2022, Number 2
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Arch Med 2022; 22 (2)
Characterization of patients with thrombocytopenia in a third level of complexity institution in Medellin, Colombia
Martínez-Sanchez LM, Hernández-Martínez A, Roldan-Tabares MD, Herrera-Almanza L, Villegas-Alzate JD, Calle-Estrada MC, Aristizábal-Hernández JJ, Vergara-Yanez D
Language: Spanish
References: 20
Page: 319-325
PDF size: 201.97 Kb.
ABSTRACT
Objective: characterize patients with thrombocytopenia in a third level-ofcomplexity
institution in Medellín, Colombia.
Materials and methods: a retrospective
descriptive study was carried out, which included all patients with
thrombocytopenia-related diagnosis treated in a level-of-complexity institution in
the city of Medellin, during the January 2016 to December 2017-time period. A
non-probabilistic sampling of consecutive cases was done.
Results: 25 patients
with thrombocytopenia were included. 80% of them (20) corresponded to children
under 1 year of age and 20% (5) to people over 18 years of age, 52% (13) were
male. Median in-hospital stay for adults was 10 days with a P25 of 5 and P75 of
39, for those aged ‹1 year, it was 32 (P25: 15 and P75: 53.25). 80% (20) of the
patients were classified with unspecified thrombocytopenia, the remaining 20% (5)
with secondary thrombocytopenia. The platelet counts in adults had a median of
95.000 cells/mm3 (P25: 67.000 and P75: 122.00) and in ‹1 year the median was
79.000 cells/mm3 (P25: 53.750 and P75: 109.750).
Conclusions: thrombocyto
penia was more common in children under 1 year and in the male sex, requiring
longer hospital stays. Thrombocytopenia for both groups was classified as mild
and according to its diagnosis as unspecified.
REFERENCES
Lee EJ, Lee AI. Thrombocytopenia. Prim Care. 2016;43(4):543-557. DOI: 10.1016/j.pop.2016.07.008
Fountain EM, Arepally GM. Etiology and complications of thrombocytopenia in hospitalized medical patients. JThromb Thrombolysis. 2017;43(4):429-436. DOI: 10.1007/s11239-016-1467-8.
Nagalla S, Sarode R. Recent advances in understanding and management of acquired thrombocytopenia.F1000Res. 2018; 7:68-77. doi: 10.12688/f1000research.12309.1
Gauer RL, Braun MM. Thrombocytopenia. Am Fam Physician. 2012;85(6):612-622. PMID: 22534274
Akca S, Haji-Michael P, de Mendonça A, Suter P, Levi M, Vincent JL. Time course of platelet counts in criticallyill patients. Crit Care Med. 2002;30(4):753-756. DOI:10.1097/00003246-200204000-00005
Crowther MA, Cook DJ, Meade MO, Griffith LE, Guyatt GH, Arnold DM, et al. Thrombocytopenia in medicalsurgicalcritically ill patients: prevalence, incidence, and risk factors. J Crit Care. 2005;20(4):348-353.DOI: 10.1016/j.jcrc.2005.09.008
Thachil J, Warkentin TE. How do we approach thrombocytopenia in critically ill patients? Br J Haematol. 2017;177(1):27-38. doi: 10.1111/bjh.14482
Greenberg EM. Thrombocytopenia: A Destruction of Platelets. J Infus Nurs. 2017;40(1):41-50.DOI:10.1097/NAN.0000000000000204
Nandyal S, Shashikala P, Sahgal V. Study of thrombocytopenia in neonatal intensive care unit. IJPO. 2016;3(1);55-59. DOI: 10.5958/2394-6792.2016.00012.0
Khalessi N, Khosravi N, Sanii S, Zareh Mehrjerdi F. The Prevalence and Risk Factors for Neonatal Thrombocytopeniaamong Newborns Admitted to Intensive Care Unit of Aliasghar Children’s Hospital. IJBC. 2013;2: 41-45
Jeremiah Z, Oburu J. Pattern and prevalence of neonatal thrombocytopenia in Port Harcourt, Nigeria. Pathologyand Laboratory Medicine International. 2010; 2:27-31
Beiner ME, Simchen MJ, Sivan E, Chetrit A, Kuint J, Schiff E. Risk Factors for Neonatal Thrombocytopenia inPreterm Infants. Am. J. Perinatol. 2003:20(1); 49-54.
Grace RF, Shimano KA, Bhat R, Neunert C, Bussel JB, Klaassen RJ, et al. Second-line treatments in childrenwith immune thrombocytopenia: Effect on platelet count and patient-centered outcomes. Am J Hematol. 2019;94(7):741-750. doi: 10.1002/ajh.25479
Mahévas M, Moulis G, Andres E, Riviere E, Garzaro M, Crickx E, et al. Clinical characteristics, management andoutcome of COVID-19-associated immune thrombocytopenia: a French multicentre series. Br J Haematol. 2020;190(4): e224-e229. doi: 10.1111/bjh.17024
Bolat F, Kılıç SÇ, Oflaz MB, Gülhan E, Kaya A, Güven AS, et al. The prevalence and outcomes of thrombocytopeniain a neonatal intensive care unit: a three-year report. Pediatr Hematol Oncol. 2012;29(8):710-720.DOI:10.3109/08880018.2012.725454
Vaughan JL, Fourie J, Naidoo S, Subramony N, Wiggill T, Alli N. Prevalence and causes of thrombocytopenia inan academic state-sector laboratory in Soweto, Johannesburg, South Africa. S Afr Med J. 2015;105(3):215-219.DOI:10.7196/samj.8791
Shalansky SJ, Verma AK, Levine M, Spinelli JJ, Dodek PM. Risk markers for thrombocytopenia in critically illpatients: a prospective analysis. Pharmacotherapy. 2002;22(7):803-813. DOI:10.1592/phco.22.11.803.33634
Crespo EM, Oliveira GB, Honeycutt EF, Backer RC, Berger PB, Moliterno DJ et al. Evaluation and managementof thrombocytopenia and suspected heparin-induced thrombocytopenia in hospitalized patients: The ComplicationsAfter Thrombocytopenia Caused by Heparin (CATCH) registry. Am Heart J. 2009;157(4):651-657.DOI: 10.1016/j.ahj.2009.01.005
Chao CJ, Shanbhag A, Chiang CC, Girardo ME, Seri AR, Khalid MU, et al. Baseline thrombocytopenia in acutecoronary syndrome: The lower, the worse. International Journal of Cardiology. 2021; 332: 1-7.doi: 10.1016/j.ijcard.2021.03.059.
Venkata C, Kashyap R, Farmer JC, Afessa B. Thrombocytopenia in adult patients with sepsis: incidence, riskfactors, and its association with clinical outcome. J Intensive Care. 2013;1(1):9. DOI:10.1186/2052-0492-1-9.