2022, Number 11
Update on Watch and Wait management in rectal cancer
Language: Spanish
References: 18
Page:
PDF size: 192.98 Kb.
ABSTRACT
The treatment of rectal cancer continues to be mainly surgical, however, this management entails a series of comorbidities and possible complications for the patient, such as: fecal or urinary incontinence, sexual dysfunction and a high possibility of a permanent ostomy and its complications. However, it has been seen that up to a quarter of pathological specimens show a complete pathological response after neoadjuvant therapy. This is why, with the idea of avoiding these complications after surgery, the idea of Watch and Wait management was born. Where, if after neoadjuvant treatment the patient obtains a complete response to treatment, he or she goes on to a program of close observation and, if maintained, would avoid radical surgery, which in various studies has shown oncological results similar to surgical management. Being a novel management, it requires clarifying various aspects, including: the patient who would benefit the most, the neoadjuvant therapy to be performed, the evaluation of the clinical response and the follow-up of the patient.REFERENCES
Tulin A, Nitipir C, Slavu I, Braga V, Mihaila D, Alecu L. Watch and Wait Strategy for Rectal Cancer: 15 Years After the First Published Study. Are We any Closer to the Non-operative Management of Rectal Cancer? Revista Chirurgia [Internet]. 2019 [cited Aug 27, 2022];114(2):174. Available from: http://www.revistachirurgia.ro/pdfs/2019-2-174.pdf
Fokas E, Appelt A, Glynne-Jones R, Beets G, Pérez R, García-Aguilar J, et al. International consensus recommendations on key outcome measures for organ preservation after (chemo)radiotherapy in patients with rectal cancer. Nat Rev Clin Oncol [Internet]. Dec, 2021 [cited Sep 1, 2022];18(12):805–16. Available from: https://www.nature.com/articles/s41571-021-00538-5
Haak HE, Maas M, Lambregts DMJ, Beets-Tan RGH, Beets GL, Melenhorst J, et al. Is watch and wait a safe and effective way to treat rectal cancer in older patients? European Journal of SurgicalOncology [Internet]. Mar, 2020 [cited Sep 1, 2022];46(3):358–62. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0748798320300056
Glynne-Jones R, Wyrwicz L, Tiret E, Brown G, Rödel C, Cervantes A, et al. Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology [Internet]. Jul, 2017 [cited Jul 31, 2022];28:iv22–40. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0923753419421522
Cercek A, Roxburgh CSD, Strombom P, Smith JJ, Temple LKF, Nash GM, et al. Adoption of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer. JAMA Oncol [Internet]. Jun 14, 2018 [cited Aug 28, 2022];4(6):e180071. Available from: http://oncology.jamanetwork.com/article.aspx?doi=10.1001/jamaoncol.2018.0071
Pascual-Russo A, Milito D, Facio L, Furia M, Forestier V, Iseas S, et al. Mejor calidad de vida y menor incontinencia fecal en pacientes con cáncer de recto con la estrategia de seguimiento watch and wait. Revista de Gastroenterología de México [Internet]. Oct, 2021 [citado el 03 de setiembre, 2022];86(4):340–7. Disponible a partir de: https://linkinghub.elsevier.com/retrieve/pii/S0375090620300902