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2023, Number 4

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Rev Fac Med UNAM 2023; 66 (4)

The Role of Heat Shock Proteins in Viral Infections

Olvera-Sánchez S, Martínez F

Language: Spanish
References: 84
Page: 8-19
PDF size: 466.52 Kb.


ABSTRACT

Heat shock proteins (HSP) were first described as a cell response to heat stress. However, over time, it has become clear they have multiple functions inside and outside cells, and that they actively participate in different physiological and pathological processes. They perform functions related to their cellular location or physiological moment, which is why they have been called multi-use proteins or “moonlighting proteins”. Furthermore, HSP activity is associated with different structural conformations, from peptides derived from them or as dimers or multimers, to mention a few. This article describes these functions and their relationship with the immune system, and their relationship with viral infection, particularly with inflammatory processes.


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