Machado-Curbelo C

Language: English
References: 5
Page: 85-86
PDF size: 121.47 Kb.

Text Extraction

A perplexing clinical aspect of COVID-19 is presentation of patients with pronounced hypoxemia without expected signs of respiratory distress or dyspnea, even when cyanotic. Nonetheless, these patients frequently leapfrog clinical evolution stages and suffer acute respiratory distress syndrome (ARDS), with concomitant cardiorespiratory arrest and death. This phenomenon is referred to as silent or ‘happy’ hypoxemia.

REFERENCES

1. Machado-Curbelo C. Severe Covid-19 cases: Is respiratory distress partially explained by central nervous system involvement? MEDICC Rev [Internet]. 2020 Apr [cited 2020 May 15];22(2):38–41. Available at: https://mediccreview .org/severe-covid-19-cases-is-respiratory-distress-partially-explained-by-cen tral-nervous-system-involvement/

2. Anoop UR, Verma K. Happy hypoxemia in COVID-19. A neural hypothesis. ACS Chem Neurosci. 2020 Jul 1;11(13):1865–7.

3. Dhont S, Derom E, Van Braeckel E, Depuydt P, Lambrecht BN. The pathophysiology of “happy” hypoxemia in COVID-19. Respir Res. 2020 Jul 28;21(1):198.

4. Tobin MJ, Laghi F, Jubran A. Why COVID-19 silent hypoxemia is baffl ing to physicians. Am J Respir Crit Care Med. 2020 Aug 1;202(3):356–60.

5. González-Duarte A, Norcliffe-Kaufmann L. Is “happy hypoxia”’ in COVID-19 a disorder of autonomic interoception? A hypothesis. Clin Auton Res. 2020 Aug;30(4):331–3.