medigraphic.com
ISSN 1561-3054 (Electronic)

2021, Number 3

<< Back Next >>

Rev Cubana Med Trop 2021; 73 (3)

Predisposing factors for complicated malaria in Cauca Department, Colombia

Obando VCR, Quiñones DJE, Mamian MDE, Gómez CC, Merchán-Galvis Á

Language: Spanish
References: 29
Page: 1-15
PDF size: 462.73 Kb.


ABSTRACT

Introduction: Malaria is a parasitic infection caused by protozoa of the genus Plasmodium. This condition may lead to organ dysfunction. Despite the actions implemented to control and prevent malaria, it continues to be a public health problem contributing to morbidity and mortality, mainly in tropical countries.
Objective: Identify the predisposing factors for complicated malaria in Cauca Department, Colombia.
Methods: An observational non-paired case-control study was conducted in Cauca Department in the period 2016-2019. The study sample was 445 patients notified to the National Public Health Surveillance System. Patients with complications were defined as cases (n= 89). Each case was assigned four controls (n= 356). Information about complicated cases was contrasted with the medical records.
Results: Of the total population studied (n= 445), 281 were men (63.1%) and 397 were from Cauca Department (89.2%). Mean age was 28.34 years. Ninety-nine patients required hospitalization (22.2%) and three died (0.7%). Sixty-one of the complicated patients were infected by P. falciparum (68.5%). The following factors were associated to complications: imported cases (p= 0.000), black ethnic group (p=0.000), treatment after three days (p= 0.000), urban area of residence (p= 0.025), contributory regime (p=0.026), P. vivax (p= 0.000) and presence of gametocytes (p=0.000).
Conclusions: Actions should be implemented concerning geographic location, inefficient hospital networks and insufficient knowledge about the disease, among other factors. Lack of studies about malaria and its complications limit decision making.


REFERENCES

  1. Fleta Zaragozano J. Paludismo: un grave problema de salud mundial. Med Integr [Internet]. 2001 [acceso: 01/09/2019];38(4):167-74. Disponible en: Disponible en: http://www.elsevier.es/es-revista-medicina-integral-63-articulo-paludismo-un-grave-problema-salud-13018801

  2. Eldh M, Hammar U, Arnot D, Beck HP, Garcia A, Liljander A, et al. Multiplicity of asymptomatic Plasmodium falciparum infections and risk of clinical malaria: a systematic review and pooled analysis of individual participant data. J Infect Dis. [Internet]. 2020 [acceso: 03/10/2019];221:775-85. Disponible en: Disponible en: https://academic.oup.com/jid/article/221/5/775/5581561

  3. WHO. Severe malaria. Tropical Medicine and International Health[Internet]. 2014 [acceso: 09/10/2019]. Disponible en: Disponible en: https://www.who.int/malaria/publications/atoz/severe-malaria-tmih-2014/en/

  4. Murillo-Palacios OL, Pedroza C, Bolaños C. Del Toro E, Cubillos J, Chaparro P, Mosquera M. Malaria complicada en el Chocó: hallazgos clínicos y comparación de datos con el sistema de vigilancia. Rev Salud Pública [Internet]. 2018;20(1):73-81. Doi: https://doi.org/10.15446/rsap.v20n1.50077

  5. WHO. World Malaria Report 2016. Geneva. [Internet]. 2016 [acceso: 03/11/2019]. Disponible en: Disponible en: http://apps.who.int/iris/bitstream/handle/10665/252038/9789241511711-eng.pdf?sequence=1

  6. OMS. Estrategia técnica mundial contra la malaria 2016-2030. [Internet]. 2015 [acceso: 23/09/2019]. Disponible en: Disponible en: https://apps.who.int/iris/bitstream/handle/10665/186671/9789243564999_spa.pdf?sequence=1

  7. Padilla-Rodríguez JC, Olivera MJ, Guevara-Garcıía BD. Parasite density in severe malaria in Colombia. PLOS ONE[Internet] 2020;15(6):e0235119. Doi: https://doi.org/10.1371/journal.pone.0235119

  8. Ministerio de Salud y Protección Social de Colombia. Chocó, Cauca, Nariño y Buenaventura prevalentes para malaria. Colombia. [Internet]. [acceso: 16/09/2019]. Disponible en: Disponible en: https://www.minsalud.gov.co/Paginas/choco-cauca-narino-y-buenaventura-prevalentes-para-malaria.aspx

  9. Instituto Nacional de Salud. BES Boletín epidemiológico semanal. Semana epidemiológica 52. 22 al 28 de diciembre de 2019. Colombia. [Internet]. [acceso: 16/09/2019]. Disponible en: Disponible en: http://www.ins.gov.co/buscador-eventos/BoletinEpidemiologico/2019_Boletin_epidemiologico_semana_52.pdf

  10. Tobón A. Signos de peligro en el paciente con malaria. Biomedica [Internet]. 2009;29(2):320-9. Doi: https://doi.org/10.7705/biomedica.v29i2.33

  11. Instituto Nacional de Salud. Guía protocolo para la vigilancia en salud pública de la malaria. Colombia. [Internet]. 2014 [acceso: 03/09/2019]. Disponible en: Disponible en: https://www.minsalud.gov.co/Documents/Salud%20P%C3%BAblica/Ola%20invernal/Protocolo%20Vigilancia%20MALARIA.pdf

  12. Parker DM, Tripura R, Peto TJ, Maude RJ, Nguon C, Chalk J. A multi-level spatial analysis of clinical malaria and subclinical Plasmodium infections in Pailin Province, Cambodia. Heliyon [Internet]. 2017;3(11):447. Doi: https://doi.org/10.1016/j.heliyon.2017.e00447

  13. Montiel J, Zuluaga LM, Aguirre DC. Microscopic and submicroscopic Plasmodium infections in indigenous and non-indigenous communities in Colombia. Malar J [Internet]. 2020;19-157. Doi: https://doi.org/10.1186/s12936-020-03226-4

  14. Hashim HA, Ali E. Pattern of malaria in hospitalized children in Khartoum state. Sudan J Paediatr [Internet]. 2017;17(2):35-41. Doi: https://doi.org/10.24911/SJP.2017.2.4

  15. Cook J, Owaga C, Marube E, Baidjoe A, Stresman G, Migiro R. Risk factors for Plasmodium falciparum infection in the Kenyan Highlands: a cohort study. RSTMH [Internet]. 2018;3:152-9. Doi: https://doi.org/10.1093/trstmh/try122

  16. Maestre R, Laborde C, Correa E, Cuadras L, Aramendiz K, Pareja P. Caracterización epidemiológica de pacientes con malaria, notificados por un asegurador en salud en Colombia, 2016-2017. Rev Cuba Med Tropical [Internet]. 2020 [acceso: 22/11/2019];72(1). Disponible en: Disponible en: http://www.revmedtropical.sld.cu/index.php/medtropical/article/view/436

  17. Favier TMA, Samón LM, Manuel YÁH, Chi CM, Dehesa GL. Paludismo, comportamiento en Banco de Urgencias del Hospital Municipal de Libolo, Kwansa Sul, Angola. RIC[Internet]. 2017 [acceso: 03/10/2019];96(6):1056-63. Disponible en: Disponible en: http://www.revinfcientifica.sld.cu/index.php/ric/article/view/1783

  18. Anvikar AR, van Eijk AM, Shah A, Upadhyay KJ, Sullivan SA, Patel AJ, et al. Clinical and epidemiological characterization of severe Plasmodium vivax malaria in Gujarat, India. Virulence [Internet]. 2020];11(1):730-8. Doi: https://doi.org/10.1080/21505594.2020.1773107

  19. Cortés LJ, Guerra AP. Análisis de concordancia de tres pruebas para el diagnóstico de malaria en la población sintomática de los municipios endémicos de Colombia. Biomédica [Internet]. 2020;40(1):117-28. Doi: https://doi.org/10.7705/biomedica.4893

  20. Ministerio de Salud y Protección Social de Colombia. Malaria [Internet]. Colombia. [acceso: 27/03/2021]. Disponible en: Disponible en: https://www.minsalud.gov.co/salud/publica/PET/Paginas/malaria.aspx

  21. Menendez Capote RL, Mungwahali Kaduli Y, Pomier Suárez O. Caracterización clínica del paludismo importado. Rev Cuba Med Tropical [Internet]. 2020 [acceso: 22/07/2020];72(2). Disponible en: Disponible en: http://www.revmedtropical.sld.cu/index.php/medtropical/article/view/459/

  22. Molineros Gallón LF, Calvache López O, Bolaños Ramírez H, Castillo Carol C, Torres Burbano C. Aplicaciones de un modelo integral para el estudio de la malaria urbana en San Andrés de Tumaco, Colombia. Rev Cuba Med Tropical [Internet]. 2014 [acceso: 16/01/2019];66(1):3-19. Disponible en: Disponible en: http://www.revmedtropical.sld.cu/index.php/medtropical/article/view/2/

  23. Kotepui M, Kotepui KU, Milanez GD, Masangkay FR. Severity and mortality of severe Plasmodium ovale infection: A systematic review and meta-analysis. PLoS ONE [Internet]. 2020;15(6):e0235014. Doi: https://doi.org/10.1371/journal.pone.0235014

  24. Van Eijk AM, Mannan AS, Sullivan SA. Defining symptoms of malaria in India in an era of asymptomatic infections. Malar J [Internet]. 2020;19:237. Doi: https://doi.org/10.1186/s12936-020-03310-9

  25. Val F, Avalos S, Gomes AA, Albornoz Zerpa JE, Fontecha G, Siqueira AM, et al. Are respiratory complications of Plasmodium vivax malaria an underestimated problem? Malar J [Internet]. 2017;16:495. Doi: https://doi.org/10.1186/s12936-017-2143-y

  26. Ministerio de Salud. Factores de riesgo de la paludismo grave en el Perú [Internet]. Perú: Ministerio de salud; 2001 [acceso: 12/11/2017]. Disponible en: Disponible en: http://bvs.minsa.gob.pe/local/minsa/1772.pdf

  27. Lara A. Malaria complicada y no complicada. Revista Médica Clínica del Country [Internet]. 2015 [acceso: 25/03/2021];5(1). Disponible en: Disponible en: https://revistamedicaclcountry.com/app/default/files-module/local/documents/Malaria-complicada-y-no-complicada.pdf

  28. OMS. Paludismo [Internet]. [acceso: 25/03/2021]. Disponible en: Disponible en: https://www.who.int/malaria/areas/treatment/overview/es/

  29. Tobón A, Giraldo C, Pineros JG, Arboleda M, Blair S, Carmona-Fonseca J. Epidemiologia de la malaria falciparum complicada: estudio de casos y controles en Tumaco y Turbo, Colombia, 2003. Rev Bras Epidemiol [Internet]. 2006;9(3):283-96. Doi: http://dx.doi.org/10.1590/S1415-790X2006000300003




2020     |     www.medigraphic.com