2022, Number 1
<< Back
Rev Med UAS 2022; 12 (1)
Connexins and exosomes: two mechanisms of communication in tumor
Hernández-Aragón LG, Avelino-Cruz JE, Pacheco-Pérez CA, Galindo-Ramírez F
Language: Spanish
References: 33
Page: 70-80
PDF size: 562.53 Kb.
ABSTRACT
Understand mechanism of communication that tumoral cells employed could help improve therapies to combat different types of cancer. Connexins and exosomes are part of this mechanism, the first ones conform channels in cellular membrane and second ones are a vesicle extremely small. Both have enormous potential for cancer treatment and eradication.
REFERENCES
Stahl PD, Raposo G. Extracellular Vesicles: Exosomes and Microvesicles, Integrators of Homeostasis. Physiology (Bethesda). 2019;34(3):169-177.
AlMusawi S, Ahmed M, Nateri AS. Under-standing cell-cell communication and signal-ing in the colorectal cancer microenviron-ment. Clin Transl Med. 2021;11(2): e308.
GLOBOCAN (2021) Cancer today, disponi-ble en http://gco.iarc.fr/).
Instituto Nacional de Cáncer, NIH (2021), disponible en https://www.cancer.gov/espa-nol/cancer/naturaleza/que-es
Brown AL, Li M, Goncearenco A, Pan-chenko AR. Finding driver mutations in can-cer: Elucidating the role of background mu-tational processes. PLoS Comput Biol. 2019;15(4):e1006981.
Arneth B. Tumor Microenvironment. Medi-cina (Kaunas). 2019;56(1):15.
Cooper GM. The Cell: A Molecular Ap-proach. 2nd edition. Sunderland (MA): Sinauer Associates; 2000. The Develop-ment and Causes of Cancer. Available: https://www.ncbi.nlm.nih.gov/books/NBK9963/
Jing X, Yang F, Shao C, Wei K, Xie M, Shen H, Shu Y. Role of hypoxia in cancer therapy by regulating the tumor microenvironment. Mol Cancer. 2019;11,18(1):15
Hinshaw DC, Shevde LA. The Tumor Micro-environment Innately Modulates Cancer Progression. Cancer Res. 2019;79(18):4557-4566.
Denton AE, Roberts EW, Fearon DT. Stro-mal Cells in the Tumor Microenvironment. Adv Exp Med Biol. 2018; 1060:99-114.
Hui L, Chen Y. Tumor microenvironment: Sanctuary of the devil. Cancer Lett. 2015;368(1):7-13.
Brücher BL, Jamall IS. Cell-cell communica-tion in the tumor microenvironment, carcino-genesis, and anticancer treatment. Cell Phy-siol Biochem. 2014;34(2):213-243.
Beyer EC, Berthoud VM. Gap junction gene and protein families: Connexins, innexins, and pannexins. Biochim Biophys Acta Bio-membr. 2018;1860(1):5-8.
Nielsen MS, Axelsen LN, Sorgen PL, Verma V, Delmar M, Holstein-Rathlou NH. Gap junctions. Compr Physiol. 2012;2(3):1981-2035.
Harris AL. Connexin channel permeability to cytoplasmic molecules. Prog Biophys Mol Biol. 2007;94(1-2):120-143.
Kar R, Batra N, Riquelme MA, Jiang JX. Bi-ological role of connexin intercellular chan-nels and hemichannels. Arch Biochem Biop-hys. 2012;524(1):2-15.
Johnstone RM. Exosomes biological signifi-cance: A concise review. Blood Cells Mol Dis. 2006;36(2):315-321.
Zhang J, Li S, Li L, Li M, Guo C, Yao J, Mi S. Exosome and exosomal microRNA: traf-ficking, sorting, and function. Genomics Pro-teomics Bioinformatics. 2015;13(1):17-24
Zhang L, Yu D. Exosomes in cancer devel-opment, metastasis, and immunity. Biochim Biophys Acta Rev Cancer. 2019;1871(2):455-468.
Zhang Y, Liu Y, Liu H, Tang WH. Exosomes: biogenesis, biologic function and clinical po-tential. Cell Biosci. 2019; 9:19.
Mollaei, H, Safaralizadeh R. Pouladi N. A brief review of exosomes and their roles in cáncer”. Meta Gene. 2017;11: 70–74.
Kahlert C, Kalluri R. Exosomes in tumor mi-croenvironment influence cancer progres-sion and metastasis. J Mol Med (Berl). 2013;91(4):431-437.
Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science. 2020;367(6478):eaau6977.
Colombo M, Raposo G, Théry C. Biogene-sis, secretion, and intercellular interactions of exosomes and other extracellular vesi-cles. Annu Rev Cell Dev Biol. 2014; 30:255-289.
Sánchez OF, Rodríguez AV, Velasco-Es-paña JM, Murillo LC, Sutachan JJ, Albarra-cin SL. Role of Connexins 30, 36, and 43 in Brain Tumors, Neurodegenerative Dis-eases, and Neuroprotection. Cells. 2020;9(4):846.
Uzu M, Sin WC, Shimizu A, Sato H. Conflict-ing Roles of Connexin43 in Tumor Invasion and Growth in the Central Nervous System. Int J Mol Sci. 2018;19(4):1159.
Sin WC, Crespin S, Mesnil M. Opposing roles of connexin43 in glioma progression. Biochim Biophys Acta. 2012;1818(8):2058-2067.
Kameritsch P, Pogoda K, Pohl U. Channel-independent influence of connexin 43 on cell migration. Biochim Biophys Acta. 2012;1818(8), 1993–2001.
Beltrán A, Hernández-Aragón L, Galindo Ramírez F. Estudio del cambio en el nivel intracelular de Ca2+ y su propagación en cé-lulas de una línea tumoral de pulmón gene-rados por la activación de una sustancia fo-tosensible. 5ª Reunión Anual del Colegio Mexicano para la Investigación del Cáncer. 2019; disponible en: https://www-op-tica.inaoep.mx/~tecnologia_salud/2019/tra-bajos_cartel.php
Castano AP, Demidova TN, Hamblin MR. Mechanisms in photodynamic therapy: part two-cellular signaling, cell metabolism and modes of cell death. Photodiagnosis Photo-dyn Ther. 2005;2(1), 1–23.
Whiteside TL. Tumor-Derived Exosomes and Their Role in Cancer Progression. Adv Clin Chem. 2016;74, 103–141.
Villagrasa A, Álvarez PJ, Osuna A, Garrido JM, Aránega A,Rodríguez-Serrano F. Exo-somes Derived from Breast Cancer Cells, Small Trojan Horses? J Mammary Gland Biol Neoplasia. 2014;19(3-4): 303–313.
Yang L, Wu XH, Wang D, Luo CL, Chen LX. Bladder cancer cell-derived exosomes in-hibit tumor cell apoptosis and induce cell proliferation in vitro. Mol Med Rep. 2013;8(4), 1272–1278.