2023, Number 2
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Med Int Mex 2023; 39 (2)
Correlation between ventilation perfusion PaO2/FiO2 ratio and SpO2/FiO2 ratio in hospitalized adult COVID-19 patients
Mendoza-Morimoto II, López-López RM
Language: Spanish
References: 33
Page: 227-234
PDF size: 342.42 Kb.
ABSTRACT
Objective: To determine the correlation between the ventilation perfusion PaO
2/FiO
2
ratio and the SpO2/FiO
2 ratio in hospitalized COVID-19 patients.
Materials and Methods: Retrospective, cross-sectional, analytical, single-center
epidemiological study. It included patients who were admitted with a COVID-19
diagnosis to the High Specialty Unit no. 2 from June 1
st to August 31
st, 2020. Oxygen
saturation and FiO
2 contribution were reviewed in the electronic file, as well as an
arterial blood gas report.
Results: One hundred eighty-six patients were evaluated, of which 52.2% were men;
mean age was of 59.17 years. It was found that 14.5% were health personnel. An average
hospital stay of 10.45 days was observed; 32.3% of the population studied died.
A positive correlation was observed between the SpO
2/FiO
2 and PaO
2/FiO
2 indices (r
= 0.798). After carrying out the linear regression, we obtained an r
2 of 0.634, so we
can predict the oxygenation value by 63.4% through non-invasive measurements.
Conclusions: This study allowed to validate the positive correlation between the
non-invasive respiratory SpO
2/FiO
2 ratio and the invasive respiratory PaO
2/FiO
2 ratio
for the classification of severity in acute respiratory failure syndrome in infection by
SARS-CoV-2 and thus offer an alternative for the hospital care areas that do not have
a gasometer available.
REFERENCES
Rodríguez-Roisin R GN. Fisiología humana. Tresguerres JA,et al. Madrid: Mc-GrawHill; 2005: 618-633.
Cardinal-Fernández P, Bajwa EK, Dominguez-Calvo A, MenéndezJM, Papazian LTB. The presence of diffuse alveolardamage on open lung biopsy is associated with mortalityin patients with acute respiratory distress syndrome: asystematic review and meta-analysis. Chest 2016; 149 (5):1155-1164. doi: 10.1016/j.chest.2016.02.635.
Salvatici M, Barbieri B, Cioffi SMG, Morenghi E, Leone FP,Maura F, et al. Association between cardiac troponin I andmortality in patients with COVID-19. Biomarkers 2020; 25(8): 634-40. doi: 10.1080/1354750X.2020.1831609.
Dhont S, Derom E, Van-Braeckel E, Depuydt P LB. The pathophysiologyof happy hypoxemia in COVID-19. Respir Res 2020;21 (1): 1-9. https://doi.org/10.1186/s12931-020-01462-5.
Rincón-Salas JJ. Correlación de los índices PaO2/FiO2 ySpO2/FiO2 en el postoperatorio de la cirugía cardiaca enuna Unidad de Terapia Posquirúrgica Cardiovascular. RevAsoc Mex Med Crit y Ter Int 2013; 27 (2): 71-6.
Trillo-Alvarez C, Cartin-Ceba R, Kor DJ, Kojicic M, KashyapR TS. Acute lung injury prediction score: derivation andvalidation in a population-based sample. Eur Respir J 2011;37 (3): 604-9. doi: 10.1183/09031936.00036810.
Bernard GR, Artigas A, Brigham KL, Carlet J, et al. TheAmerican European Consensus Conference on ARDS:definitions, mechanisms, relevant outcomes, and clinicaltrial coordination. Am J Respir Crit Care Med 1994; 149:
818-824. doi: 10.1164/ajrccm.149.3.7509706.8. Cortés-Telles A, Gochicoa-Rangel LG, Pérez-Padilla R,Torre-Bouscoulet L. Gasometría arterial ambulatoria. Recomendacionesy procedimiento. NCT Neumol y CirugíaTórax 2017; 76 (1): 44-50.
Force ADT, Ranieri VM, Rubenfel GD, Thompson BT, FergusonND CE. Acute respiratory distress syndrome. JAMA2012; 307 (23): 2526-33. doi: 10.1001/jama.2012.5669.
Carrillo-Esper R, Sánchez-Zúñiga MJ, Medveczky-Ordóñez N,Carrillo-Córdova DM. Evolución de la definición del síndromede insuficiencia respiratoria aguda. Med Int Méx. 2018; 34(4): 594-600. doi: https://10.24245/mim.v34i4.2092
Bellani G, Laffey JG, Pham T, Fan E, et al and on behalfof the LSI and the ETG. The LUNG SAFE Study: a presentationof the prevalence of ARDS according to the BerlinDefinition. Crit Care Med 2016; 20 (1): 268. doi: 10.1186/s13054-016-1443-x.
Riviello ED, Kiviri W TT. Hospital incidence and outcomesof the acute respiratory distress syndrome using the Kigalimodification of the Berlin definition. Am J Respir Crit CareMed 2016; 193: 52-59. doi: 10.1164/rccm.201503-0584OC.
Ludvigsson JF. Systematic review of COVID‐19 in childrenshows milder cases and a better prognosis than adults. ActaPaediatr 2020; 109 (6): 1088-95. doi: 10.1111/apa.15270.
Ameghuino Bautista J, Morales Corbacho Jorge ASM.Correlación entre SO2/FiO2 y PaO2/FiO2 en pacientes coninsuficiencia respiratoria en ventilación mecánica. Rev CubaInvest Bioméd 2018; 37 (3): 1-9.
Tobin MJ. Basing respiratory management of COVID-19 onphysiological principles. Am J Respir Crit Care Med 2020;201 (11): 1319-20. doi: 10.1164/rccm.202004-1076ED.
Severinghaus JW. Simple, accurate equations for humanblood O2 dissociation computations. J Appl Physiol RespirEnviron Exerc Physiol 1979; 46 (3): 599-602. doi: 10.1152/jappl.1979.46.3.599.
Rice TW, Wheeler AP, Bernard GR, Hayden DL, et al. Comparisonof the SpO2/FIO2 ratio and the PaO2/FIO2 ratio inpatients with acute lung injury or ARDS. Chest 2007; 132(2): 410-7. doi: 10.1378/chest.07-0617.
Spada C, Gandhi R, Patel SR, Nuccio P, Weinhouse GL LP.Oxygen saturation/fraction of inspired oxygen ratio is asimple predictor of noninvasive positive pressure ventilationfailure in critically ill patients. J Crit Care 2011; 26 (5):510-6. doi: 10.1016/j.jcrc.2010.08.015.
Brown SM, Grissom CK, Moss M, Rice TW, Schoenfeld DHPNPNC. Nonlinear imputation of Pao2/Fio2 from Spo2/Fio2 among patients with acute respiratory distresssyndrome. Chest 2016; 150 (2): 307-13. doi: 10.1016/j.chest.2016.01.003.
Kumar A, Aggarwal R, Khanna P, Kumar R, et al. Correlationof the SpO2/FiO2 (S/F) ratio and the PaO2/FiO2 (P/F) ratioin patients with COVID-19 pneumonia. Med Intensiva 2021.doi: 10.1016/j.medin.2021.10.005.
Michard F, Shelley K, L'Her E. COVID-19: Pulse oximetersin the spotlight. J Clin Monit Comput 2021; 35 (1):11-14. 2021 Feb;35(1):11-14. doi: 10.1007/s10877-020-00550-7.
Secretaría de Salud, México, CENAPRECE, Institución Nacionalde Salud Pública, IMSS, INEGI, CONAPO ROP de lasalud. Boletín E. Boletín estadístico. 2020; 1-27.
Abuabara-Franco E, Bohórquez-Rivero J, Restom-ArrietaJ, Uparella-Gulfo I, et al. Infección por SARS-CoV-2 yenfermedad COVID-19: revisión literaria. Rev Salud Uninorte2020; 36 (1): 196-230. https://doi.org/10.14482/sun.36.1.616.211.
Petrova D, Salamanca-Fernández E, Rodríguez-BarrancoM, Navarro-Pérez P, Jiménez-Moleón JJ, Sánchez MJ. Laobesidad como factor de riesgo en personas con COVID-19:posibles mecanismos e implicaciones. Aten Primaria 2020;52 (7): 496-500. doi: 10.1016/j.aprim.2020.05.003.
Estudio Ene-COVID: cuarta ronda. 2020; 2-7.
Nienhaus A, Hod R. COVID-19 among health workers inGermany and Malaysia. Int J Environ Res Public Health2020; 17 (13): 1-10. doi: 10.3390/ijerph17134881.
Organización Panamericana de la Salud/OrganizaciónMundial de la Salud. Actualización EpidemiológicaEnfermedad por coronavirus. 9 de febrero 2021. InstitutionalRepos Inf Shar [Internet]. 2021;2019(2005):1–21.Available from: https://iris.paho.org/bitstream/handle/10665.2/53378/EpiUpdate9February2021_spa.pdf?sequence=2&isAllowed=y.
Santos CS, Morales CM, Álvarez ED, Castro CÁ, RoblesAL, Sandoval TP. Determinants of COVID-19 diseaseseverity in patients with underlying rheumatic disease.Clin Rheumatol 2020; 39 (9) :2789-2796. doi: 10.1007/s10067-020-05301-2.
Rees EM, Nightingale ES, Jafari Y, Waterlow NR, Clifford S,Carl CA, et al. COVID-19 length of hospital stay: A systematicreview and data synthesis. BMC Med 2020; 18 (1). https://doi.org/10.1186/s12916-020-01726-3.
Escobar G, Matta J, Taype-Huamaní W, Ayala R, Amado J.Características clínicoepidemiológicas de pacientes fallecidospor COVID-19 en un hospital nacional de Lima, Perú.Rev la Fac Med Humana 2020; 20 (2): 180-5.
Ceylan Z. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in Englishand Mandarin on the novel coronavirus COVID- 19 . TheCOVID-19 resource centre is hosted on Elsevier Connect,the company’s public news and information. 2020; January.
Khemani RG, Patel NR, Bart RD NC. Comparison of thepulse oximetric saturation/fraction of inspired oxygen ratioand the PaO2/fraction of inspired oxygen ratio in children.Chest 2009; 135 (3): 662-8. doi: 10.1378/chest.08-2239.
Schmidt MF, Gernand J, Kakarala R. The use of the pulseoximetric saturation to fraction of inspired oxygen ratio inan automated acute respiratory distress syndrome screeningtool. J Crit Care 2015; 30 (3): 486-90. doi: 10.1016/j.jcrc.2015.02.007.