medigraphic.com
ISSN 2007-8013 (Print)
Órgano oficial de la Universidad Autónoma de Sinaloa

2019, Number 4

<< Back Next >>

Rev Med UAS 2019; 9 (4)

Clinical and histopathological study of basal cell carcinoma in individuals under 40 years of age

Verdugo-Castro PN, Muñoz-Estrada VF, Gaxiola-Álvarez EA

Language: Spanish
References: 25
Page: 192-201
PDF size: 340.04 Kb.


ABSTRACT

Objective. Clinical and histological description of basal cell carcinoma in patients under 40 years old. Material and methods. Observational, descriptive, retrospective and transversal study in individuals under 40 years old with clinic and histologic diagnosis of basal cell carcinoma in the Hospital Civil of Culiacan from January 1, 1994 to December 31, 2017. Results. We studied 1078 patients of whom 15.83% (n = 171) corresponded to individuals under 40 years old. The average age was 35 years. Female sex was affected by 57%. Phototype III was most frequent in 44%. 100% of cases occurred in head and of this, nose was the most affected area in 66%. Nodular morphology predominated at 63%. The most common histological pattern was solid in 58% but the aggressive histological variants corresponded to 41% (basosquamous, mixed, adenoid, morpheiform and superficial form). Conclusions. Basal cell carcinoma is common in the state of Sinaloa Mexico and with a high percentage of aggressive histological forms in individuals unde r 40 years old.


REFERENCES

  1. Marzuka AG, Book SE. Basal cell carcinoma:pathogenesis, epidemiology, clinical features,diagnosis, histopathology, and management.Yale J Biol Med. 2015;88(2):167.

  2. Saúl-Cano A. Saúl Lecciones de Dermatología.16a. Edición. México: Mc Graw Hill; 2015. p. 300-340.

  3. Falto AL, Griffith R, Simmons B, Nouri K. Thehistory of skin cancer. J Am Acad Dermatol.2015;72(5):AB27-AB27.

  4. Forman D, Bray F, Brewster DH, Gombe MC,Kohler B, Piñeros M, et al. Cancer Incidence inFive Continents Vol. X. IARC. 2014;164:1-1436.

  5. Siegel RL, Miller KD, Jemal A. Cancer statistics,2016. CA Cancer J Clin. 2016;66(1):7-30.

  6. Verkouteren J, Ramdas K, Wakkee M, NigstenT. Epidemiology of basal cell carcinoma:scholarly review. Br J Dermatol 2017;177(2):359-372.

  7. Skoda A, Simovic D, Karin V, Kardum V, VranicS, Serman L. The role of the Hedgehog signalingpathway in cancer: A comprehensive review.Bosn J Basic Med Sci. 2018;18(1):8-20.

  8. Montagna E, Lópes O. Molecular basis of basalcell carcinoma. An Bras Dermatol.2017;92(4):517-20.

  9. Bolognia JL, Schaffer JV, Cerroni L.Dermatology. 4th. Edition. U. S. A.: Mosby; 2018.p. 1872-1893.

  10. Patterson J. Weedon´s Skin Pathology. 4thEdition. U. S. A.: Elsevier; 2016. p. 504-524.

  11. Bichakjian C, Olencki T, Aasi S, Alam M,Andersen J, Blitzblau R, et al Basal Cell SkinCancer, Version 1.2016, NCCN Clinical PracticeGuidelines in Oncology. J Natl Compr CancNetw. 2016;14(5):574-97.

  12. Alter M, Hillen U, Leiter U, Sachse M, GutzmerR. Current diagnosis and treatment of basal cellcarcinoma. J Dtsh Dermatol Ges.2015;13(9):863-875.

  13. Calonje JE, Brenn T, Lazar AJ, McKee PH.McKee´s Pathology of the Skin. 5th Edition. U. S.A.: Elsevier; 2018. p. 1156-1233.

  14. Martínez-Guerra EC, Sánchez-Uriarte ME,Medina-Bojórquez A, Torres S, Alcalá-Pérez D.Cáncer de piel en pacientes menores de 40años. Dermatol Rev Mex. 2017;61(1):3-9.

  15. Hernández MÁC, Castellanos AP, Arias LF,García VA. Prevalencia de patrones histológicosagresivos de carcinoma basocelular enpacientes menores de 40 años. Experiencia decinco años en el Hospital General de México.Dermatol Rev Mex. 2013;57(3):149-154.

  16. Díaz GJM, Peniche CA, Fierro AL, Ponce ORM.Cáncer de piel en pacientes menores de 40años. Experiencia de cuatro años en el HospitalGeneral de México. Gac Méd Méx. 2011;147:17-21.

  17. Cox N. Basal cell carcinoma in young adults. BrJ Dermatol. 1992;127:26-29.

  18. Cabello I. Carcinoma Basocelular en Adultosjóvenes. Derm Venez.1996;34:53-55.

  19. Pearce M, Parker L, Cotterill J, Gordon P, CraftA. Melanoma Res. 2003;13:421–426.

  20. Christenson LJ, Borrowman TA, Vachon CM,Tollefson MM, Otley CC, Weaver AL, et al.Incidence of basal cell and squamous cellcarcinomas in a population younger than 40years. JAMA. 2005; 294(6):681-690.

  21. Arellano I, Alcalá D, Barba J, Carlos B,Castanedo J, De La Barreda F, et al.Recomendaciones clínicas para lafotoprotección en México. Dermatol Cosm MedQuir. 2014;12(4):243-255.

  22. Delfino S, Innocenzi D, Di Lorenzo G, ScalvenziM, Montesarchio V, Feroce F, et al. An Increasein Basal Cell Carcinoma among the Young: anEpidemiological Study in a Middle-South ItalianPopulation. Anticancer Res. 2006;26:4979-4984.

  23. Leffel D, Headington J, Wong D, Swanson N.Aggressive-Growth Basal Cell Carcinoma inYoung Adults. Arch Dermatol. 1991;127:1663-1667.

  24. Berlin NL, Cartmel B, Leffell DJ, Bale AE, MayneST, Ferrucci LM. Family history of skin cancer isassociated with early-onset basal cell carcinomaindependent of MC1R genotype. CancerEpidemiol. 2015;39(6),1078-1083.

  25. Dessinioti C, Tzannis K, Sypsa V, Nikolaou V,Kypreou K, Antoniou C, et al. Epidemiologic riskfactors of basal cell carcinoma development andage at onset in a Southern European populationfrom Greece. Exp Dermatol. 2011;20(8):622-626.




2020     |     www.medigraphic.com