Language: Spanish
References: 0
Page: 12-12
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ABSTRACT

Introduction: in Mexico, the diagnostic approach to patients with allergic diseases focuses on determining the profile of allergic sensitization (specific IgE) directed at allergenic extracts. Molecular allergy represents a precision medicine tool where sensitization to the allergen (mainly allergenic proteins) is established in a timely manner, which allows further diagnostic precision, therapeutic decision-making and patient prognosis. Currently we already have access to in vitro determination of the sensitization profile towards allergens that have shown greater clinical relevance. Objective: to present the Mexican Molecular Allergy Guideline, which covers topics that describe the molecular structures of allergens, the clinical relevance of knowing which allergenic families the allergens studied in patients belong to, laboratory techniques for their determination and analysis, the characteristics of the clinically relevant allergens and also, flow charts for decision making in the selection and interpretation of the results obtained. Material and methods: with the participation of professionals, both allergists and other specialists in related areas, experts and opinion leaders on the subject, published international documents were reviewed: the molecular allergy consensus issued by the World Allergy Organization and the molecular allergy manuals published by the European Academy of Allergy, Asthma and Clinical Immunology (version 1 and 2) and by the German Allergy Society. The allergens that are commercially available in Mexico were selected to facilitate knowledge about the selection and interpretation grounded in daily clinical practice. Results: for the first time in a Mexican academic document, an exhaustive description of allergens is presented from the molecular point of view. A clinical orientation is issued, as well as points of good practice that will impact on the approach to our patients with IgE-mediated allergy. Conclusions: a large group of experts in molecular allergology facilitate access to complete and practical information regarding the approach to patients with IgE-mediated allergy, whose molecular diagnosis improves the approach.