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2002, Number 2

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Enf Infec Microbiol 2002; 22 (2)

Nosocomial infections by multiresistant Gram-positive cocci: Activity of new antimicrobial

Morfín OR, Donis HJ, Arredondo JL, Soriano D, Hermida C, Heredia CJ, Esparza AJ, Rodríguez NE

Language: Spanish
References: 39
Page: 55-61
PDF size: 61.35 Kb.


ABSTRACT

Background. Resistance in Gram-positive pathogens is a worldwide problem. The decrease of activity of available antibiotics has created a need for new antimicrobial agents. Linezolid is a member of the new class of antimicrobials, the oxazolidinones. Linezolid is active in vitro against staphylococci, streptococci, and Enterococci, including resistant strains such as methicillin-resistant S. aureus, penicillin-resistant Streptococcus pneumoniae, and vancomycin-resistant Enterococci.
Objective. To determine the in vitro activity of linezolid and other new antimicrobial active against gram-positive cocci.
Material and methods. Two hundred and ninety six Gram-positive cocci isolated from 4 different hospital in México in 2000 were analyzed. The susceptibility tests included a disk diffusion and the E test.
Results. All S. aureus (Oxa-S), S. aureus (Oxa-R), Staphylococcus sp (Oxa-s) and Staphylococcus sp (Oxa-R) were susceptible to linezolid, quinupristin-dalfopristinn and vancomycin. Some Staphylococcus sp (Oxa-R) were resistant to teicoplanin (15%) and to clindamycin (54%).
No vancomycin-resistant Enterococci were found. E. faecalis was frequently resistant to quinupristin-dalfopristin (89%). 50% of E. faecium were resistant to ampicillin. Resistance to penicillin in S. pneumoniae was 45%.
Conclusions. Linezolid is a new potential treatment option for resistant gram-positive infections.


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