2023, Number 2
<< Back Next >>
Med Crit 2023; 37 (2)
SARS-CoV-2 patient with heparin-induced thrombocytopenia and white thrombi syndrome
Giraldo SJM
Language: Spanish
References: 26
Page: 141-145
PDF size: 193.88 Kb.
ABSTRACT
Heparin-induced thrombocytopenia is an uncommon clinical entity, however the wide and massive use of anticoagulants in times of pandemic by COVID-19 reveals an evident reality and we can not escape. we present the case of a male patient in sixth decade of life with SARS-CoV-2 who after the administration of heparin in the clinical setting of thromboembolic lung disease development platelet consumption associated with the presence of antibodies anti platelet activating factor 4.
REFERENCES
Ji D, Zhang D, Xu J, Chen Z, Yang T, Zhao P, et al. Prediction for progression risk in patients with COVID-19 pneumonia: the CALL score. Clin Infect Dis. 2020;71(6):1393-1399. doi: 10.1093/cid/ciaa414.
Chandel A, Patolia S, Brown AW, Collins AC, Sahjwani D, Khangoora V, et al. High-flow nasal cannula therapy in COVID-19: using the ROX index to predict success. Respir Care. 2021;66(6):909-919. doi: 10.4187/respcare.08631.
Brown SD, Clark C, Gutierrez G. Pulmonary lactate release in patients with sepsis and the adult respiratory distress syndrome. J Crit Care. 1996;11(1):2-8.
Routsi C, Bardouniotou H, Delivoria-Ioannidou V, Kazi D, Roussos C, Zakynthinos S. Pulmonary lactate release in patients with acute lung injury is not attributable to lung tissue hypoxia. Crit Care Med. 1999;27(11):2469-2473.
Rosenblatt WH, Abrons RO, Sukhupragarn W. Airway management. In: Barash PG, Cullen BF, Stoelting RK, et al. Clinical anesthesia. 8th ed. Philadelphia, PA: Wolters Kluwer; 2017. pp. 1901-2004.
Finucane B, Tsui BC, Santora A. The difficult airway. In: Principles of airway management. 4th ed. New York: Springer; 2011. pp. 361-414.
Giraldo Sánchez JM, Badillo E, Pacheco J, Beltrán E, Barranco E, Leonardo Rojas RG. Insuflación de gas traqueal como estrategia de rescate en hipoxemia refractaria por edema pulmonar multifactorial en paciente con hemorragia subaracnoidea. Acta Colomb Cuid Intensivo. 2015;15:220-226.
Giraldo JM, Vargas F, Cantillo GA. Ventilación mecánica protectora más insuflación de gas traqueal en paciente con tromboembolismo pulmonar masivo secundario a deficiencia de proteína C, S y de antitrombina III (AT III). Acta Colomb Cuid Intensivo. 2009;10(2):136-142.
Giraldo Sánchez JM, Villamarín R. Ventilación mecánica de alta frecuencia más insuflación de gas traqueal en paciente con síndrome de dificultad respiratoria del adulto secundario a aspiración masiva inducida por opioide. Acta Colomb Cuid Intensivo. 2008;8(4):312-317.
Giraldo Sánchez JM, Cantillo A, Puentes FE. Ventilación mecánica protectora e insuflación de gas traqueal en paciente con contusión pulmonar. Acta Colomb Cuid Intensivo. 2008;8(4):318-321.
van den Boogaard M, Pickkers P, Slooter AJ, Kuiper MA, Spronk PE, van der Voort PH, et al. Development and validation of PRE-DELIRIC (PREdiction of DELIRium in ICu patients) delirium prediction model for intensive care patients: observational multicentre study. BMJ. 2012;344:e420.
Ely EW, Truman B, Shintani A, Thomason JW, Wheeler AP, Gordon S, et al. Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS). JAMA. 2003;289(22):2983-2991.
Liu X, Zhang X, Xiao Y, et al. Heparin-induced thrombocytopenia is associated with a high risk of mortality in critical COVID-19 patients receiving heparin-involved treatment. medRxiv. 2020. Available in: https://www.medrxiv.org/content/10.1101/2020.04.23.20076851v1
Cai Z, Greene MI, Zhu Z, Zhang H. Structural features and PF4 functions that occur in heparin-induced thrombocytopenia (HIT) complicated by COVID-19. Antibodies (Basel). 2020;9(4):52. doi: 10.3390/antib9040052.
Poncz M, Surrey S, LaRocco P, Weiss MJ, Rappaport EF, Conway TM, et al. Cloning and characterization of platelet factor 4 cDNA derived from a human erythroleukemic cell line. Blood. 1987;69(1):219-223.
Barber AJ, Kaser-Glanzmann R, Jakabova M, Luscher EF. Characterization of a chondroitin 4 -sulfate proteoglycan carrier for heparin neutralizing activity (platelet factor 4) released from human blood platelets. Biochim Biophys Acta. 1972;286:312-329. doi: 10.1016/0304-4165(72)90267-X.
Holt JC, Niewiarowski S. Biochemistry of alpha granule proteins. Semin Hematol. 1985;22(2):151-163.
Qiu J, Ma J, Zhang S, Han J, Liu S. Promoting platelets is a therapeutic option to combat severe viral infection of the lung. Blood Adv. 2020;4(8):1640-1642. doi: 10.1182/bloodadvances.2020001669.
Salamanna F, Maglio M, Landini MP, Fini M. Platelet functions and activities as potential hematologic parameters related to Coronavirus Disease 2019 (Covid-19). Platelets. 2020;31(5):627-632. doi: 10.1080/09537104.2020.1762852.
Schrottmaier WC, Mussbacher M, Salzmann M, Assinger A. Platelet-leukocyte interplay during vascular disease. Atherosclerosis. 2020;307:109-120. doi: 10.1016/j.atherosclerosis.2020.04.018.
Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382(18):1708-1720. doi: 10.1056/NEJMoa2002032.
Bao C, Tao X, Cui W, Yi B, Pan T, Young KH, et al. SARS-CoV-2 induced thrombocytopenia as an important biomarker significantly correlated with abnormal coagulation function, increased intravascular blood clot risk and mortality in COVID-19 patients. Exp Hematol Oncol. 2020;9:16. doi: 10.1186/s40164-020-00172-4.
Patell R, Khan AM, Bogue T, Merrill M, Koshy A, Bindal P, et al. Heparin induced thrombocytopenia antibodies in Covid-19. Am J Hematol. 2020;95(10):E295-E296. doi: 10.1002/ajh.25935.
Riker RR, May TL, Fraser GL, Gagnon DJ, Bandara M, Zemrak WR, et al. Heparin-induced thrombocytopenia with thrombosis in COVID-19 adult respiratory distress syndrome. Res Pract Thromb Haemost. 2020;4(5):936-941. doi: 10.1002/rth2.12390.
Phan XT, Nguyen TH, Tran TT, Huynh TT, Hoang TT, Nguyen VV, et al. Suspected heparin-induced thrombocytopenia in a COVID-19 patient on extracorporeal membrane oxygenation support: a case report. Thromb J. 2020;18(1):37. doi: 10.1186/s12959-020-00252-9.
Uaprasert N, Tangcheewinsirikul N, Rojnuckarin P, Patell R, Zwicker JI, Chiasakul T. Heparin-induced thrombocytopenia in patients with COVID-19: a systematic review and meta-analysis. Blood Adv. 2021;5(21):4521-4534. doi: 10.1182/bloodadvances.2021005314.