González GMF, Cortés PEC

Language: Spanish
References: 14
Page: 40-44
PDF size: 169.17 Kb.

ABSTRACT

Isotretinoin is considered the only acne drug capable of changing the natural course of the disease. However, outbreaks, or flare up, of acneiform lesions have been described after drug administration; patients can present a paradoxical exacerbation of acne, particularly of the inflammatory component. The risk factors identified are: initiation of treatment with high doses of isotretinoin, the presence of macrocomedones or multiple closed microcomedones, and types of acne with an underlying inflammatory component. There are preventive and alternative therapies for the treatment of acne flare ups, the latter used when remission of the disease is not achieved with isotretinoin. We present two cases with paradoxical acne outbreak associated to isotretinoin and, its consequent remission with antiinflammatory therapy.

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