2023, Number 2
Immunological basis that supports the treatment of Multi-System Inflammatory Syndrome in Children (MIS-C /PIMS)
Language: Spanish
References: 29
Page: 146-160
PDF size: 272.03 Kb.
ABSTRACT
Pediatric inflammatory multisystemic syndrome temporarily associated with COVID- 19 (MIS-C/PIMS) is a new post-infectious condition, secondary to SARS-CoV2 infection. It has been characterized by an inflammatory response with multisystem involvement, involving several mechanisms of immune damage such as an exaggerated increase in cytokines and epithelial damage. Immunomodulatory treatment is aimed at controlling the manifestations of hyperinflammation, to stabilize and prevent long-term sequelae.REFERENCES
Ramanathan K, Antognini D, Combes A, Paden M, ZakharyB, Ogino M, et al. Since January 2020 Elsevier has created aCOVID-19 resource centre with free information in Englishand Mandarin on the novel coronavirus COVID- research thatis available on the COVID-19 resource centre - including thisfor unrestricted research re-use a. 2020;(January):19-21.
Henderson LA, Canna SW, Friedman KG, Gorelik M, LapidusSK, Bassiri H, et al. American College of RheumatologyClinical Guidance for Multisystem Inflammatory Syndromein Children Associated With SARS–CoV-2 and Hyperinflammationin Pediatric COVID-19: Version 1. Vol. 72, Arthritisand Rheumatology. 2020. 1791-1805 p.
Shubhi Kaushik, MBBS1,*, Scott I. Aydin, MD1, 2,*,Kim R. Derespina, MD3, PrernaB.Bansal, MD2, ShannaKowalsky D, Rebecca Trachtman, MD5, JenniferK.Gillen,MD1, Michelle M. Perez, MD3, Sara H. Soshnick, DO,MS3, Edward E. Conway, Jr., MD6, Asher Bercow, MD6,HowardS.Seiden, MD2, Robert H.Pass, MD2, Henry M.Ushay, MD, PhD3, George Ofori-Amanfo, MD1, 2, andShivanand 7, Objective. Multisystem InflammatorySyndrome in Children Associated with Severe AcuteRespiratory Syndrome Coronavirus 2 Infection (MIS-C /PIMS): A Multi-institutional Study from New York City. JPediatr. 2020;224:24-9.