2022, Number 2
<< Back
Acta de Otorrinolaringología CCC 2022; 50 (2)
Descending mediastinitis in the context of Ludwig’s Angina. Article review
Fuentes FAL, Romero MLF, Olivera AMP, Cortés LJA, Ulloque AHA
Language: Spanish
References: 50
Page: 151-158
PDF size: 185.13 Kb.
ABSTRACT
Introduction: Mediastinitis is defined as the usually infectious inflammatory process
of the mediastinal connective tissue and the organs it surrounds. Specifically,
descending mediastinitis corresponds to a rare complication, an infection of deep
spaces of the neck, oropharynx, or oral cavity, which extends through the facial
spaces of the neck, dissecting. Less frequent, this pathology can originate from
parotiditis, skin infections of the neck or epiglottitis. Also, less frequent it can be
generated in the context of trauma to the neck or oral cavity. This study intends to
draw attention to the aspects that involve the ENT specialist in the management
of patients with deep neck infections and their role in the diagnosis and effective
treatment of descending mediastinitis as the main cause of mortality in these
patients.
Methodology: A search was carried out with the keywords “Airway”
“Ludwig’s angina” in PubMed, no filtering was performed by date or type of study,
finding a total of 147 articles, abstracts were read by the authors, selecting
50. A critical reading of the 50 articles full texts is carried out and the relevant
information is extracted.
Conclusion: This pathology of marked severity, carries a
significant increase in mortality and its treatment, although it remains controversial
in certain circumstances, it must be aggressive and timely, focusing the role
of the otorhinolaryngologist on 4 pillars of treatment: surgical drainage, antibiotic
therapy, hemodynamic support, and airway safety.
REFERENCES
Diamantis S, Giannakopoulos H, Chou J, Foote J. Descendingnecrotizing mediastinitis as a complication of odontogenicinfection. Int J Surg Case Rep. 2011;2(5):65-7. doi: 10.1016/j.ijscr.2011.01.004.
Pearse HE. Mediastinitis following cervical suppuration.Ann Surg. 1938;108(4):588-611. doi: 10.1097/00000658-193810000-00009.
Akulian JA, Yarmus L, Feller-Kopman D. The role ofcricothyrotomy, tracheostomy, and percutaneous tracheostomyin airway management. Anesthesiol Clin. 2015;33(2):357-67.doi: 10.1016/j.anclin.2015.02.009.
Estrera AS, Landay MJ, Grisham JM, Sinn DP, Platt MR.Descending necrotizing mediastinitis. Surg Gynecol Obstet.1983;157(6):545-52.
Ueda S, Nishio K, Minamino N, Kubo A, Akai Y, KangawaK, et al. Increased plasma levels of adrenomedullin inpatients with systemic inflammatory response syndrome. AmJ Respir Crit Care Med. 1999;160(1):132-6. doi: 10.1164/ajrccm.160.1.9810006.
Parhiscar A, Har-El G. Deep neck abscess: A retrospective reviewof 210 cases. Ann Otol Rhinol Laryngol. 2001;110(11):1051-4.doi: 10.1177/000348940111001111.
Deu-Martín M, Saez-Barba M, López Sanz I, AlcarazPeñarrocha R, Romero Vielva L, Solé Montserrat J. Factores deriesgo de mortalidad en la mediastinitis necrosante descendente[Mortality risk factors in descending necrotizing mediastinitis].Arch Bronconeumol. 2010;46(4):182-7. doi: 10.1016/j.arbres.2010.01.008.
Abu Abeeleh M, Al Smady M, Qasem H, Ennab R, Al BsoulN. Descending necrotising mediastinitis, a fatal disease to keepin mind. Heart Lung Circ. 2010;19(4):254-6. doi: 10.1016/j.hlc.2009.11.010.
Crespo AN, Chone CT, Fonseca AS, Montenegro MC,Pereira R, Milani JA. Clinical versus computed tomographyevaluation in the diagnosis and management of deep neckinfection. Sao Paulo Med J. 2004;122:259-63. doi: S1516-31802004000600006.
Hasegawa T, Endo S, Sohara Y. Classification of descendingnecrotizing mediastinitis. Ann Thorac Surg. 2000;69(4):1296.doi: 10.1016/s0003-4975(00)01117-6.
Lindner HH. The anatomy of the fasciae of the face and neckwith particular reference to the spread and treatment of intraoralinfections (Ludwig’s) that have progressed into adjacent fascialspaces. Ann Surg. 1986;204(6):705-14. doi: 10.1097/00000658-198612000-00015.
Guidera AK, Dawes PJ, Fong A, Stringer MD. Head and neckfascia and compartments: No space for spaces. Head Neck.2014;36(7):1058-68. doi: 10.1002/hed.23442.
Kitamura S. Anatomy of the fasciae and fascial spaces ofthe maxillofacial and the anterior neck regions. Anat Sci Int.2018;93(1):1-13. doi: 10.1007/s12565-017-0394-x.
Standring S. Head and neck. En: Standring S, Borley NR,Cllins P, et al (editores). Gray’s anatomy: The anatomicalbasis of clinical practice. 40ª edición. Philadelphia: ChurchillLivingstone Elsevier. 2000. p. 397-703.
Shah RK, Chun R, Choi SS. Mediastinitis in infants fromdeep neck space infections. Otolaryngology Head Neck Surg.2009;140:936-8. doi: 10.1016/j.otohns.2009.02.032.
Stambuk HE, Patel SG. Imaging of the parapharyngeal space.Otolaryngol Clin North Am. 2008;41(1):77-101. doi: 10.1016/j.otc.2007.10.012.
Cruz Toro P, Callejo Castillo À, Tornero Saltó J, GonzálezCompta X, Farré A, Maños M. Cervical necrotizingfasciitis: Report of 6 cases and review of literature. Eur AnnOtorhinolaryngol Head Neck Dis. 2014;131(6):357-9. doi:10.1016/j.anorl.2013.08.006.
Mark R, Song S, Mark P. Taking heed of the ‘danger space’:acute descending necrotising mediastinitis secondary toprimary odontogenic infection. BMJ Case Rep. 2018;bcr-2018-225019. doi: 10.1136/bcr-2018-225019.
Sakamoto H, Aoki T, Kise Y, Watanabe D, Sasaki J. Descendingnecrotizing mediastinitis due to odontogenic infections. OralSurg Oral Med Oral Pathol Oral Radiol Endod. 2000;89(4):412-9. doi: 10.1016/s1079-2104(00)70121-1.
Argintaru N, Carr D. Retropharyngeal abscess: A subtlepresentation of a deep space neck infection. J Emerg Med.2017;53(4):568-569. doi: 10.1016/j.jemermed.2017.06.004.
Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H,Opal SM, et al. Surviving sepsis campaign: Internationalguidelines for management of severe sepsis and septic shock:2012. Crit Care Med. 2013;41(2):580-637. doi: 10.1097/CCM.0b013e31827e83af.
Poveda Roda R, Bagan JV, Sanchis Bielsa JM, Carbonell PastorE. Antibiotic use in dental practice. A review. Med Oral PatolOral Cir Bucal. 2007;12(3):E186-92.
Storoe W, Haug RH, Lillich TT. The changing face ofodontogenic infections. J Oral Maxillofac Surg. 2001;59(7):739-48. doi: 10.1053/joms.2001.24285.
Velasco I, Soto R. Principles for the treatment of odontogenicinfections with different levels of complexity. Rev Chil Cir.2012;64:586-98. doi: 10.4067/S0718-40262012000600016.
Singer M, Deutschman CS, Seymour CW, Shankar-Hari M,Annane D, Bauer M, et al. The Third International Consensusdefinitions for sepsis and septic shock (sepsis-3). JAMA.2016;315(8):801-10. doi: 10.1001/jama.2016.0287.
Vural C, Gungor A, Comerci S. Accuracy of computerizedtomography in deep neck infections in the pediatric population.Am J Otolaryngol. 2003;24(3):143-8. doi: 10.1016/s0196-0709(03)00008-5.
Levitt GW. Cervical fascia and deep neck infections.Laryngoscope. 1970;80(3):409-35. doi: 10.1288/00005537-197003000-00004.
Daramola OO, Flanagan CE, Maisel RH, Odland RM.Diagnosis and treatment of deep neck space abscesses.Otolaryngol Head Neck Surg. 2009;141(1):123-30. doi:10.1016/j.otohns.2009.03.033.
Kang SK, Lee S, Oh HK, Kang MW, Na MH, Yu JH, et al.Clinical features of deep neck infections and predisposingfactors for mediastinal extension. Korean J Thorac CardiovascSurg. 2012;45(3):171-6. doi: 10.5090/kjtcs.2012.45.3.171.
Roccia F, Pecorari GC, Oliaro A, Passet E, Rossi P, NadalinJ, et al. Ten years of descending necrotizing mediastinitis:Management of 23 cases. J Oral Maxillofac Surg.2007;65(9):1716-24. doi: 10.1016/j.joms.2006.10.060.
Bhatt YM, Small M. Cervical necrotising fasciitis withdescending necrotising mediastinitis. Postgrad Med J.2011;87(1030):570. doi: 10.1136/pgmj.2010.117010.
Sandner A, Börgermann J, Kösling S, Bloching MB.“Descending necrotizing mediastinitis” infolge tieferHalsinfektionen. Inzidenz und Management [“Descendingnecrotizing mediastinitis” due to deep neck infections.Incidence and management]. HNO. 2006;54(11):861-7. doi:10.1007/s00106-006-1396-5.
Makeieff M, Gresillon N, Berthet JP, Garrel R, Crampette L,Marty-Ane C, et al. Management of descending necrotizingmediastinitis. Laryngoscope. 2004;114(4):772-5. doi:10.1097/00005537-200404000-00035.
Busch RF, Shah D. Ludwig’s angina: improved treatment.Otolaryngol Head Neck Surg. 1997;117(6):S172-5. doi:10.1016/S0194-59989770093-7.
Jones AE, Trzeciak S, Kline JA. The sequential organ failureassessment score for predicting outcome in patients with severesepsis and evidence of hypoperfusion at the time of emergencydepartment presentation. Crit Care Med. 2009;37(5):1649-54.doi: 10.1097/CCM.0b013e31819def97.
Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, KnoblichB, et al. Early goal-directed therapy in the treatment of severesepsis and septic shock. N Engl J Med. 2001;345(19):1368-77.doi: 10.1056/NEJMoa010307.
Ovassapian A, Tuncbilek M, Weitzel EK, Joshi CW. Airwaymanagement in adult patients with deep neck infections: a caseseries and review of the literature. Anesth Analg. 2005;100(2):585-9. doi: 10.1213/01.ANE.0000141526.32741.CF.
Sarna T, Sengupta T, Miloro M, Kolokythas A. Cervicalnecrotizing fasciitis with descending mediastinitis:Literature review and case report. J Oral Maxillofac Surg.2012;70(6):1342-50. doi: 10.1016/j.joms.2011.05.007.
Karkos PD, Leong SC, Beer H, Apostolidou MT, PanareseA. Challenging airways in deep neck space infections.Am J Otolaryngol. 2007;28:415e418. doi: 10.1016/j.amjoto.2006.10.012.
Poeschl PW, Spusta L, Russmueller G, Seemann R, Hirschl A,Poeschl E, et al. Antibiotic susceptibility and resistance of theodontogenic microbiological spectrum and its clinical impacton severe deep space head and neck infections. Oral Surg OralMed Oral Pathol Oral Radiol Endod 2010;110:151-6. doi:10.1016/j.tripleo.2009.12.039.
Hasegawa J, Hidaka H, Tateda M, Kudo T, Sagai S, MiyazakiM, et al. An analysis of clinical risk factors of deep neckinfection. Auris Nasus Larynx. 2011;38(1):101-7. doi:10.1016/j.anl.2010.06.001.
Eftekharian A, Roozbahany NA, Vaezeafshar R, Narimani N.Deep neck infections: A retrospective review of 112 cases.Eur Arch Otorhinolaryngol. 2009;266(2):273-7. doi: 10.1007/s00405-008-0734-5.
Osborn, T. Assael, R. Deep space neck infección: Principles ofsurgical management. Oral Maxillofac Surg Clinic North Am.2008;20:356-65. doi: 10.1016/j.coms.2008.04.002.
Gawrychowski J, Rokicki W, Rokicki M. Martwiczezstepujace zapalenie śródpiersia--przebieg i metody leczeniachirurgicznego [Descending necrotic mediastinitis--courseand methods of surgical treatment]. Pneumonol Alergol Pol.2003;71(1-2):17-23.
Wheatley MJ, Stirling MC, Kirsh MM, Gago O, Orringer MB.Descending necrotizing mediastinitis: transcervical drainageis not enough. Ann Thorac Surg. 1990;49(5):780-4. doi:10.1016/0003-4975(90)90022-x.
Larawin V, Naipao J, Dubey SP. Head and neck spaceinfections. Otolaryngol Head Neck Surg. 2006;135(6):889-93.doi: 10.1016/j.otohns.2006.07.007.
Lee YQ, Kanagalingam J. Deep neck abscesses: The Singaporeexperience. Eur Arch Otorhinolaryngol. 2011;268(4):609-14.doi: 10.1007/s00405-010-1387-8.
Santos Gorjón P, Blanco Pérez P, Morales Martín AC, Del Pozode Dios JC, Estévez Alonso S, Calle de la Cabanillas MI. Deepneck infection. Acta Otorrinolaringol Esp. 2012;63(1):31-41.doi: 10.1016/j.otorri.2011.06.002.
Wang LF, Kuo WR, Tsai SM, Huang KJ. Characterizations oflife-threatening deep cervical space infections: a review of onehundred ninety-six cases. Am J Otolaryngol. 2003;24(2):111-7.doi: 10.1053/ajot.2003.31.
Huang TT, Liu TC, Chen PR, Tseng FY, Yeh TH, Chen YS.Deep neck infection: Analysis of 185 cases. Head Neck.2004;26(10):854-60. doi: 10.1002/hed.20014.