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Colegio de Medicina Interna de México.

2022, Number 3

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Med Int Mex 2022; 38 (3)

Benefits of folinic acid as coadjuvant therapy

Pérez-Arenas LU, Torres-Ortega H, Escamilla-Zúñiga M, Cota-Peimbert C, Mares-Martínez MJ

Language: Spanish
References: 45
Page: 571-585
PDF size: 261.90 Kb.


ABSTRACT

Folinic acid plays a role in the synthesis and repair of DNA and therefore, it is essential for normal cellular metabolism. Consequently, the alteration of folate levels is related to various diseases in different apparatus and systems. A search in various scientific databases was made for original articles and case reports, published from 2010 to 2020. A total of 125 articles were collected, of which only 45 were selected with the aim of gathering and highlighting the beneficial effects of folinic acid on its use as coadjuvant therapy. Benefits were described in areas such as neurology, psychiatry, oncology, toxicology, infectology, dermatology, gastroenterology, and genetics. After the administration of folinic acid, the following benefits were obtained: in autistic patients, cognitive-behavioral functions improved, in those with schizophrenia, both positive and negative symptoms were attenuated, and in epileptic patients, seizures were controlled. In patients with HIV, folate plasma concentrations increased while serum homocysteine decreased. In addition, the synthesis of metalloproteinases and collagen were stimulated, promoting the cicatrization process. In hereditary folate malabsorption, systemic and neurological symptoms were completely eliminated, as well as improved psychomotor development and the developmental quotient in patients with Down syndrome. On the other hand, folinic acid increased the tolerance and efficacy of antineoplastic drugs. The neurological, intestinal and bone toxicity of methotrexate, as well as lamotrigine teratogenesis were decreased. Therefore, it was concluded that the benefits of the administration of folinic acid are broad and evident in the aforementioned diseases.


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