2022, Number 3
<< Back Next >>
Dermatología Cosmética, Médica y Quirúrgica 2022; 20 (3)
Lineal erythematous painful plaque (LEPP) rule in herpes zoster infection: a simple clinical observation
Silva LE
Language: English
References: 22
Page: 318-322
PDF size: 414.84 Kb.
ABSTRACT
Herpes zoster, or shingles, is a localized disease characterized
by unilateral radicular pain and a rash limited to the area of
skin innervated by a single dorsal root or cranial sensory ganglion.
Whereas varicella, or chickenpox, results from primary
exogenous varicella-zoster virus (VZV) infection, herpes zoster
is caused by reactivation of latent endogenous VZV. Early diagnosis
of herpes zoster is characterized by: lineal, ererythematous,
painful, plaque (LEPP rule) in the first 24 to 72 hours, it has
a favorable impact on instituting early treatment, reduces the
severity of the disease and prevents the appearance of postherpetic
neuralgia. Four immunocompetent patients with positive
LEPP rule are presented.
REFERENCES
Hope-Simpson RE, The nature of herpes zoster: a long-term studyand a new hypothesis, Proc R Soc Med 1965; 58:9-20. Available at:http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1898279&blobtype=pdf. Accessed April 8, 2009.
Head H and Campbell AW, The pathology of herpes zoster and itsbearing on sensory localisation, Brain 1900; 23:353-523.
Gnann JW Jr and Whitley RJ, Herpes zoster [review], N Engl J Med2002; 347:340-6.
Weller TH, Varicella and herpes zoster: a perspective and overview, JInfect Dis 1992; 166(suppl 1):s1-6.
Preblud SR, Orenstein WA and Bart KJ, Varicella: clinical manifestations,epidemiology, and health impact in children, Pediatr Infect Dis1984; 3:505-9.
Levin MJ, Oxman MN, Zhang JH, Johnson GR, Stanley H, HaywardAR et al., Veterans Affairs Cooperative Studies Program Shingles Prevention Study Investigators. Varicella-zoster virus-specific immuneresponses in elderly recipients of a herpes zoster vaccine, J Infect Dis2008; 197:825-35.
Oxman MN, Levin MJ, Johnson GR, Schmader KE, Straus SE, Gelb LDet al., Shingles Prevention Study Group. A vaccine to prevent herpeszoster and postherpetic neuralgia in older adults, N Engl J Med 2005;352:2271-84. Available at: http://content.nejm.org/cgi/content/full/352/22/2271. Accessed April 8, 2009.
Oxman MN, Clinical manifestations of herpes zoster. In: Arvin AM,Gershon AA (eds.), Varicella-zoster virus: virology and clinical management,Cambridge, England, Cambridge University Press, 2000, pp. 246-75.
Cohen JI, Straus SE and Arvin AM, Varicella-zoster virus replication,pathogenesis, and management. In: Knipe DM, Howley PM (eds.), Fieldsvirology, 5th ed., Philadelphia, Pa, Lippincott Williams & Wilkins, 2007,pp. 2773-818.
Hayward AR and Herberger M, Lymphocyte responses to varicellazoster virus in the elderly, J Clin Immunol 1987; 7:174-8.
Gnann, Jr. JW, Varicella zoster virus: atypical presentations and unusualcomplications, J Infect Dis 2002; 186: S91-8.
National Institute for Health and Clinical Excellence (nice), cks clinicalknowledge summaries, Shingles. Available in: www.cks.nice.org.uk. AccessedMar 2014.
Dworkin RH, Johnson RW, Breuer J et al., Recommendations for themanagement of herpes zoster, Clin Infect Dis 2007; 44:S1-26.
Chen N, Li Q, Yang J et al., Antiviral treatment for preventing postherpeticneuralgia, Cochrane Database Syst Rev 2014; 2:cd006866.
Dworkin RH, Johnson RW, Breuer J et al., Recommendations for themanagement of herpes zoster, Clin Infect Dis 2007; 44:Suppl 1: S1.
Wood MJ, Kay R, Dworkin RH et al., Oral acyclovir therapy acceleratespain resolution in patients with herpes zoster: a meta-analysis ofplacebo-controlled trials, Clin Infect Dis 1996; 22:341.
Jackson JL, Gibbons R, Meyer G and Inouye L, The effect of treatingherpes zoster with oral acyclovir in preventing postherpetic neuralgia.A meta-analysis, Arch Intern Med 1997; 157:909.
Tyring S, Barbarash RA, Nahlik JE et al., Famciclovir for the treatmentof acute herpes zoster: effects on acute disease and postherpeticneuralgia. A randomized, double-blind, placebo-controlled trial. CollaborativeFamciclovir Herpes Zoster Study Group, Ann Intern Med
1995; 123:89.19. Gnann JW Jr, New antivirals with activity against varicella-zoster virus,Ann Neurol 1994; 35 Suppl:S69.
Beutner KR, Friedman DJ, Forszpaniak C et al., Valaciclovir comparedwith acyclovir for improved therapy for herpes zoster in immunocompetentadults, Antimicrob Agents Chemother 1995; 39:1546.
Salvaggio MR and Gnann JW Jr, Drugs for herpesvirus infections ininfectious diseases, 4th ed., 2017.
Yaldiz M, Solak B, Kara RO, Cosansu N and Erdem MT, Comparisonof famciclovir, valaciclovir, and brivudine treatments in adult immunocompetentpatients with herpes zoster, American Journal of Therapeutics2018; 25(6):e626-34.