2003, Number s1
<< Back Next >>
Gac Med Mex 2003; 139 (s1)
Management of Spontaneous Abortion and Its Complications
Menéndez VJF
Language: Spanish
References: 51
Page: 47-54
PDF size: 86.93 Kb.
ABSTRACT
Reproduction in humans is a quite inefficient function, with general pregnancy losses of 50-75%; when diagnosis of pregnancy has been established, the proportion of pregnancy losses may vary from 15-20%. Early diagnosis of pregnancy is usually made employing highly sensitive immunoassays for the β-subunit of chorionic gonadotropin and by ultrasonography. Both methods also allow to classify spontaneous abortion as early and late, and its causes include genetic abnormalites (the most frequent), progesterone deficiency, diabetes mellitus, polycystic ovary syndrome, subchorionic hematoma, infections, etc. Although management usually involves dilatation and curettage, medical treatment with misoprostol or methotrexate, or by manual vacuum aspiration, is currently widely accepted. The most frequent complications are transvaginal bleeding, pain, conceptus retention, infections, and uterine perforation. Psychological complications are not rare.
REFERENCES
Boklage CE. Survival probability of human conceptions from fertilization to term. Int J Fertil 1990;35:75-94.
Wilcox AJ, Weinberg CR. Incidence of early loss of pregnancy. N Engl J Med 1988;319:189-194.
Fantel AG, Shepard TH. Morphological analysis of spontaneous abortuses. In: Bennett MJ, Edmonds DK, editors. Spontaneous and recurrent abortion. Oxford, UK: Blackwell Scientific Publications;1987. pp. 8-28.
Kline J, Stein Z. Epidemiology of chromosomal anomalies in spontaneous abortion. In: Bennett MJ, Edmonds DK. editors. Spontaneous and recurrent abortion. Oxford, UK: Blackwell Scientific Publications;1987. pp. 29-50.
ACOG. Technical Bulletin. Early pregnancy loss. Number 212 Sep. 1995.
Warburton D, Kline J. Does the karyotype of a spontaneous abortion predict the karyotype of a subsequent abortion? Am J Hum Genet 1987;41:465-83.
Breth VK, Hanes V. Prognosis of a new pregnancy following previous spontaneous abortions. Eur J Obstet Gynecol Reprod Biol 1991;39:31-36.
Eiben B, Bartels I. Cytogenetic analysis of 750 spontaneous abortions with direct-preparation method of chorionic villi and its implications for studying genetic causes of pregnancy wastage. Am J Hum Genet 1990;47:656-663.
Balasch J, Creus M. The significance of luteal phase deficiency on fertility: a diagnostic and therapeutic approach. Hum Reprod 1986;1:145.
Mills JL, Simpson JL. Incidence of spontaneous abortion among normal women and insulin dependent diabetic women whose pregnancies were identified within 21 days of conception. N Engl J Med 1988;319:1617-1623.
Sagle M, Bishop K. Recurrent early miscarriage and polycystic ovary. Br Med J 1988;297:1027-1028.
Johnson P, Pearce JM. Recurrent spontaneous abortion and polycystic ovary disease. Br Med J 1990;300:154-156.
Pedersen JF, Mantoni M. Large intrauterine haematomata in threatened miscarriage: frequency and clinical consequences. Br J Obstet Gynaecol 1990;97:75.
Tower CL, Regan L. Intrauterine haematomas in a recurrent miscarriage population. Hum Reprod 2001;16(9):2005-2007.
Quin PA, Chewchuck AB. Efficacy of antibiotic therapy in preventing spontaneous pregnancy loss among couples colonized with genital mycoplasma. Am J Obstet Gynecol 1983;145:239-244.
Golan A, Langer RM. Cervical cerclage: its role in the pregnant anomalous uterus. Int J Fertil 1990;35:164.
Feingold M, Brook I. Detection of cervical incompetence by ultrasound. Acta Obstet Scand 1984;63:407.
Branch DW. Antiphospholipid antibodies and pregnancy: maternal implications. Semin Perinatol 1990;14:139-146.
Empson M, Lassere M. Recurrent pregnancy loss with antiphospholipid antibody. A systematic review of therapeutic trials. Obstet Gynecol 2002;99:135-144.
Bastian LA, Piscitelli JT. Is this patient pregnant? Can you reliably rule in or rule out early pregnancy by examination?. JAMA 1997;278:586-591.
Robinson ET, Barber JH. Early diagnosis of pregnancy in general practice. J R Coll Gen Pract 1977;27:335-338.
Zabin lS, Emerson MR. Adolescents with negative pregnancy test results: an accessible at risk group. JAMA 1996;275:113-117.
Warburton D, Frasier F. Spontaneous abortion risks in man: data from reproductive histories collected in a medical genetics unit. Am J Hum Genet 1964;16:1-12.
Kadar N, Boher M. A prospective randomized study of the chorionic gonadotropin-time relationship in early gestation: a clinical implications. Fertil Steril 1993;60:409-412.
Chard T. Pregnancy tests: a review. Hum Reprod 1992;7:701-710.
Norman RJ, Menabawey M. Relationship between blood and urine concentrations of intact human chorionic gonadotropin and its free subunits in early pregnancy. Obstet Gynecol 1987;69:590-593.
Daviaud J, Fournet D. Reliability and feasibility of pregnancy home-use test: laboratory validation and diagnostic evaluation by 638 volunteers. Clin Chem 1993;39:53-59.
LaGrew DC, Wilson EA. Determination of gestational age by serun concentrations of human chorionic gonadotropin. Obstet Gynecol 1983;62:37-40.
Steinkampf MP, Guzkick DS. Identification of early pregnancy landmarks by transvaginal sonography: analysis by logistical regression. Fertil Steril 1997;68:168-170.
Nyberg DA, Laing FC. Ultrasonographic differentiation of the gestational sac of early intrauterine pregnancy from the pseudogestational sac of ectopic pregnancy. Radiology 1983;146:755-759.
Nyberg DA, Mark lA. Early pregnancy complications: endovaginal sonographic findings correlated with human gonadotropin levels. Radiology 1988;167:619-622.
Bree RL, Edwards M. Transvaginal sonography in the evaluation of normal early pregnancy: correlation with Hgc level. Am J Roentgenol 1989;153:75-79.
Hellman LM, Kobayashi M. Growth and development of human fetus prior to the twentieth week of gestation. Am J Obstet Gynecol 1969;103:789-800.
Rossavik IK, Torjusen GO. Conceptual age and ultrasound measurements of gestational sac and crown-rump length in “in vitro” fertilization pregnancies. Fertil Steril 1988;49:1012-1017.
Daya S, Woods S. Early pregnancy assessment with transvaginal ultrasound scanning. CMAJ 1991;144:441-446.
Goldstein SR. Significance of cardiac activity on endovaginal ultrasound in very early embryos. Obstet Gynecol 1992;80:670-672.
Spitz IM, Bardin CW. Early pregnancy termination with mifepristone and misoprostol in the United States. N Engl J Med 1998;338:1241-1247.
Peyron R, Aubeny E. Early termination of pregnancy with mifepristone (RU 486) and the orally active prostaglandin misoprostol. N Engl J Med 1993;328:1509-1513.
Aubeny E, Peyron R. Termination of early pregnancy (up to 63 days of amenorrhea) with mifepristone and increasing doses of misoprostol. Int J Fertil Menopausal Stud 1995;40 (Suppl 2):85-91.
Wood SL, Brain PH. Medical management of missed abortion: a randomized clinical trial. Obstet Gynecol 2002;99(4):563-566.
Carbonell JL, Velazco A. Misoprostol 3, 4 or 5 days after methotrexate for early abortion: a randomized trial. Contraception 1997;56:169-174.
Greenslade F, Leonard A. Manual vacuum aspiration: a summary of clinical and programatic experience woridwide. Ipas monograph. Carrborro, NC, USA: Ipas;1993.
Jermyk LC. Outcome of expectant management of spontaneous first trimester miscarriage: observational study. Br Med J 2002;324(7342):873-875.
Ballagh SA, Harris HA. Is curettage needed for uncomplicated incomplete spontaneous abortion? Am J Obstet Gynecol 1998;179(5):1279-1282.
Kruse B, Poppema S. Management of side effects and complicactions in medical abortion. Am J Obstet Gynecol 2000;183(Suppl 2): S65-S75.
Johnson JE. Effects of accurate expectations about sensations on the sensory and distress components of pain. J Pers Soc Psychol 1973;27:261-275.
Ashok PW, Penney GC. An effective regimen for early medical abortion: a report of 2000 consecutive cases. Human Reprod 1998;13:2962-2965.
Hakim-Elahi E, Tovell HM. Complications of first-trimester abortion: a report of 170,000 cases. Obstet Gynecol 1990;76:129-135.
Programa Clinos. IASIST Méx. Grupos Relacionados con el Diagnostico (GRD). México: Hospital de Ginecoobstetricia “Luis Castelazo Ayala” IMSS; 1999-2002.
Conway K, Russell G. Couples grief and experience of support in the aftermath of miscarriage. Br J Med Psychol 2000; 73(4):531-545.
Neugebauer R, Kline J. Major depressive disorder in the 6 months after miscarriage. JAMA 1997;277(5):383-388.