2023, Number 1
Presence of anti-spike IgG antibodies to COVID-19 in newborns of vaccinated mothers at Hospital Angeles Pedregal
Language: Spanish
References: 12
Page: 55-59
PDF size: 163.50 Kb.
ABSTRACT
Introduction: there is little information on the amount of anti-spike IgG antibodies for COVID-19 that are passed to the newborn through vaccination of pregnant mothers. Material and methods: cross-sectional, descriptive and analytical study carried out in the Neonatology Service of Hospital Angeles Pedregal, where newborns of mothers who complied with the vaccination schedule were collected from November 2021 to May 2022. Results: there were 106 patients where it was found that 75.5% (80/106) had a vaccine with an mRNA mechanism. They presented the following average number of antibodies per vaccine: Moderna (15,324.4), Sputnik (13,498), Pfizer-BioNTech (11,635), and AstraZeneca (4,831.9). According to trimester of pregnancy the following numbers were: first (6,395-15,020), second (9,302-25,131) and third (4,843-9,440). Receiving an additional dose of vaccination presents the following values compared to those who did not receive a booster (18,235 vs 7,311). Conclusions: it is vitally important to vaccinate pregnant women during pregnancy with any type of vaccine. It can be verified that the gestation trimester in which the greatest number of antibodies passes to the newborn is the second trimester. Receiving an additional dose of vaccination provides a significant increase in the number of antibodies present at birth.REFERENCES
Rottenstreich A, Zarbiv G, Oiknine-Djian E, Zigron R, Wolf DG, Porat S. Efficient maternofetal transplacental transfer of anti- severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike antibodies after antenatal SARS-CoV-2 BNT162b2 messenger RNA vaccination. Clin Infect Dis. 2021; 73 (10): 1909-1912.
Yang YJ, Murphy EA, Singh S, Sukhu AC, Wolfe I, Adurty S et al. Association of gestational age at coronavirus disease 2019 (COVID-19) vaccination, history of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and a vaccine booster dose with maternal and umbilical cord antibody levels at delivery. Obstet Gynecol. 2022; 139 (3): 373-380.