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2022, Number 4

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Rev Hematol Mex 2022; 23 (4)

Comparison among different inflammatory indices as predictors of cell morphology in childhood leukemia

Villalobos-Espinosa DL, Sánchez-Valdivieso EA

Language: Spanish
References: 10
Page: 237-245
PDF size: 319.03 Kb.


ABSTRACT

Objective: To determine the usefulness of the neutrophil-lymphocyte, platelet-lymphocyte, platelet-neutrophil, monocyte-neutrophil, lymphocyte-monocyte and mean platelet volume indices as a diagnostic tool in childhood acute lymphoblastic leukemia.
Materials and Methods: Observational, analytical cross-sectional, retrospective study was done including records of pediatric patients with acute lymphoblastic leukemia (ALL), dividing them into two groups: carriers of ALL type L1 and ALL with L2/L3 morphology. Blood count data were collected and with them the different indices were calculated and studied using ROC curves to assess their usefulness as a diagnostic tool.
Results: Of a total of 102 patients, 80 corresponded to ALL L1 and 22 to ALL L2/ L3; 45.1% were women. Using ROC curves, an area under the curve for lymphocytemonocyte index of 0.572 was determined and a sensitivity of 63.8% and a specificity of 63.6% were obtained for the presumptive diagnosis of ALL L1.
Conclusions: The lymphocyte-monocyte index turned out to be the best for presumptive diagnosis of childhood acute lymphoblastic leukemia type L1.


REFERENCES

  1. El cáncer infantil [Internet]. Who.int. 2018 [cited 10 August 2019]. Available from: https://www.who.int/es/newsroom/fact-sheets/detail/cancer-in children.

  2. Asociación Mexicana de Ayuda a Niños con Cáncer. Cáncerinfantil [Internet]. Amanc.org. 2018 [cited 10 August 2019].Available from: https://www.amanc.org/cancer-infantil/.

  3. Padhi S, Sarangi R, Mohanty P, Das R, Chakravarty S,Mohanty R, et al. Cytogenetic profile of pediatric acutelymphoblastic leukemia (ALL): analysis of 31 cases withreview of literature. Caryologia 2011; 64 (1): 33-41. https://doi.org/10.1080/00087114.2011.10589762.

  4. Beltrán B, Ramos Muñoz W, De La Cruz Vargas J. Índicelinfocito/monocito como factor pronóstico en Linfomade Células Grandes Difuso, Hospital Edgardo RebagliatiMartins 2010-2017. Revista de la Facultad de MedicinaHumana 2019; 19 (2).

  5. Luo H, He L, Zhang G, Yu J, Chen Y, Yin H, et al. Normal referenceintervals of neutrophil-to-lymphocyte ratio, plateletto-lymphocyte ratio, lymphocyte-to-monocyte ratio, andsystemic immune inflammation index in healthy adults: Alarge multi-center study from Western China. Clinical Laboratory2019; 65 (3). doi: 10.7754/Clin.Lab.2018.180715.

  6. Lee J, Kim N, Na S, Youn Y, Shin C. Reference values ofneutrophil-lymphocyte ratio, lymphocyte-monocyte ratio,platelet-lymphocyte ratio, and mean platelet volume inhealthy adults in South Korea. Medicine 2018; 97 (26):e11138. doi: 10.1097/MD.0000000000011138.

  7. Lee S, Luque-Fernandez M. Prognostic value of lymphocyte-to-monocyte ratio and neutrophil-to-lymphocyteratio in follicular lymphoma: a retrospective cohort study.BMJ Open. 2017;7(11):e017904. doi: 10.1136/bmjopen-2017-017904.

  8. Lee S, Ng T, Spika D. Prognostic value of lymphocytemonocyteratio at diagnosis in Hodgkin lymphoma: ameta-analysis. BMC Cancer 2019; 19 (1). doi: 10.1186/s12885-019-5552-1.

  9. Acosta MB, Grimaldo GF, De la Torre LA, Gómez PG, HernándezRH. Valor pronóstico del índice linfocitos/monocitosabsolutos en linfoma de Hodgkin clásico. Experiencia enel Instituto Nacional de Cancerología. Rev Hematol 2014;15: 175-176.

  10. Tian Y, Zhang Y, Zhu W, Chen X, Zhou H, Chen W. Peripheralblood lymphocyte-to-monocyte ratio as a usefulprognostic factor in newly diagnosed multiple myeloma.BioMed Research Internat. 2018; 2018: 1-8. doi:10.1155/2018/9434637.




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