Guzmán OTC, Escandón PS, Shuchleib CM, Pliego LM, Galván LF, Llaca MB, de la Barreda F

Language: Spanish
References: 21
Page: 67-76
PDF size: 262.89 Kb.

ABSTRACT

Drug reaction with eosinophilia and systemic symptoms syndrome (DRESS) is a severe cutaneous drug reaction characterized by a skin rash, lymphadenopathy, hematologic abnormalities, and multi-organ involvement. Allopurinol, anticonvulsants, sulfonamides, and antibiotics are the most frequently implicated drugs. The onset of clinical manifestations is usually two to three weeks from initial drug exposure. Diagnosis is based on a combination of clinical and laboratory findings. Hematologic abnormalities include eosinophilia, neutrophilia, monocytosis, and atypical lymphocytes; lymphadenopathy has been identified. The most affected organ is the liver. Treatment varies depending on severity. Most patients recover completely with discontinuation of the offending drug. Systemic corticosteroids are the treatment of choice. Support measures should be associated to control symptoms such as itching, inflammation control with topical and/or systemic medications.

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