2022, Number 3
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Rev Neurol Neurocir Psiquiat 2022; 50 (3)
Development of a widely available odor identification test
Robledo-Rengifo S, Agudelo-Uribe MP, Ospina-Giraldo JM, Saavedra-Moreno JS, Isaza-Jaramillo SP
Language: Spanish
References: 24
Page: 88-93
PDF size: 166.36 Kb.
ABSTRACT
Introduction: hyposmia is an early marker of some neurodegenerative diseases. Odor identification tests are expensive and contain odors that may be poorly known in some cultures. It is important to standardize tests that are easy to apply in Spanish-speaking countries.
Material and methods: descriptive observational study of identification of coffee, cloves, cinnamon and sugar in 100 adults without diseases that affect olfaction. Individual commercial packages were utilized, and free responses by each subject were recorded.
Results: coffee and cinnamon were identified by 83% and 71% of subjects, respectively. Cloves and sugar were poorly identified. Less than 2/3 of people older than 60 years recognized coffee and cinnamon.
Conclusions: most of the subjects identify two of the four odors contained in this test. We propose that subjects with identification of 1 or none of the odors require undergoing a more comprehensive evaluation. The effects of age, also described in other publications, suggests that in older subjects it would be necessary to use tests with a greater number of odors to differentiate between age-associated loss of smell and hyposmia associated with neurodegenerative diseases.
REFERENCES
Doty RL. Olfactory dysfunction and its measurement in the clinic. World J Otorhinolaryngol Head Neck Surg. 2015; 1 (1): 28-33.
Doty RL, Deems DA, Stellar S. Olfactory dysfunction in parkinsonism: a general deficit unrelated to neurologic signs, disease stage, or disease duration. Neurology. 1988; 38 (8): 1237-1237.
Fullard ME, Morley JF, Duda JE. Olfactory dysfunction as an early biomarker in Parkinson's disease. Neurosci Bull. 2017; 33 (5): 515-525.
Ponsen MM, Stoffers D, Twisk JWR, Wolters ECh, Berendse HW. Hyposmia and executive dysfunction as predictors of future Parkinson's disease: a prospective study: Predictors of Future PD. Mov Disord. 2009; 24 (7): 1060-1065.
Berg D, Godau J, Seppi K, Behnke S, Liepelt-Scarfone I, Lerche S et al. The PRIPS study: screening battery for subjects at risk for Parkinson's disease. Eur J Neurol. 2013; 20 (1): 102-108.
Alonso CCG, Silva FG, Costa LOP, Freitas SMSF. Smell tests to distinguish Parkinson's disease from other neurological disorders: a systematic review and meta-analysis. Expert Rev Neurother. 2021; 21 (3): 365-379.
Quagliato LB, Viana MA, Quagliato EM, Simis S. Olfaction and essential tremor. Arq Neuropsiquiatr. 2009; 67 (1): 21-24.
Postuma RB, Berg D, Stern M, Poewe W, Olanow CW, Oertel W et al. MDS clinical diagnostic criteria for Parkinson's disease: MDS-PD clinical diagnostic criteria. Mov Disord. 2015; 30 (12): 1591-1601.
Schmidt N, Paschen L, Witt K. Invalid self-assessment of olfactory functioning in Parkinson's disease patients may mislead the neurologist. Mirabella G, editor. Parkinsons Dis. 2020; 2020: 1-5.
Leonhardt B, Tahmasebi R, Jagsch R, Pirker W, Lehrner J. Awareness of olfactory dysfunction in Parkinson's disease. Neuropsychology. 2019; 33 (5): 633-641.
Doty RL, Shaman P, Kimmelman CP, Dann MS. University of Pennsylvania smell identification test: a rapid quantitative olfactory function test for the clinic. Laryngoscope. 1984; 94 (2): 176-178.
Doty RL, Marcus A, William Lee W. Development of the 12-item cross-cultural smell identification test (CC-SIT). Laryngoscope. 1996; 106 (3): 353-356.
Hummel T, Sekinger B, Wolf SR, Pauli E, Kobal G. 'Sniffin' Sticks': olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold. Chem Senses. 1997; 22 (1): 39-52.
Collins GS, Ogundimu EO, Altman DG. Sample size considerations for the external validation of a multivariable prognostic model: a resampling study: sample size considerations for validating a prognostic model. Stat Med. 2016; 35 (2): 214-226.
Langstaff L, Pradhan N, Clark A, Boak D, Salam M, Hummel T et al. Validation of the olfactory disorders questionnaire for English-speaking patients with olfactory disorders. Clin Otolaryngol. 2019; 44 (5): 715-728.
Silveira-Moriyama L, Carvalho M de J, Katzenschlager R, Petrie A, Ranvaud R, Barbosa ER et al. The use of smell identification tests in the diagnosis of Parkinson's disease in Brazil. Mov Disord. 2008; 23 (16): 2328-2334.
Rodríguez-Violante M, Gonzalez-Latapi P, Camacho-Ordoñez A, Martínez-Ramírez D, Morales-Briceño H, Cervantes-Arriaga A. Low specificity and sensitivity of smell identification testing for the diagnosis of Parkinson's disease. Arq Neuropsiquiatr. 2014; 72 (1): 33-37.
Rodríguez-Violante M, Gonzalez-Latapi P, Camacho-Ordoñez A, Martínez-Ramírez D, Morales-Briceño H, Cervantes-Arriaga A. Comparing the accuracy of different smell identification tests in Parkinson's disease: relevance of cultural aspects. Clin Neurol Neurosurg. 2014; 123: 9-14.
Hudson L, Silva MC, Núñez JC, Gómez R, Venegas-Francke P. Valores normales de olfato, hiposmia y anosmia en población chilena sana según la batería "sniffin sticks". Rev Méd Chile. 2012; 140 (4): 442-446.
Santin R, Fonseca VF, Bleil CB, Rieder CR, Hilbig A. Olfactory function and Parkinson's disease in Southern Brazil. Arq Neuropsiquiatr. 2010; 68 (2): 252-257.
Doty RL. Olfactory dysfunction in the elderly and in Alzheimer's disease. Olfaction and taste XI. 1994, pp. 597-601.
Murphy C. Prevalence of olfactory impairment in older adults. JAMA. 2002; 288 (18): 2307-2312.
Seubert J, Laukka EJ, Rizzuto D, Hummel T, Fratiglioni L, Backman L et al. Prevalence and correlates of olfactory dysfunction in old age: a population-based study. J Gerontol A Biol Sci Med Sci. 2017; 72 (8): 1072-1079.
Joseph T, Auger SD, Peress L, Rack D, Cuzick J, Giovannoni G et al. Screening performance of abbreviated versions of the UPSIT smell test. J Neurol. 2019; 266 (8): 1897-1906.