2023, Number 3
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Acta Med 2023; 21 (3)
Takayasu arteritis
Domínguez CLG, Arellano AJG, Arellano GG
Language: Spanish
References: 26
Page: 262-267
PDF size: 197.86 Kb.
ABSTRACT
Takayasu arteritis is an inflammatory disease of medium and large-caliber arteries, with a predilection for the aorta and its branches. The lesions produced by the inflammatory process can be stenotic, occlusive, or aneurysmal. Vascular changes lead to the main complications. Although the management of Takayasu arteritis is improving, the diagnosis is usually delayed. Although the broader use of non-invasive imaging has improved, clinicians are still responsible for considering the earlier diagnosis. A review of the current situation is carried out. Understanding of the pathogenesis of the disease remains poor. However, recent genetic data and identifying pathogenic cytokines may facilitate the search for biomarkers distinguishing between active and inactive disease and inflammatory and non-inflammatory arterial remodeling. Imaging is critical for diagnosis, evaluation, and disease progression. Reliance on Steroid therapy remains too high. However, the impact of combination immunosuppressive therapy is now recognized, biological therapies are becoming more widely available, and new agents show promise, trying to modify morbidity and mortality.
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