Nandí LME, Ávila-Figueroa C

Language: Spanish
References: 56
Page: 182-191
PDF size: 123.95 Kb.

ABSTRACT

Treatment of pediatric patients VIH infected, has changed dramatically during the past years. The inclusion of protease inhibitors has resulted in benefits in virologic, immunologic and clinical effects such as reducing viral plasmatic concentration, increasing of CD4 count and weight as well as decreasing of opportunistic infections, hepatosplenomegaly and lymphadenopathy, also there is a reduction of encephalopathy due to VIH and a decrease in the number of hospital admissions.
Even with the use of combined triple therapy, also named Highly Active Antiretroviral Therapy (HAART), there is a number of patients with failure to treatment caused by viral resistance or appearance of mutant strains. Immaturity of immune system, differences in pharmacokinetics and pharmacodynamics and adherence to treatment makes difficult to evaluate results of treatment in children as compared to adults. For patients who failed to HAART therapy, the guidelines for antiretroviral therapy recommend treatment with two protease inhibitors or a protease inhibitor plus a nucleoside analogue. Strategies of treatment must be focused to early starting of therapy in order to reduce viral replication and development of resistance as well as maintaining the immune function.

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