medigraphic.com
ISSN 1561-3046 (Electronic)

2021, Number 1

<< Back Next >>

Rev Cub Med Mil 2021; 50 (1)

Diagnosis of nephrosclerosis in autopsied deceased

Castañer MJB, Hurtado de Mendoza AJD, Montero GT, Fuentes AJ

Language: Spanish
References: 26
Page:
PDF size: 233.35 Kb.


ABSTRACT

Introduction: Nephrosclerosis occurs due to damage to the glomerular microvasculature. Vascular damage at the glomerular level reduces its functional capacity and the damage is accelerated due to high blood pressure, diabetes mellitus, obesity and other causes of kidney damage.
Objective: To identify the histopathological diagnosis of nephrosclerosis and describe characteristics of autopsied deceased with this entity.
Methods: 135,449 autopsied deceased in Cuba, aged 15 or over, between 1963 and 2015 were analyzed, the histopathological diagnoses of nephrosclerosis were reviewed. The diagnoses of direct cause of death and basic cause of death were also specified, as well as their association with other entities. It was also analyzed: age, sex, histopathological diagnosis of nephrosclerosis, diagnoses of direct and basic cause of death, and association with other pathological entities.
Results: There was a histopathological diagnosis of nephrosclerosis in 56,422 (40.2%), of them 91.8% were 55 years of age or older, 52.9% were male and 47.0% female. Bronchopneumonia (25.88%) was the main direct cause of death, atherosclerotic disorders and arterial hypertension were identified as the main basic causes of death.
Conclusions: There was a high percentage of nephrosclerosis diagnoses in autopsied deceased in Cuba, in a period of 52 years. Male patients over 55 years of age predominated, as well as the association with basic atherosclerotic diseases and arterial hypertension.


REFERENCES

  1. Heras M, García-Cosmes P, Fernández-Reyes MJ, Sánchez R. Evolución natural de la función renal en el anciano: análisis de factores de mal pronóstico asociados a la enfermedad renal crónica. Nefrología. 2013[acceso: 13/09/2020]; 33(4):462–9. Disponible en: http://scielo.isciii.es/pdf/nefrologia/v33n4/revision_corta2.pdf

  2. Shaoshan L, Weibo L, Dandan L, Hao C, Feng X, Huiping C, et al. Clinico – pathological characteristics and outcome of patients with biopsy – proven hypertensive nephrosclerosis: a retrospective cohort study. BMC Nephrology 2016[acceso: 13/09/2020]; 17(42):[aprox. 10 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827210/

  3. Marín R, Gorostidi M, Diez Oj B. Nefroangioesclerosis. La cenicienta de la enfermedad renal crónica. Nefrología. 2010[acceso: 13/09/2020]; 30(3):275-9. Disponible en: https://www.revistanefrologia.com/es-nefroangioesclerosis-la-cenicienta-enfermedad-renal-articulo-X0211699510035779

  4. Meyner A. Nephrosclerosis: a term in quest of a Disease. Nephron. 2015[acceso: 13/09/2020];129(4):276-82. Disponible en: https://pubmed.ncbi.nlm.nih.gov/25871843/

  5. Lavoz-Barria, Lavoz C, Droguett A, Burgos ME, Carpio DJ, Ortiz A, et al. Estudio traslacional de la vía Notch en nefropatía hipertensiva. Nefrología. 2014[acceso: 13/09/2020]; 34(3):369-76. Disponible en: https://revistanefrologia.com/es-estudio-traslacional-via-notch-nefropatia-articulo-X021169951405396X

  6. Reyes ME. Enfermedad renal crónica y ateromatosis van de la mano. La Habana: Infomed, Noticias de salud; 2019. [acceso: 13/09/2020]. Disponible en: https://boletinaldia.sld.cu/aldia/2019/10/24/enfermedad-renal-cronica-y-ateromatosis-van-de-la-mano/

  7. Nonko Uesugi. Age related renal Microvascular changes; evaluation by three – dimensional digital imaging of the human renal microvasculation using virtual microscopy. Int. J. Mol. Sci. 2016[acceso: 13/09/2020];17(11):1831. Disponible en: https://www.mdpi.com/1422-0067/17/11/1831

  8. Diez Ojea B, Marín R, Coto E, Fernández Vega F, Álvarez Navascués R, Fernández Fresnedo G, et al. Bases clínicas y genéticas de la nefroesclerosis hipertensiva: Estudio NEFROSEN. Nefrología. 2010[acceso: 13/09/2020]; 30(6):687-97. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0211-69952010000600014

  9. León Álvarez J, García Sánchez N, Gutiérrez Rojas A, Pérez Caballero M. Biomarcadores de daño renal en la hipertensión arterial esencial. Rev. Cub. Med. 2016[acceso: 13/09/2020]; 2016;55(4):297-310. Disponible en: https://www.medigraphic.com/cgi-bin/new/resumen.cgi?IDARTICULO=72981

  10. Meyner A. Nephrosclerosis: update on a centenarian. Nephrol Dial Transplant. 2015[acceso: 13/09/2020]; 30(11):1833–41. Disponible en: https://pubmed.ncbi.nlm.nih.gov/25488894/

  11. Hughson M, Puelles V, Hoy W, Douglas-Denton R, Mott S, Bertram J. Hypertension, glomerular hypertrophy and nephrosclerosis: the effect of race. Nephrol Dial Transplant. 2014[acceso: 13/09/2020]; 29(7):1399–409. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071048/

  12. Haruhara K, Tsuboi N, Kanzaki G, Koike K, Suyama M, Shimizu A, et al. Glomerular density in biopsy proven hypertensive Nephrosclerosis. American Journal of Hypertension. 2015[acceso: 13/09/2020]; 28(9):1164-71. Disponible en: https://academic.oup.com/ajh/article/28/9/1164/2743326

  13. Abboud H, Labreuche J, Duyckaerts C, Hauw JJ and Amarenco P.Prevalence of nephroangiosclerosis in patient with fatal stroke. Neurology. 2009[acceso: 13/09/2020]; 72(10):899–904. Disponible en: https://pubmed.ncbi.nlm.nih.gov/19273823/

  14. Denic A, Mariam PA, Kaushik V, Lerman LO, Lieske JC, Stegall MD. Detection and clinical patterns of nephron hypertrophy and nephrosclerosis among apparently healthy adults. Am J Kidney. 2016[acceso: 13/09/2020]; 68(1):58 – 67. Disponible en: https://pubmed.ncbi.nlm.nih.gov/26857648/

  15. Sumida K, Hoshino J, Ueno T, Mise K, Hayami N, Suwabe T. Effect of proteinuria and glomerular filtration rate on renal outcome in patients with biopsy proven benign nephrosclerosis. Plos One. 2016[acceso: 14/09/2020]; 11(1): e0147690. Disponible en: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0147690

  16. Malatino L, Stancanelli B, Giannakakis C, Marcantoni C. Nefroangiosclerosis: entita clínica definita? G Ital Nefrol. 2012[acceso: 14/09/2020]; 29(6):650 – 4. Disponible en: http://www.nephromeet.com/web/eventi/GIN/dl/storico/2012/6/GIN6_12_MALATINO_650-654.pdf

  17. Furuichi K, Shimizu M, Yuzawa Y, Hara A, Toyama T, Kitamura H, et al. Nationwide multicenter Kidney biopsy study of Japanese patients with hypertensive nephrosclerosis. Clin Exp Nephrol. 2018[acceso: 14/09/2020]; 22:629–37. Disponible en: https://link.springer.com/article/10.1007/s10157-017-1496-4

  18. Oliva Dámaso E, Sablón González N, Pérez Borges P, Parodis López E. Nefropatías vasculares. Medicine. 2015[acceso: 14/09/2020]; 11(80):4803–9. Disponible en: https://www.sciencedirect.com/science/article/pii/S0304541215001304

  19. Erten S, Gungor O, Sen S, Ozbek SS, Kircelli F, Hoscoskun C, et al. Nephrosclerosis and carotid atherosclerosis: lessons from Kidney donor histology. Nephrology. 2011[acceso: 14/09/2020]; 16(8):720–4. Disponible en: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1440-1797.2011.01499.x

  20. Rule AD, Cornell LD, Poggio ED. Senile nephrosclerosis. Does it explain the declive in glomerular filtration rate with aging?. Nephron Physiol. 2011[acceso: 14/09/2020]; 119(suppl 1):6–11. Disponible en: https://pubmed.ncbi.nlm.nih.gov/21832860/

  21. Iwakiri T, Sato Y, Matsuura Y, Hatakeyama K, Marutsuka K, Yamashita A, et al. Association between renal vasculature changes and generalized atherosclerosis an autopsy survey. J Atheroscler Thromb. 2014[acceso: 14/09/2020];21(2):99–107. Disponible en: https://pubmed.ncbi.nlm.nih.gov/24096900/

  22. Nakano T, Ninomiya T, Sumiyoshi S, Fujii H, Doi Y, Hirakata H, et al. Association of kidney function with coronary atherosclerosis and calcification in autopsy samples from Japanese elders. Hisayama study. Am J Kidney Dis. 2010[acceso: 14/09/2020]; 55(1):21–30. Disponible en: https://pubmed.ncbi.nlm.nih.gov/19765871/

  23. Suzuki H, Kobayashi K, Ishida Y, Kikuta T, Inoue T, et al. Patients with biopsy – proven nephrosclerosis and moderately impaired renal function have a higher risk for cardiovascular disease: 15 years experience in a single kidney disease center. Ther Adr Cardiovasc Dis. 2015[acceso: 14/09/2020]; 9(3):77–86. Disponible en: https://pubmed.ncbi.nlm.nih.gov/25838316/

  24. Shiraishi N, Kitamura K, Kohda Y, Iseki K, Tomita K. Prevalence and risk factors analysis of nephrosclerosis and ischemic nephropathy in the Japanese general population. Clinical and experimental. 2014[acceso: 14/09/2020]; 18(3):461–8. Disponible en: https://pubmed.ncbi.nlm.nih.gov/23832327/

  25. Abe M, Okada K, Maruyama N, Takashima H, Oikawa O, Soma M. Comparison of clinical trajectories before initiation of renal replacement therapy between diabetic nephropathy and nephrosclerosis on the KDIGO Guidelines Heat Map. Journal of Diabetes. 2016[acceso: 14/09/2020];2016:5374746. Disponible en: http://downloads.hindawi.com/journals/jdr/2016/5374746.pdf

  26. Haruyama N, Tsuchimoto A, Masutani K, Nagata M, Kitada H, Tanaka M, et al. Subclinical nephrosclerosis is linked to left ventricular hypertrophy independent of classical atherogenic factors. Hypertension Research. 2013[acceso: 14/09/2020]; 2014(37):472 – 7. Disponible en: https://www.nature.com/articles/hr2013154




2020     |     www.medigraphic.com