2022, Number 1
<< Back Next >>
Medicina & Laboratorio 2022; 26 (1)
Disseminated cryptococcosis in an immunocompetent patient imitating metastatic lung cancer
Peinado-Acevedo JS, Cáceres-Galvis C, Cardona-Palacio A, Arango-Viana JC, Roldán-Pérez M, Atencia-Flórez C
Language: Spanish
References: 27
Page: 81-89
PDF size: 417.59 Kb.
ABSTRACT
Lung cancer is the leading cause of death from cancer in the world and
the second in Colombia, its prognosis is bad when the diagnosis of metastatic disease
in the central nervous system is documented. The diagnosis is based on the
definitive pathologic result. Although the imaging findings can be highly suggestive
of malignancy, there are reports of other conditions that can mimic lung cancer,
such as infections or benign tumors, which can lead to inappropriate treatment.
Fungal infections such as those caused by Criptococcus neoformans are capable
of generating lesions that can mimic neoplasms. The objective of this article is to
report the case of a man who was initially diagnosed with metastatic lung carcinoma
to the central nervous system, and was finally diagnosed with disseminated
cryptococcosis after his death.
REFERENCES
Pardo C, De Vries E, Buitrago L, Gamboa Ó.Atlas de mortalidad por cáncer en Colombia.4ta ed. Bogotá D.C.: Instituto Nacional de CancerologíaESE; 2017. p. 120.
Ali A, Goffin JR, Arnold A, Ellis PM. Survivalof patients with non-small-cell lung cancer aftera diagnosis of brain metastases. Curr Oncol2013;20:e300-306. https://doi.org/10.3747/co.20.1481.
Rolston KV, Rodriguez S, Dholakia N, WhimbeyE, Raad I. Pulmonary infections mimickingcancer: a retrospective, three-year review. SupportCare Cancer 1997;5:90-93. https://doi.org/10.1007/bf01262563.
Homrich GK, Andrade CF, Marchiori RC, LidtkeGdos S, Martins FP, Santos JW. Prevalenceof benign diseases mimicking lung cancer: experiencefrom a university hospital of southernBrazil. Tuberc Respir Dis (Seoul) 2015;78:72-77.https://doi.org/10.4046/trd.2015.78.2.72.
Furuya K, Yasumori K, Takeo S, Sakino I,Uesugi N, Momosaki S, et al. Lung CT: Part1, Mimickers of lung cancer--spectrum of CTfindings with pathologic correlation. AJR Am JRoentgenol 2012;199:W454-463. https://doi.org/10.2214/ajr.10.7262.
Gazzoni FF, Severo LC, Marchiori E, Irion KL,Guimarães MD, Godoy MC, et al. Fungal diseasesmimicking primary lung cancer: radiologicpathologiccorrelation. Mycoses 2014;57:197-208. https://doi.org/10.1111/myc.12150.
Nsenga L, Kajjimu J, Olum R, NinsiimaS, Kyazze AP, Ssekamatte P, et al. Cryptococcosiscomplicating diabetes mellitus:a scoping review. Ther Adv Infect Dis2021;8:20499361211014769. https://doi.org/10.1177/20499361211014769.
Gushiken AC, Saharia KK, Baddley JW. Cryptococcosis.Infect Dis Clin North Am 2021;35:493-514. https://doi.org/10.1016/j.idc.2021.03.012.
Bennett JE, Dolin R, Blaser MJ. Mandell, Douglas,and Bennett’s Principles and Practice ofInfectious Diseases. 9th ed. Ámsterdam, PaísesBajos: Elsevier; 2020. p. 4176.
MacDougall L, Fyfe M, Romney M, Starr M,Galanis E. Risk factors for Cryptococcus gattii infection,British Columbia, Canada. Emerg InfectDis 2011;17:193-199. https://doi.org/10.3201/eid1702.101020.
Li SS, Mody CH. Cryptococcus. Proc Am ThoracSoc 2010;7:186-196. https://doi.org/10.1513/pats.200907-063AL.
Colom-Valiente MF, Abarca-Salat ML, Arechavala-Silva A, Arévalo-Morales MP, Calderón-Sandubete EJ, Torres-Rodríguez JM. Capítulo7 – Criptococosis y otras micosis causadas porlevaduras. In: Quindós G, ed. Micología Clínica.Ámsterdam, Países Bajos: Elsevier; 2015. p. 109-128.
Skolnik K, Huston S, Mody CH. Cryptococcallung infections. Clin Chest Med2017;38:451-464. https://doi.org/10.1016/j.ccm.2017.04.007.
Perfect JR, Bicanic T. Cryptococcosis diagnosisand treatment: What do we know now.Fungal Genet Biol 2015;78:49-54. https://doi.org/10.1016/j.fgb.2014.10.003.
Gazzoni AF, Severo CB, Salles EF, SeveroLC. Histopathology, serology and cultures inthe diagnosis of cryptococcosis. Rev Inst MedTrop Sao Paulo 2009;51:255-259. https://doi.org/10.1590/s0036-46652009000500004.
Bonifaz-Trujillo JA. Criptococosis. Micologíamédica básica. 5 ed. New York: McGraw-HillEducation; 2015.
Roebuck DJ, Fisher DA, Currie BJ. Cryptococcosisin HIV negative patients: findings on chestradiography. Thorax 1998;53:554-557. https://doi.org/10.1136/thx.53.7.554.
Song KD, Lee KS, Chung MP, Kwon OJ, KimTS, Yi CA, et al. Pulmonary cryptococcosis:imaging findings in 23 non-AIDS patients. KoreanJ Radiol 2010;11:407-416. https://doi.org/10.3348/kjr.2010.11.4.407.
Mitchell DH, Sorrell TC, Allworth AM, HeathCH, McGregor AR, Papanaoum K, et al. Cryptococcaldisease of the CNS in immunocompetenthosts: influence of cryptococcal variety onclinical manifestations and outcome. Clin InfectDis 1995;20:611-616. https://doi.org/10.1093/clinids/20.3.611.
Mitchell DH, Sorrell TC. Pancoast's syndromedue to pulmonary infection with Cryptococcusneoformans variety gattii. Clin Infect Dis1992;14:1142-1144. https://doi.org/10.1093/clinids/14.5.1142.
Escandón P, de Bedout C, Lizarazo J, AgudeloCI, Tobón Á, Bello S, et al. Cryptococcosis inColombia: Results of the national surveillanceprogram for the years 2006-2010. Biomédica2012;32:386-398.
Polacheck I, Platt Y, Aronovitch J. Catecholaminesand virulence of Cryptococcusneoformans. Infect Immun 1990;58:2919-2922. https://doi.org/10.1128/iai.58.9.2919-2922.1990.
Chen SC, Slavin MA, Heath CH, Playford EG,Byth K, Marriott D, et al. Clinical manifestationsof Cryptococcus gattii infection: determinantsof neurological sequelae and death.Clin Infect Dis 2012;55:789-798. https://doi.org/10.1093/cid/cis529.
Chen S, Sorrell T, Nimmo G, Speed B, CurrieB, Ellis D, et al. Epidemiology and host- andvariety-dependent characteristics of infectiondue to Cryptococcus neoformans in Australiaand New Zealand. Australasian CryptococcalStudy Group. Clin Infect Dis 2000;31:499-508.https://doi.org/10.1086/313992.
Lizarazo J, Escandón P, Agudelo CI, FiracativeC, Meyer W, Castañeda E. Retrospectivestudy of the epidemiology and clinical manifestationsof Cryptococcus gattii infections inColombia from 1997-2011. PLoS Negl Trop Dis2014;8:e3272. https://doi.org/10.1371/journal.pntd.0003272.
Boulware DR, Rolfes MA, Rajasingham R,von Hohenberg M, Qin Z, Taseera K, et al.Multisite validation of cryptococcal antigen lateralflow assay and quantification by laser thermalcontrast. Emerg Infect Dis 2014;20:45-53.https://doi.org/10.3201/eid2001.130906.
Liesman RM, Strasburg AP, Heitman AK, TheelES, Patel R, Binnicker MJ. Evaluation of acommercial multiplex molecular panel for diagnosisof infectious meningitis and encephalitis.J Clin Microbiol 2018;56: e01927-17. https://doi.org/10.1128/jcm.01927-17.