2022, Number 1
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Arch Neurocien 2022; 27 (1)
Detection of autism spectrum disorders using the questionnaire M-CHAT R / F: The importance of considering socio-cultural and language aspects
Martí C D, Aranda W, Eblen-Zajjur A
Language: Spanish
References: 39
Page: 16-22
PDF size: 202.22 Kb.
ABSTRACT
Introduction: The influence of language and socio-cultural environment on the development of cortical
connections is widely acknowledged, as well as the alteration of the latter in contexts of autism spectrum
disorders (ASD). The present study evaluated potential differences in the detection of ASD, depending
on the language and socio-cultural aspects of the population.
Method: A search of publications was
carried out in: PubMed, Google Scholar, and Epistemonikos from 2010 to 2020, which validated the
use of the M-CHART R/F questionnaire as screening in the early ASD detection in patients between 12
and 36 months of age, without risk factors and in any country in the world. The meta-analysis included
three reviewers who evaluated eligibility and extracted the data. The heterogeneity and consistency
between studies, as well as the specific differences between each one with the main validation study were
evaluated, including, the positivity of the phase 1 and its confirmation in the follow-up of each case.
Results: Eight articles met the inclusion criteria; these were carried out in the United States, Argentina,
France, Spain, Turkey, Saudi Arabia, Albania and Korea, in their official languages, for a total of 36,842
children. Heterogeneity was low (OR‹0.42) for most subsets of the meta-analysis, except for the results
obtained in Korea (OR=7.64). There is an association in results between countries (excluding Korea)
OR=0.196 [0.178-0.216]; p‹10-10. All studies showed significant differences in detection compared
to the original validation study.
Conclusion: The MCHAT R/F is a valid method for screening for
suspected ASD in the general population, but it is dependent of the culture and language of the country.
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