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2021, Number 3

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Correo Científico Médico 2021; 25 (3)

Cancer treatment based on epigenetics

Rodríguez MY, Expósito LA, Hernández CJA, Valdés CRC

Language: Spanish
References: 42
Page:
PDF size: 707.53 Kb.


ABSTRACT

Cancer is a multifactorial disease that involves genetic, epigenetic and environmental factors in a complex and not well understood interrelationship. Epigenetics, which does not affect the sequence of nitrogenous bases in DNA, is a promising field for the development of new therapies against cancer. A literature review was conducted in PubMed/Medline (https://pubmed.ncbi.nlm.nih.gov), regional SciELO (https://scielo.org/es) and Cochrane Library (https://www.cochranelibrary.com). Original articles, literature reviews, systematic reviews, meta-analyses and clinical trials, published preferably in the last 5 years, were the ones chosen. Some of the DNA methylation inhibitors used are azacitidine, decitabine, enasidenib and ivosidenib. The approved histone deacetylase inhibitors are panobinostat, bortezomib, belinostat, romidepsin and vorinostat; the most common histone methylation/demethylation inhibitors are tazemetost, EPZ00477 and pinometostat. Non-coding RNA-based therapies are also used.


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