2022, Number 2
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Rev Nefrol Dial Traspl 2022; 42 (2)
Membranous paraneoplastic nephropathy due to solitary pulmonary nodule in a young patient
Di Bernardo G, Ramírez PL, Aquino AÁ, Palma DA
Language: Spanish
References: 12
Page: 144-148
PDF size: 345.36 Kb.
ABSTRACT
A solitary pulmonary nodule is
defined as a rounded opacity that can
measure up to 3 cm and is surrounded
by healthy lung parenchyma. Its
prevalence ranges from 2-24% in
the non-investigated population and
most of these have a benign course,
requiring a differential diagnosis with
neoplasms, infections, congenital and
vascular origins. The relationship
between oncological pathologies and
renal manifestations in the form of
paraneoplastic syndromes has been
widely described in the literature
since its first reports almost 100
years ago. Among the paraneoplastic
glomerulopathies, membranous
nephropathy is the one most associated
with the development of solid tumors
among those most frequently described
in the lung, gastrointestinal tract, and
prostate. It is suggested that its origin
is based on the response generated by
the products formed from tumor cells.
The case of a patient with a diagnosis
of solitary pulmonary nodule who
develops nephrotic syndrome is
presented, confirming the presence
of membranous nephropathy by renal
biopsy. Due to presenting a positive
anti PLA2R and the cause not being
found in complementary studies,
surgical extraction of the solitary
pulmonary nodule was performed
with which the remission of the
condition was achieved.
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