Vick FR, Hidalgo LH, Zenón MC, Martínez S

Language: Spanish
References: 16
Page: 141-144
PDF size: 99.54 Kb.

ABSTRACT

Glycyrrhizin acid is a glycosan triterphenoid activated in the carboxilic groups 5, 10 and 20. It is extracted from Glycyrrhiza glabra root. It have been proven to have antiviral activity against DNA and RNA virus (VZV, HIV, Influenza A and B, types 1 and 2 herpes simplex and hepatitis B and C) in vitro an in vivo. Toxicity has not been found in experimental trials on different cell lines. The Glycyrrhizin acid blocks the first steps on viral replication as well as the viron exit from the capside. This is an open, controlled, clinical and multicentric study to evaluate the efficacy, safety and tolerability of the glycirrhizin acid. 52 adults patients of both sexes (males 62.7%, females 37.3%) with age ranging from 18 to 65 years (mean 38.8) with active lesions of genital herpes simplex were included in this preliminary study. Patients the cases were enrolled under clinical, cytologic and immunologic criteria.
A local application of the spray solution on the affected area was done twice a day for 5 days. Clinical efficacy was evaluated with no parametric methods. Total efficacy was observed in 95%, it was excellent in 65%, good in 25% and mild in 9%. The natural history was the same, but not so good were the control of pain and pruritus. The immuno-serological evolution was correlated with the clinical history. Local tolerability was of 94.1% and non important adverse side events were observed.

REFERENCES

1. Brown TJ, Yen-Moore A, Tyring SK. An overview of sexually transmitted diseases. Part 1. J Am Acad Dermatol 1999; 41: 511-529.

2. Habif TP. Clinical Dermatology, a Color Guide to Diagnosis and Therapy. 3ª Ed., Mosby Year Book, St Louis, 1996.

3. Boletín Epidemiológico, Sistema Único de Información para la Vigilancia Epidemiológica, Secretaría de Salud. México.

4. Finney RSH, Sommers GF. The anti-inflammatory activity of glycyrrhizin acid and derivatives. Pharmacol 1958; 110: 613-620.

5. Doll R, Hill ID, Hutton C and Underwood DJ. Clinical trial of a triterpenoid liquorice compound in gastric and duodenal ulcer. Lancet 1962; 2: 793-796.

6. Abe N, Ebina T, Ishida N. Interferon induction by glycyrrhizin and glycyrrhizin acid in mice. Microbiol Immunol 1982; 26: 535-539.

7. Pompei R, Flore O, Marccialis MA, Pani A, Loddo B. Glycyrrhizin acid inhibits virus growth and inactivates virus particles. Nature l979; 281: 689-690.

8. Baba M, Shigeta S. Antiviral activity of glycyrrhizin against: varicella-zoster virus in vitro. Antiviral Res 1987; 7: 99-107.

9. Ito M, Nakashima H, Baba M, Pauwels R, De Clerc E, Shigeta S, Yamamoto N. Inhibitory effect of glycyrrhizin on the in vitro infectivity and cytopathic activity of the human immunodeficiency virus [HIV(HTLV, III/LAV)]. Antiviral Res 1987; 7: 127-137.

10. Takahara T, Watanabe A, Shiraki K. Effects of Glycyrrhizin on hepatitis B surface antigen: a biochemical and morphological study. J Hepatol 1994; 21(4): 601-609.

11. Ohtsuki K, Lahida N. Inhibitory effect of Glycyrrhizin on polypeptide phosphorylation by poli peptide-dependent protein kinase (kinase P) in vitro. Biochem Byophys Res Commun 1998; 157: 597-604.

12. Corey L. Herpes simplex virus. in Mandell GL, Bennett JE, Dolin R. Principles and Practice of Infectious Diseases, 5a Ed., Churchill Livingstone, Philadelphia, 2000.

13. Ashley R, Cent A, Maggs V. Inability of enzyme immunoassays to discriminate between infections with herpes simplex virus 1 or 2. Ann Intern Med 1991; 115: 520-526.

14. Nahmias AJ, Lee TK, Beckman-Nahmias S. Seroepidemiological and sociological patterns of herpes simplex virus infections in the world. Scand J Infect Dis 1990; 69(suppl): 19-36.

15. McClung H, Pradeep S, Rawls WE. Relative concentrations in human sera of antibodies to cross-reacting and specific antigens of herpes simplex virus type and 2. Am J Epidemiol 1976; 104: 192-201.

16. Barton SE. Sexually transmitted diseases, Herpes management and prophylaxis. Dermatologic clinics 1998; 16: 799-803.