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2001, Number S1

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Arch Cardiol Mex 2001; 71 (S1)

Angiogenesis

Peña DMA

Language: Spanish
References: 12
Page: 136-138
PDF size: 33.06 Kb.


ABSTRACT

Angiogenesis refers to a process of new vessel formation originated from pre-existent vessels. This mechanisms requires a series of complex events that include pro-angiogenic and antiangiogenic molecules. Among the angiogenic factors studied are the fibroblast growth factor (FGF) and the vascular endothelial growth factor (VEGF). Recently, great efforts have been made to apply these factors to the treatment of advanced and chronic ischemic heart disease and for peripheral arterial disease. The present paper reviews angiogenic mechanisms as well as experimental and clinical studies reported in the literature.


REFERENCES

  1. ENGLER D: Angiogenesis. Circulation 1996; 94: 1496-1498.

  2. SELKE FW, JIANYI L, STAMLER A: Angiogenesis induced by acidic fibroblast growth factor as an alternative method of revascularization for chronic myocardial ischemia. Surgery 1996; 120: 182-188.

  3. ASAHARA T, BAUTERS C, ZHENG LP: Synergistic effect of vascular endothelial growth factor and basic fibroblast growth factor on angiogenesis in vivo. Circulation 1995; 92: II- 365-II-371.

  4. FOLKMAN J, SHING Y: Angiogenesis. J Biol Chem 1992; 267: 1031-1034.

  5. TAKESHITA S, ZHENG LP, BROGI E, KEARNEY M, ET AL: Therapeutic angiogenesis a single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model. J Clin Invest 1994; 93: 662-670.

  6. BANAI S, JAKLITSCH MT, SCHOU M, LAZAROUS DF, ET AL: Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor in dogs. Circulation 1994; 89: 2183- 2189.

  7. FOLKMAN J: Angiogenic therapy of the human heart. Circulation 1998; 97: 628-629.

  8. KORNOWSKI R, FUCHS S, LEON M, EPSTEIN S: Delivery strategies to achive therapeutic myocardial angiogenesis. Circulation 2000; 101: 454-458.

  9. HENRY TD, ANNEX BH, AZRIN MA, MCKENDALL GR, WILLERSON JT, ET AL: Double blind, placebo, controlled trial of recombinant human vascular endothelial growth factor: the VIVA trial. J Am Coll Cardiol 1999; 33(suppl A): 384A. Abstract.

  10. SCHUMACHER B, PECHER P, VON SPECHT BU, STEGMAN T: Induction of neoangiogenesis in ischemic myocardium by human growth factor: first clinical results of new treatment, of coronary heart disease. Circulation 1998; 97: 645-650.

  11. KORNOWSKI R, FUCHS S, VODOVOTZ Y, GORDON D, FLYNN M, KOVESDI I, LEON MB, ET AL: Successful gene transfer in a porcine ischemia model using the biosense guided transendocardial injection catheter. J Am Coll Cardiol 1999; 33(suppl A): 355A. Abstract.

  12. BAUMGARTNER I, PIECZEK A, MANOR O, BLAIR R, KEARNEY M, WALSH K, ISNER JI: Constitutive expression of ph VEGF 165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia. Circulation 1998; 97: 1114- 1123.




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