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2023, Number 4

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Rev Mex Anest 2023; 46 (4)

Development of fetal and neonatal pain

Gutiérrez-Román CI

Language: Spanish
References: 26
Page: 251-255
PDF size: 261.06 Kb.


ABSTRACT

Pain is the main symptom reported worldwide, it is the main cause of human suffering. It is considered that for an individual to feel pain, the following must be present: nociceptors, pain neurotransmitters, pathways that carry the stimulus to the brain, the thalamus and connection with the cortex. For a time it was considered that at this stage the nervous system was not mature enough to feel pain, however, there is currently evidence that the fetus has pain; and its presence alters the development of the nervous system. This review provides an updated view of the ontogeny of fetal and neonatal pain.


REFERENCES

  1. Grout R, Thompson-Fleming R, Carroll AE, Downs SM. Prevalence of pain reports in pediatric primary care and association with demographics, body mass index, and exam findings: a cross-sectional study. BMC Pediatrics. 2018;18:363.

  2. IASP. IASP Announces Revised Definition of Pain. (Access 06-02-2022). Available in: https://www.iasp-pain.org/PublicationsNews/NewsDetail.aspx?ItemNumber=10475&navItemNumber=643

  3. Bellieni CV. New insights into fetal pain. Semin Fetal Neonatal Med. 2019;24:101001.

  4. Raffaeli W y Arnaudo E. Pain as a disease: an overview. J of Pain Res. 2017;10:2003-2008.

  5. Raja SN, Carr DB, Cohen M, et al. The revised International Association for the Study of Pain definition of pain concepts, challenges, and compromises. Pain. 2020;161:1976-1982.

  6. Dissanayake DWN y Dissanayake DMD. The physiology of pain: an update and review of clinical relevance. JCCP. 2015;46:19-23.

  7. Swieboda P, Filip R, Prystupa A, Drozd M. Assessment of pain: types, mechanism and treatment. Ann Agric Environ Med. 2013;1:2-7.

  8. Chen G, Zhang YQ, Qadri TJ, Serhan CN, Ji RR. Microglia in pain: detrimental and protective roles in pathogenesis and resolution of pain. Neuron. 2018;100:1292-1311.

  9. Sekülic S, Gebauer-Bukurov K, Cvijanovic M, et al. Appearance of fetal pain could be associated with maturation of the mesodiencephalic structures. J Pain Res. 2016;9:1031-1038.

  10. Derbyshire S, Bockmann JC. Reconsidering fetal pain. J Med Ethics. 2020;46:3-6.

  11. Pierucci R. Fetal pain: the science behind why it is the medical standard of care. Linacre Q. 2020;87:311-316.

  12. Ellison D.L. Physiology of pain. Crit Care Nurs Clin North Am. 2017;26:397-406.

  13. Bellieni CV. Analgesia for fetal pain during prenatal surgery: 10 years of progress. Pediatr Res. 2021;89:1612-1618.

  14. Grupo de Trabajo de Dolor en Neonatología, Comité de Estudios Feto-Neonatales (CEFEN). Manejo del dolor en Neonatología. Arch Argent Pediatr. 2019;117:S180-S194.

  15. Perry M, Tan Z, Chen J, Weidig T, Xu W, and Cong XS. Neonatal pain: perceptions and current practice. Crit Care Nurs Clin North Am. 2018;30:549-561.

  16. Allegaert K and Anker JN. Neonatal pain management: still in search of the Holy Grail. Int J of Clin Pharmacol Ther. 2017;54:514-523.

  17. AAP committee on fetus and newborn and section on anesthesiology and pain medicine. Prevention and management of procedural pain in the neonate: an update. Pediatrics. 2016;137:e20154271.

  18. Lowery CL, Hardman MP, Manning N, Clancy B, Hall RW, and Anand KJS. Neurodevelopmental changes of fetal pain. Semin Perinatol. 2007;31:275-282.

  19. González C. Pharmacology In The Pediatric Patient. Rev Med Clin Condes. 2016;27:652-659.

  20. Allegaert K, van de Velde M, van den Anker J. Neonatal clinical pharmacology. Paediatr Anaesth. 2014;24:30-38. doi: 10.1111/pan.12176.

  21. Batchelor HK, Marriott JF. Paediatric pharmacokinetics: key considerations. Br J Clin Pharmacology. 2015;79:395-404.

  22. Martin LD. Principios básicos de la anestesia neonatal. Rev Colomb Anestesiol. 2017;45:54-61.

  23. Lu H, Rosenbaum S. Developmental pharmacokinetics in pediatric populations. J Pediatr Pharmacol Ther. 2014;19:262-276.

  24. Chau C, Ranger M, Bichin M, et al. Hippocampus, amygdala, and thalamus volumes in very preterm children at 8 years: neonatal pain and genetic variation. Front Behav Neurosci. 2019;13:1-14.

  25. Doesburga DS, Chaud CM, Cheungd TPL, et al. Neonatal pain-related stress, functional cortical activity and visual-perceptual abilities in school-age children born at extremely low gestational age. Pain. 2013;154:1946-1952.

  26. Walker SM. Long-term effects of neonatal pain. Semin Fetal Neonatal Med. 2019;24:101005.




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