2021, Number 1
Obesity in diabetes mellitus: a great danger to the heart and life
Language: Spanish
References: 14
Page: 118-123
PDF size: 229.56 Kb.
Text Extraction
To the Editor:It is with concern and regrettable foresight that I turn to you, seeing that the comorbidity of obese patients is becoming an epidemic. It is no longer only obesity that is of concern, but also the changes of all kinds that take place in organ structure and function –including the cell that pose a great danger to the heart and life.
In an article referring to coronary microcirculation and the clinical-epidemiological variables found in 117 diabetic patients with myocardial infarction and normal coronary arteries, a significant prevalence of overweight (19.7%) and obesity (80.3%) was observed. This takes place despite the new drugs available for glycemic control and the maintenance of acceptable, even normal, glycosylated hemoglobin parameters. The sodium-glucose cotransporter-2 (SGLT-2) inhibitors, empagliflozin and canagliflozin and the GLP-1 (glucagon-like peptide-1) receptor agonists, liraglutide and semaglutide; have decreased the risk of cardiovascular death, myocardial infarction and stroke, once they were added to the therapeutic protocols for patients with type 2 diabetes mellitus. Many of these patients have overweight or obesity, which multiplies their risk of complications and adverse events during their lifetime.
REFERENCES
Ortega FB, Sui X, Lavie CJ, Blair SN. Body mass index, the most widely used but also widely criticized index: Would a criterion standard measure of total body fat be a better predictor of cardiovascular disease mortality? Mayo Clin Proc. 2016;91(4):443-55. DOI: https://doi.org/10.1016/j.mayocp.2016.01.008
Gil-Ortega M, Condezo-Hoyos L, García-Prieto CF, Arribas SM, González MC, Aranguez I, et al. Imbalance between pro and anti-oxidant mechanisms in perivascular adipose tissue aggravates long-term high-fat diet-derived endothelial dysfunction. PLoS One [Internet]. 2014 [citado 16 Mar 2020];9(4):e95312. Disponible en: https://doi.org/10.1371/journal.pone.0095312
Ochoa Montes LA, González Lugo M, Vilches Izquierdo E, Fernández-Britto Rodríguez JE, Araujo González RE; Sección de Investigación en Muerte Súbita de la Sociedad Cubana de Aterosclerosis. Muerte súbita cardiovascular en poblaciones de riesgo. CorSalud [Internet]. 2014 [citado 21 Mar 2020];6(Supl 1):71-8. Disponible en: http://www.corsalud.sld.cu/suplementos/2014/v6s1a14/pob-riesgo.html