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2022, Number 4

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Rev Educ Bioquimica 2022; 41 (4)

El proteosoma: su interregulación con el citoesqueleto de actina y sus alteraciones en patologías

Martínez PD, Gómez CKA, Sosa GM, Macías SM

Language: Spanish
References: 43
Page: 140-153
PDF size: 576.99 Kb.


ABSTRACT

The proteostasis or protein homeostasis is an important process for normal cellular function in which the protein degradation is crucial. The Ubiquitin-Proteosome System (UPS) degrades many proteins in cells. UPS efficient function depends on a tight regulation of UPS assembly. Recently, changes on cell polarity and actin cytoskeleton dynamics have been shown to be related to protein stability regulation by controlling some UPS components. This review describes and analizes recent information on the interregulation between the proteosome and actin cytoskeleton dynamic to understand its relevance in cellular homeostasis. Furthermore, it gives evidence UPS malfunction leads to the development of various human diseases; thus, the proteosome is currently considered an important theurapeutic target.


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