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2021, Number 4

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Rev Cubana Pediatr 2021; 93 (4)

Lung microbiota and the gut-lung axis

Castañeda GC

Language: Spanish
References: 46
Page: 1-16
PDF size: 627.45 Kb.


ABSTRACT

Introduction: In the light of the most recent knowledge, it is important to emphasize the potential role played by the gut microbiota, through the gut-lung axis, with the lung microbiota.
Objective: Update the criteria about the lung microbiota in healthy subjects and its relationship with the gut-lung axis.
Methods: Publications in Spanish and English were reviewed in PubMed, Google Scholar, ScIELO, from January 2010 to May 2020; the following terms were used: lung microbiota, lower respiratory tract microbiota, gut-lung axis, lung microbiota and immunity and next- generation probiotics.
Analysis and integration of information: Arguments related to the presence of commensal microbiota resident in the lung formed by bacteria, fungi and viruses as members of the microbial community are presented. Role of the gut-lung axis and its participation in immune modulation. Features of the lung microbiota, its biomass, diversity, and component phylums are described. Researches in animals are summarized. The value of the new 16S gene sequencing technology of rRNA for study and identification is highlighted.
Final considerations: The lung was considered a sterile organ. Here the presence of resident commensal microbiota of great diversity in the lung is documented; the mechanisms of the gut-lung axis and its role in the modulation of lung immunity and diagnostic value in diseases of the lower respiratory tract are stated. The future use of next-generation probiotics as modulators of the lung microbiota is emphasized.


REFERENCES

  1. Castañeda C. Microbiota intestinal y los primeros 1000 días de vida. Rev. Cuban. pediatr. 2021 [acceso 3/7/2021];93(3):e1382. Disponible en: Disponible en: http://www.revpediatria.sld.cu/index.php/ped/article/view/1382/823

  2. Castañeda C. La Microbiota intestinal. Capítulo 2. En: Microbiota intestinal humana y sus desafíos. Quito: Ed. El Siglo; 2020.

  3. Moffatt MF, Cookson WO. The lung microbiome in health and disease. Clin Med (Lond). 2017;17(6):525-529. DOI: 10.7861/clinmedicine.17-6-525.

  4. Frati F, Salvatori C, Incorvaia C, Bellucci A, Di Cara G, Mercucci F, et al. The role of the microbiome in asthma: The Gut-Lung Axis. Int J Mol Sci. 2019;20(1):123. DOI: 10.3390/ijms20010123.

  5. Valverde-Molina J, Valverde-Fuentes J. La disbiosis microbiana como origen precoz del asma. Rev Asma. 2018 [acceso: 16/04/2020];3(2):36-45. Disponible en: Disponible en: https://www.separcontenidos.es/revista3/index.php/revista/article/view/138/185

  6. Turnbaugh PJ, Ley RE, Hamady M, Fraser-Liggett CM, Knight R, Gordon JI. El proyecto del microbioma humano. Nature. 2007;449:804-10. DOI: 10.1038/nature06244.

  7. Andréjak C, Delhaes L. The lung microbiome 2015; a window on chronic lung diseases. Med Sci (Paris). 2015;31(11):971-8. DOI: https://doi.org/10.1051/medsci20153111011. Epub 2015 17 de noviembre.

  8. Schenck LP, Surette MG, Bowdish ME. Composition and immunological significance often upper respiratory tract microbiota. FEBS Lett 2016;590(21):3705-20. DOI: https://doi.org/10.1002/1873-3468.12455.

  9. Yun Y, Srinivas G, Kuenzel S, Linnenbrick M, Alnahas S, Bruce KD, et al. Environmentally determined differences in the murine lung microbiota and the relation to alveolar architecture. PLoS One. 2014:e113466. DOI: https://doi.org/10.1371/journal.pone.0113466

  10. Hilty M, Burke C, Pedro H, Cárdenas P, Bush A, Bossley C, et al. Disordered microbial commuities in asthmatic airways. Plos One. 2020;5(1):e8578. DOI: 10.1371/journal.pone.0008578.

  11. Dumas A, Bernard L, Poquet Y, Lugo-Villarino G, Neyrolles O. The role of the lungs and the gut-lung axis in respiratory infectious diseases. Cell Microbiol. 2018;20(12):e12966. DOI: https://doi.org/10.1111/cmi. Epub 2018 Oct 30.

  12. Budden KF, Gellatly SL, Wood DL, Cooper MA, Morrison M, Hugenholtz P, et al. Emerging pathogenic links between microbiota and the gut‐lung axis. Nature Rev Microbiol. 2017;15:55-63. DOI: https://doi.org/10.1038/nrmicro.2016.142.

  13. Enaud R, Prevel R, Ciarlo E, Beaufils F, Wieers G, Guery B, et al. The gut-lung axis in health and respiratory disease: a place for inter-organ and inter-kingdom cross talks. Front Microbiol. 2020:10.3389. DOI: https://doi.org/10.3389/fcimb.2020.00009.

  14. Soret P, Vandenborght LE, Francis F, Coron N, Enaud R, Avalos M, et al. Respiratory mycobiome and suggestion of inter-The microbiome in the lower respiratory tract. Sci Rep. 2020;10(1):3589. DOI: 10.1038/s41598-020-60015-4.

  15. Martin CR, Osadchiy V, Kalani A, Mayer EA. The brain-gut microbiota axis. Cell Mol Gastroenterol Hepatol. 2018:133-148. DOI: 10.1016/j.jcmgh.2018.04.003.

  16. Bingula R, Filaire M, Radosevic-Robin N, Bey M, Berthon J-I, Bernalier-Donadille A. et al. Desired turbulence? Gut-lung axis, immunity, and lung cancer. J Oncol. 2017:10:1155. DOI: https://doi.org/10.1155/2017/5035371.

  17. García-Pachín E. La microbiota de la vía aérea inferior. Med Resp. 2017 [acceso 07/05/2020];10(1):29-35. Disponible en: Disponible en: http://www.neumologiaysalud.es/descargas/R10/R10-4.pdf

  18. Dickson RP, Downward JR, Falkowski NR, Hunter EM, Ashley SL, Huffnagle GB. The lung microbiota of healthy mice are highly variable, cluster by environment, and reflect variation in baseline lung innate immunity. Am J Respir Crit Care Med. 2018;198:497-508. DOI: https://doi.org/10.1164/rccm.201711‐2180OC Dickson, R.P

  19. Kostric M, Milger K, Krauss‐Etschmann S, Engel M, Vestergaard G, Schloter M, et al. Development of a stable lung in healthy neonatal mice. Microb Ecol. 2018;75(2):529-54. DOI: 10.1007/s00248-017-1068-x. Epub 2017 Sep 13.

  20. Costa AN, Marques de Costa F, Vidal S, Salles RK, Abensar R. Microbioma pulmonar: desafíos de um novo paradigms. J Bras Pneumol. 2018;44(5):424-42. DOI: https://doi.org/10.1590/s1806-37562017000000209

  21. Faner R, Sibila O, Agustí A, Bernasconi E, Chalmers JD, Huffnagle GB, et al. The microbiome in respiratory medicine: current challenges and future perspectives. Eur Respir J. 2017;49(4).pii: 1602086. DOI: 10.1183/13993003.02086-2016.

  22. Chotirmall SH, Gellatly SL, Budden KF, Mac Aogain M, Shukla SD, Wood DL, et al. Microbiomes in respiratory health disease: An Asia-Pacific Perspect. Respirol. 2017;22(2):240-50. DOI: https://10.1111/resp.12971.

  23. Mitchell AB, Oliver BG, Glanville AR. Transitional aspects of the Human Respiratory Virome. Am J Respir Crit Care Med. 2016;194(12):1458-64. DOI: 10.1016/j.ccm.2016.11.001.

  24. O’Dwyer DN, Dickson RP, Moore B. The lung microbiome, immunity, and the pathogenesis of chronic lung disease. J Immunol. 2016;196(12):4839-4847. DOI: https://doi.org/10.4049/jimmunol.1600279

  25. Man W-H, Steenhuijsen Piters W-AA, Bogaert D. The microbiota of the respiratory tract: gatekeeper to respiratory health. Nat Rev Microbiol. 2017;15(5):259-70. DOI: 10.1038/nrmicro.2017.14.

  26. Ubagsn DJ, Marsland BJ. Mechanistic insight into the function of the microbiome in lung diseases. Eur Resp J. 2017;50:160246. DOI: 10.1183/13993003.02467-2016.

  27. Monsó E. El microbioma respiratorio más allá del cultivo. Arch Bronconeumol. 2017;53(9):473-4. DOI: 10.1016/j.arbres.2016.11.008.

  28. Barfod KK, Roggenbuck M, Hansen LH, Schjorring S, Larsen ST, Sorensen SJ, et al. The murine lung microbiome in relation to the intestinal and vaginal bacterial communities. BMC Microbiol. 2013;13:303. DOI: 10.1186/1471-2180-13-1303.

  29. Remot A, Descamps D, Noordine ML, Boukadiri A, Mathieu E, Robert V, et al. Bacteria isolated from lung modulate asthma susceptibility in mice. ISMEJ. 2017;11:1061-74. DOI: 10.1038/ismej.2016.181.

  30. Neish AS. Mucosal immunity and the microbiome. Ann Am Thorac Soc. 2014;11(Supl. 1): S28-32. DOI: 10.1513/AnnalsATS.201306-161MG.

  31. Scheiermann J, Klinman DM. Three distinct pneumotypes characterize the microbiome of the lung in BALB/cJmice. PLoS One. 2017;2(7):e0180561. DOI: 10.1371/journal.pone.0180561.eCollection2017.

  32. Willis KA, Stewart JD, Ambalayana N. Recent advances in understanding the ecology of the lung microbiota and deciphering the gut-lung axis. Lung Cell Molec Phys 2020;319(4). DOI: https://doi.org/10.1152/ajplung.00360.2020.

  33. Kanmani P, Clua P, Vizoso-Pinto MG, Rodriguez C, Álvarez S, Melnikov M, et al. Respiratory commensal Bacteria Corynebacterium pseudodiphtheriticum improves resistance of Iinfant mice to respiratory syncytial virus and Streptococcus pneumonia superinfection. Front Microbiol. 2017;8:1613. DOI: 10.3389/fmicb.2017.01613.

  34. Glendinning L, Collie D, Wright S, Rutherford KMD, McLachlan G. Comparing microbiotas in the upper aerodigestive and lower respiratory tracts of lambs. Microbiome. 2017;5:45. DOI: 10.1186/s40168-017-0364-5.

  35. Carney SM, Clemente JC, Cox MJ, Dickson RP, Huang YJ, Kitsios GD, et al. Woring Group on Microbiome in Lungs Diseases. Methods in Lung Microbiome Research. Am J Respir Cell Mol Biol. 2020;62(3):283-99. DOI: 10.1165/rcmb.2019-0273TR.

  36. Baumfeld Y, Walfisch A, Wainstock T, Segal I, Sergienko R, Landau D, et al. Elective cesarean delivery at term and the long-term risk for respiratory Morbidity of the off spring. Eur J Pediatr. 2018;177:1653-9. DOI: 10.1007/s00431-018-3225-8. Epub 2018 Aug 8.

  37. Chen G, Chang W-L, Shu B-C, Guo YL, Chiou S-T, Chiang T-I. Associations of caesarean delivery and the occurrence of neurodevelopmental disorders, asthma or obesity in childhood based on Taiwan birth cohort study. BMJ. 2017;7(9). DOI: https://bmjopen.bmj.com/content/7/9/e017086.

  38. Darabi B, Rahmati S, Hafezi Ahmadi MR, Badfar G, Azami M. The association between caesarean section and childhood asthma: an updated systematic review and meta-analysis. Allerg Asthma Clin Immunol. 2019;15(62). DOI: 10.1186/s13223-019-0367-9.

  39. Arumugan M, Falony G, Pelletier E, Paslier E, Yanada E, Mende DR, et al. Enterotypes of the human gut microbiome. Nature. 2011;473(7346):174-80. DOI: 10.1038/nature09944. Epub 2011 Apr 20.

  40. Castañeda C. Microbiota intestinal y obesidad en la infancia. Rev. cuban. pediatr. 2020 [acceso 04/05/2020];92(1):e927. Disponible en: Disponible en: http://revpediatria.sld.cu/index.php/ped/article/view/927/494

  41. Castañeda C. Probióticos de nueva generación. Belice J Med. 2019 [acceso 04/05/2020];8(2):26-32. Disponible en: Disponible en: https://www.bjomed.com/archives

  42. Chang CJ, Lin TL, Tsai YL, Wu TR, Lai WF, Lu CC, et al. Next generation probiotics in disease amelioration. J Food Drug Anal. 2019;27(3):615-22. DOI: 10.1016/j.jfda.2018.12.011.

  43. Castañeda C. Nueva bioterapéutica: Probióticos de próxima generación. Rev cuban. pediatr. 2021 [acceso 3/7/2021];93(1):e1330. Disponible en: Disponible en: http://www.revpediatria.sld.cu/index.php/ped/article/view/1384/689

  44. LiK J, Chen Z, Huang Y, Zhang R, Luan X, Lei T, et al. Dysbiosis of lower respiratory tract microbiome are associated with inflammation and microbial function variety. Respir Res. 2019;20(11):272. DOI: 10.1186/s12931-019-1246-0.

  45. Gómez M, Ramón-Trapero JL, Pérez Martínez L, Bñanco JR. El eje microbiota-intestino-cerebro y sus grandes proyeciones. Rev Neurol. 2019;68(3):111-117. DOI: 10.33588/rn.6803.2018223.

  46. Sherwin E, Dinan TG, Cryan JF. Recent developments in understanding the role of the gut microbiome in brian health and disease. Ann N Y. Acad Sci. 2018:1420(1):5-25. DOI: 10.1111/nyas.13416. Epub 2017 Aug 2.




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