2021, Number 3
Clear cell type renal carcinoma with sarcomatoid differentiation
Language: Spanish
References: 12
Page: 1-8
PDF size: 555.46 Kb.
ABSTRACT
Introduction: clear cell type renal carcinoma with sarcomatoid differentiation is a rare tumor.Objective: to report the diagnosis of a clear cell type renal carcinoma with sarcomatoid differentiation.
Case report: a 59-year-old, heavy smoker male patient, attending to the doctor’s office presenting lumbar pain and hematuria. The imaging studies showed a tumor lesion in the right kidney. Surgical treatment was indicated and the histopathological study reported a clear cell type renal carcinoma with sarcomatoid differentiation. The patient underwent chemotherapy and at present he maintains oncological follow-up.
Conclusions: clear cell type renal carcinoma with sarcomatoid differentiation is rare. The treatment of election is surgery and pathology report confirms the true diagnosis.
REFERENCES
Queipo FJ, Panizo A, Sola JJ, Beorlegui C, Velis JM, Dolezal P, et al. Carcinomas renales con rasgos sarcomatoides y rabdoides: estudio clínico-patológico de 74 casos. Anales Sis San Navarra [Internet]. 2018 [citado 21/11/2020]; 41(2): 191-199. Disponible en: Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1137-66272018000200191
Cortés-Vázquez YD, Cortés-Vázquez AR, Priego-Niño A, Fernández-Vivar E, Silva-Bravo F, Gutiérrez-Quiróz C. Carcinoma renal de células claras con patrón sarcomatoide asociado a metástasis gingival. Reporte de caso y revisión de la literatura. Cir Cir [Internet]. 2020 [citado 21/11/2020]; 88(s1): 54-58. Disponible en: Disponible en: https://www.cirugiaycirujanos.com/files/circir_20_88_supl_1_054-058.pdf
Díaz Goizueta FJ. Factores que influyen en la supervivencia a largo plazo en el cáncer renal de células claras después de la nefrectomía radical [tesis doctoral]. Salamanca: Universidad de salamanca; 2018 [citado 21/11/2020]. Disponible en: Disponible en: https://gredos.usal.es/bitstream/handle/10366/140314/DC_DiazGoizuetaFJ_SupervivenciaC%C3%A1ncerRenalC%C3%A9lulasClaras.pdf?sequence=1&isAllowed=y
Miranda Utrera NR. Análisis molecular del carcinoma renal de células claras. Identificación de un perfil de micrornas como factor pronóstico en pacientes en estadio I-II [tesis doctoral]. Madrid: Universidad Complutense de Madrid; 2017 [citado 21/11/2020]. Disponible en: Disponible en: https://eprints.ucm.es/41377/
Malouf GG, Flippot R, Dong Y, Dinatale RG, Chen YB, Su X, et al. Molecular characterization of sarcomatoid clear cell renal cell carcinoma unveils new candidate oncogenic drivers. Rev Scientific Reports [Internet]. 2020 [citado 21/11/2020]; 10(701): [aprox. 10 p.]. Disponible en: Disponible en: https://www.nature.com/articles/s41598-020-57534-5
Yu W, Wang X, Wang Y, Jiang Y, Zhang W, Shi H, et al. A novel highly frequent single-nucleotide polymorphism site of cadherin 23 in clear cell renal cell carcinoma with sarcomatoid differentiation based on whole exome sequencing. Rev Oncology Reports [Internet]. 2020 [citado 21/11/2020]; 44(2): 735-746. Disponible en: Disponible en: https://pubmed.ncbi.nlm.nih.gov/32468012/
Boustany J, Abdessater M, El Hachem C, El Khoury Z, El Khoury W, El Khoury R. Recurrent metastatic clear cell renal carcinoma with sarcomatoid dedifferentiation treated with surgery and Cabozantinib. Rev Oncotarget [Internet]. 2020 [citado 21/11/2020]; 11(20): 1922-1928. Disponible en: Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244017/
Bi M, Zhao S, Said JW, Merino MJ, Adeniran AJ, Xie Z, et al. Genomic characterization of sarcomatoid transformation in clear cell renal cell carcinoma. Rev PNAS [Internet]. 2016 [citado 21/11/2020]; 113(8): 2170-2175. Disponible en: Disponible en: https://www.pnas.org/content/pnas/113/8/2170.full.pdf
Massari F, Di-Nunno V, Gatto L, Santoni M, Schiavina R, Cosmai L, et al. Should Carmena really change our attitude towards cytoreductive nephrectomy in metastatic renal cell carcinoma? A systematic review and meta-analysis evaluating cytoreductive nephrectomy in the era of targeted therapy. Targeted Oncology [Internet]. 2018 [citado 21/11/2020]; 13(6): 705-714. Disponible en: Disponible en: https://pubmed.ncbi.nlm.nih.gov/30324488/
Alevizakos M, Gaitanidis A, Nasioudis D, Msaouel P, Appleman LJ. Sarcomatoid renal cell carcinoma: population-based study of 879 patients. Rev Clinical Genitourinary Cancer [Internet]. 2018 [citado 21/11/2020]; 17(3): 447-453. Disponible en: Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S155876731930014X
El Mouallem N, SC Smith, AK Paul. Sarcomatoid renal cell carcinoma: Biology and treatment advances. Rev Urologic Oncology: Seminars and Original Investigations [Internet]. 2019 [citado 21/11/2020]; 36(6): 265-271. Disponible en: Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S1078143917306257