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2021, Number 4

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Rev Cubana Hematol Inmunol Hemoter 2021; 37 (4)

CD5 positive Diffuse large B cell lymphoma with prostate involvement: An unusual recurrence

Castro UDA, Tarazona LDS, Mendoza CR, Beltrán GBE

Language: Spanish
References: 39
Page: 1-12
PDF size: 448.16 Kb.


ABSTRACT

Introduction: CD5 positive Large B-cell Lymphoma (CD5 + DLBCL) constitutes a rare and aggressive pathology with poor response to chemoimmunotherapy.
Objective: To describe a case with a diagnosis of CD5 + DLBCL with an unusual recurrence in the prostate.
Clinical case: A 61-year-old male presented abdominal pain and B symptoms. Imaging studies showed mediastinal and retroperitoneal lymphadenopathy. The pathology informed a CD5+ DLBCL diagnosis, receiving first-line R-CHOP treatment and achieving complete remission, with prostatic early relapse confirmed by immunohistochemistry. Therefore, he received R-ICE as rescue treatment with poor response and performance status decline.
Conclusions: CD5 + LDCGB represents a rare and aggressive disease, being the prostate relapse a very unusual event, in which the exhaustive clinical and pathological workup is essential for an accurate diagnosis. To date, the response to standard or higher-intensity therapies is disappointing, so more studies are needed in the future.


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