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ISSN 2448-8909 (Print)

2022, Number 6

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Med Crit 2022; 36 (6)

Association of mechanical power and ventilatory intensity with mortality in patients with severe COVID-19

Hernández PJC, Pinedo LM

Language: Spanish
References: 17
Page: 357-362
PDF size: 214.31 Kb.


ABSTRACT

Introduction: mechanical power (MP) and ventilatory intensity (VI) has been associated with ventilator induced lung injury (VILI). Objective: to evaluate the association between mechanical power and ventilatory intensity with mortality in severe covid-19 patients. Material and methods: observational, cohort, retrospective study conducted in patients with severe COVID-19. Results: 56 patients of mean age 57.9 ± 11.7 years (46.4% female/53.6% male) were included. The VI was not different between deceased and survivors, but it was significantly higher in the deceased between MP. Overall mortality was 60.7%, in patients with a MP > 15 J/min it was 91.7% and in those with a MP < 15 J/min on the first day it was 52.3% (p = 0.018). The RR for mortality of a MP > 15 J/min was 10.0 (95% CI 1.2-84.6). In the multivariate analysis, MP continued to be independently and significantly associated with mortality. The CUA of the MP to predict mortality was 0.627 of the VI it was 0.527 of the APACHE score it was 0.721 and of a combined model of MP + APACHE-II it was 0.774. Conclusions: a MW> 15 J/min was significantly associated with higher mortality in patients with severe COVID-19 and, in combination with the APACHE II score at admission, improves its predictive capacity.


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