medigraphic.com
ISSN 1561-297X (Print)

2021, Number 2

<< Back Next >>

Rev Cubana Estomatol 2021; 58 (2)

Association between CD4 T lymphocyte levels and oral lesions in HIV/AIDS patients

Turriate VC, Rodríguez FA, Castro-Rodríguez

Language: Spanish
References: 25
Page:
PDF size: 586.10 Kb.


ABSTRACT

Introduction: Oral diseases may be aggravated in HIV/AIDS patients depending on their immune response and lymphocyte levels.
Objective: Describe the relationship between CD4 T lymphocyte levels and the main oral lesions in HIV/AIDS patients from Hipólito Unanue National Hospital in Lima, Peru, during the year 2018.
Methods: An analytical cross-sectional study was conducted of 65 hospitalized patients from July to October 2018. The patients underwent oral clinical examination. Evaluation was performed of the presence of HIV/AIDS-related oral manifestations, and CD4 T lymphocyte levels were classified into three categories: > 500 cell/mm3, 200-500 cell/mm3 and < 200 cell/lmm3.
Results: Of the total patients studied, 70.8% were not under antiretroviral treatment at the moment of the examination. Average CD4 T lymphocyte level was 237.65 cell/mm3, with higher results among women. 56.9% of the patients had oral lesions. Males were more commonly affected (91%). The most frequent lesion type was oral candidiasis (44.6%), whereas the category presenting the highest frequency of oral lesions was < 200 cell/mm3 (38.5%; p < 0.05).
Conclusions: Male patients presented the largest number of oral lesions associated to low CD4 T lymphocyte levels. Most of the oral lesions were found at a CD4 T lymphocyte level < 200 cell/mm3. Oral candidiasis was the lesion most commonly found by the clinical examination.


REFERENCES

  1. Lahoti S, Rao K, Umadevi HS, Mishra L. Correlation of mucocutaneous manifestations of HIV-infected patients in an ART center with CD4 counts. Indian J Dent Res. 2017;28(5):549-54. PMID: 29072219

  2. Ratnam M, Nayyar AS, Reddy DS, Ruparani B, Chalapathi KV, Azmi SM. CD4 cell counts and bucal manifestations in HIV infected and AIDS patients. J Bucal Maxillofac Pathol. 2018;22(2):282. PMID: 30158790

  3. Frimpong P, Amponsah EK, Abebrese J, Kim SM. Bucal manifestations and their correlation to baseline CD4 count of HIV/AIDS patients in Ghana. J Korean Assoc Bucal Maxillofac Surg. 2017;43(1):29-36. PMID: 28280707

  4. Berberi A, Noujeim Z. Epidemiology and Relationships between CD4+ Counts and Bucal Lesions among 50 Patients Infected with Human Immunodeficiency Virus. J Int Bucal Health. 2015;7(1):18-21. PMID: 25709361

  5. Lu CL, Pai JA, Nogueira L, Mendoza P, Gruell H, Oliveira TY, et al. Relationship between intact HIV-1 proviruses in circulating CD4+ T cells and rebound viruses emerging during treatment interruption. Proc Natl Acad Sci (EE. UU.). 2018;115(48):E11341-8. PMID: 30420517

  6. Berberi A, Aoun G. Bucal lesions associated with human immunodeficiency virus in 75 adult patients: a clinical study. J Korean Assoc Bucal Maxillofac Surg . 2017;43(6):388-94. PMID: 29333368

  7. Chandrakala C, Parimalam K, Wahab AJ, Anand N. Correlating CD4 count with mucocutaneous manifestations in HIV-positive patients: A prospective study. Indian J Sex Transm Dis AIDS. 2017;38(2):128-135. PMID: 30148265

  8. Satyakiran GV, Bavle RM, Alexander G, Rao S, Venugopal R, Hosthor SS. A relationship between CD4 count and bucal manifestations of human immunodeficiency virus-infected patients on highly active antiretroviral therapy in urban population. J Bucal Maxillofac Pathol . 2016;20(3):419-26. PMID: 27721607

  9. Tappuni AR, Flemming GJ. The effect of antiretroviral therapy on the prevalence of bucal manifestations in HIV-infected patients: a UK study. Bucal Surg Bucal Med Bucal Pathology Bucal Radio Endodontics. 2001[acceso: 06/11/2019]; 92(6):623-8. Disponible en: Disponible en: https://linkinghub.elsevier.com/retrieve/pii/S1079-2104(01)75952-5

  10. Taylor BS, Tieu HV, Jones J, Wilkin TJ. CROI 2019: advances in antiretroviral therapy. Top Antivir Med. 2019;27(1):50-68. PMID: 31137003

  11. Gallardo R, Castillo K, Alegría P, Blackburn E. Manifestaciones Bucales en pacientes VIH/sida del Hospital Base de Valdivia en Chile. Rev CES Odont. 2016 [acceso: 16/12/2019]; 29(2):12-9. Disponible en: Disponible en: http://www.scielo.org.co/scielo.php?pid=S0120-971X2016000200003&script=sci_abstract&tlng=en

  12. World Medical Association. World Medical Association Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects. JAMA. 2013;27;310(20):2191-4. PMID: 24141714

  13. Shiboski CH, Patton L, Webster-Cyriaque JY, Greenspan D, Traboulsi R, Ghannoum M. The Bucal HIV/AIDS Research Alliance: updated case definitions of bucal disease endpoints. J Bucal Pathol Med. 2009 [acceso: 16/12/2019]; 38:481-8. Disponible en: Disponible en: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0714.2009.00749.x

  14. Classification and diagnostic criteria for bucal lesions in HIV infection. EC-Clearinghouse on Bucal Problems Related to HIV Infection and WHO Collaborating Centre on Bucal Manifestations of the Immunodeficiency Virus. J Bucal Pathol Med . 1993;22:289-91. PMID: 8229864

  15. Saavedra A. Manifestaciones clínicas bucales en pacientes VIH/sida en el servicio de infectología Hospital Nacional Hipólito Unanue en el año 2014 [ Tesis de bachiller]. Lima: Universidad Nacional Mayor de San Marcos; 2016. [acceso: 16/12/2019]. Disponible en: Disponible en: http://cybertesis.unmsm.edu.pe/handle/cybertesis/4908

  16. Taivo D. Manifestaciones bucomaxilofaciales en pacientes adultos VIH/sida del Hospital San Juan de Dios y su relación con recuento de linfocitos TCD4+ y carga viral [Tesis de bachiller]. Santiago de Chile: Universidad de Chile, Departamento de Cirugía y Traumatología Maxilofacial; 2015. [acceso: 16/12/2019]. Disponible en: Disponible en: http://repositorio.uchile.cl/handle/2250/141563

  17. Donoso-Hofer F. Oral lesions associated with human immunodeficiency virus disease in adult patients, a clinical perspective. Rev Chilena Infectol. 2016;33(Suppl 1):27-35. PMID: 28453025

  18. Harris J, Herrera A. Candidiasis bucal en pacientes VIH/sida asociada a niveles de linfocitos T CD4 y terapia antirretroviral. Rev Cubana Estomatol. 2016 [acceso: 16/12/2019]; 53(1):9-14. Disponible en: Disponible en: http://www.revestomatologia.sld.cu/index.php/est/article/view/785/246

  19. Vohra P, Jamatia K, Subhada B, Vinay R, Tiwari C, Nabeel MS, et al. Correlation of CD4 counts with oral and systemic manifestations in HIV patients. J Family Med Prim Care. 2019;8(10):3247-52. PMCID: PMC6857402

  20. Frimpong P, Kofi EA, Abebrese J, Min SK. Oral manifestations and their correlation to baseline CD4 count of HIV/AIDS patients in Ghana. J Korean Assoc Oral Maxillofac Surg. 2017;43(1):29-36. PMCID: PMC5342969

  21. Ramírez V, Esquivel L, Sierra J, Anaya G, González I. The Changing Clinical Spectrum of Human Immunodeficiency Virus (HIV) related Bucal Lesions in 1,000 Consecutive Patients: A 12-Year Study in a referral Center in Mexico. Medicine (Baltimore). 2003 [acceso: 12/01/2020]; 82(1):39-50. Disponible en: Disponible en: https://insights.ovid.com/crossref?an=00005792-200301000-00004

  22. Donoso F. Lesiones bucales asociadas con la enfermedad del virus de inmunodeficiencia humana en pacientes adultos, una perspectiva clínica. Rev Chilena Infectol . 2016 [acceso: 12/01/2020]; 33(1):27-35. Disponible en: Disponible en: https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-10182016000700004

  23. Pakfetrat A, Falaki F, Delavarian Z, Dalirsani Z, Sanatkhani, Marani M. Bucal Manifestations of Human Immunodeficiency Virus-Infected Patients. Iran J Otorhinolaryngol. 2015;27(1):78. PMID: 25745611

  24. Medina NE, Brett MM, Betancourt FA, Patiño JC. Frecuencia de lesiones en cavidad bucal de pacientes con VIH/sida en el Hospital Universitario San Ignacio de Bogotá, Colombia. Univ Odontol. 2012 [acceso: 12/01/2020]; 31(66):51-8. Disponible en: Disponible en: https://revistas.javeriana.edu.co/index.php/revUnivOdontologica/article/view/2713

  25. Bravo M, Correnti M, Escalona L, Perrone M, Brito A, Tovar V, et al. Prevalence of bucal lesions in HIV patients related to CD4 cell count and viral load in a Venezuelan population. Med Bucal Patol Bucal Cir Bucal. 2006 [acceso: 12/01/2020]; 11:33-9. Disponible en: Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1698-69462006000100008




2020     |     www.medigraphic.com