managing thromboembolic risk with menopausal hormone therapy and hormonal contraception in the COVID-19 pandemia. Maturitas. 2020;137:57-62. DOI: 10.1016/j.maturitas.2020.04.019

  48. Wang J, Hajizadeh N, Moore EE, McIntyre RC, Moore PK, Veress LA, et al. Tissue Plasminogen Activator (tPA) Treatment for COVID-19 Associated Acute Respiratory Distress Syndrome (ARDS): A Case Series. J Thromb Haemost. 2020;18(7):1752-5. DOI: 10.1111/jth.14828

  49. Lekovic D, Miljic P, Dmitrovic A, Thachil J. How do you decide on hormone replacement therapy in women with risk? Blood Rev. 2017;31(3):151-7. DOI: 10.1016/jblre.2016.12.001




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