2022, Number 03
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Ginecol Obstet Mex 2022; 90 (03)
Papilliferous hidradenoma of the vulva with carcinoma in situ component: case report and literature review
Hernández JA, Calderón P, Melo-Uribe MA, Bárcenas L
Language: Spanish
References: 15
Page: 300-306
PDF size: 218.75 Kb.
ABSTRACT
Background:Vulvar cancer is relatively rare, representing less than 1% of malignant tumors in women; its incidence increases with age. The most frequent variety is squamous cell carcinoma (80 to 90%), followed by melanoma. In this report we review a carcinoma of glandular origin, such as papilliferous hydradenoma of the vulva of the mammary gland (mammary-like) type.
Clinical case: We present a 50-year-old patient with 2 years evolution of a papular lesion on the vulva with slow and progressive growth, intermitent sensation of mass and pain, with negative colposcopy, no history of breast pathology and with a previous biopsy that reported vulvar papilliferous hydradenoma. She was treated with complete resection of the lesion under regional anesthesia, with free margins, without identifying an infiltrating component and currently without evidence of relapse or requirement of additional treatments.
Conclusion: Papilliferous hidradenoma is a rare benign lesion related to the mammary-like anogenital glands, with a good prognosis and its recommended treatment is surgical excision, which is generally curative.
REFERENCES
Vivas-Flores CI, Pantoja-Garrido M, Holgado-Hernández A. Adenocarcinoma primario de vulva tipo glándula mamaria. Forma histológica muy infrecuente de neoplasia vulvar. Clin Invest Gin Obst 2018; 45 (4): 187-92. http://dx.doi.org/10.1016/j.gine.2017.03.004
JJ, Ahmed I. Adenocarcinoma of mammary-like glands of the vulva. Report of a case and review of the literature. Am J Dermatopathol 2006; 28: 127-33. https://doi-org.ezproxy.umng.edu.co/10.1097/01.dad.0000171601.25315.2b
Konstantinova AM, Michal M, Kacerovska D, Spagnolo DV, et al. Hidradenoma Papilliferum: A clinicopathologic study of 264 tumors from 261 patients, with emphasis on Mammary-type alterations. Am J Dermatopathol 2016; 0: 1-10. https://doi-org.ezproxy.umng.edu.co/10.1097/dad.0000000000000495
Castro CY, Deavers M. Ductal carcinoma in-situ arising in mammary-like glands of the vulva. Int J Gynecol Pathol 2021; 20 (3). https://doi-org.ezproxy.umng.edu.co/10.1097/00004347-200107000-00012
van der Putte SCJ, van Gorp LHM. Adenocarcinoma of the mammary-like glands of the vulva: a concept unifying sweat gland carcinoma of the vulva, carcinoma of the supernumerary mammary glands and extramammary Paget’s disease. J Cutan Pathol 1994; 21: 157-63. https://doi-org.ezproxy.umng.edu.co/10.1111/j.1600-0560.1994.tb00251.x
Pelosi G, Martignoni G, Bonetti F. Intraductal carcinoma of the mammary type apocrine epithelium arising within a papillary hydradenoma of the vulva: report of a case and review of the literature. Arch Pathol Lab Med 1991; 115: 1249-54.
Kazakov DV, Spagnolo DV, Kacerovska D, Michal M. Lesions of anogenital mammary-like glands: An update. Adv Anat Pathol 2011; 18: 1-28. https://doi-org.ezproxy.umng.edu.co/10.1097/pap.0b013e318202eba5
Vazmitel M, Spagnolo DV, Nemcova J, Michal M, Kazakov DV. "Hidradenoma Papilliferum with a ductal carcinoma in situ component: Case report and review of the literature." (“Hidradenoma papilliferum with a ductal carcinoma in situ ...”) Extraordinary case report. Am J Dermatopathol 2008; 30: 392-94. https://doi-org.ezproxy.umng.edu.co/10.1097/dad.0b013e31817c6a7d
van der Putte SCJ. Mammary-like glands of the vulva and their disorders. Review. Int J Gynecol Pathol 1994,13 (2):150-60. https://doi-org.ezproxy.umng.edu.co/10.1097/00004347-199404000-00009
Konstantinova AM, Colin JR. Kyrpychova SL, et al. An immunohistochemical study of anogenital mammary-like glands. Am J Dermatopathol 2017; 39: 599-605. https://doi-org.ezproxy.umng.edu.co/10.1097/dad.0000000000000724
Blind A, Weingertner N, Cribier B. Anatomoclinical and immunohistochemical study of hidradenoma papilliferum, a tumor deriving from anogenital mammary-like glands. Annales de Dermatologie et de Vénéréologie 2019; 146: 528-36. https://doi-org.ezproxy.umng.edu.co/10.1016/j.annder.2019.03.008
Shah SS, Adelson M, Mazur MT. Adenocarcinoma in situ arising in vulvar papillary hidradenoma: report of 2 cases. Int J Gynecol Pathol 2008; 27: 453-56. https://doi-org.ezproxy.umng.edu.co/10.1097/pgp.0b013e31815b8eee
Kazakov DV, Nemcova J, Mikyskova I, et al. Human papillomavirus in lesions of anogenital mammary-like glands. Int J Gynecol Pathol 2007; 26: 475-80. https://doi-org.ezproxy.umng.edu.co/10.1097/pgp.0b013e31803104af
Sington J, Chandrapala R, Manek S, Hollowood K. Mitotic count is not predictive of clinical behavior in hidradenoma Papilliferum of the vulva. A Clinicopathologic study of 19 cases. Am J Dermatopathol 2006; 28: 322-26. https://doi-org.ezproxy.umng.edu.co/10.1097/00000372-200608000-00005
Konstantinova AM, Vanecek T, Martinek P, Kyrpychova L, et al. Molecular alterations in lesions of anogenital mammary-like glands and their mammary counterparts including hidradenoma papilliferum, intraductal papilloma, fibroadenoma and phyllodes tumor. Annals of Diagnostic Pathology 2017; 28: 12-18. https://doi-org.ezproxy.umng.edu.co/10.1016/j.anndiagpath.2017.02.004.