medigraphic.com
ISSN 2078-7170 (Electronic)

2021, Number 1

<< Back Next >>

CorSalud 2021; 13 (1)

Global longitudinal strain value in the early detection of chemotherapy-induced cardiotoxicity

Torres GS, Hechavarría PS, Fernández CJA, Álvarez PR, González CSC, Milán RD

Language: Spanish
References: 23
Page: 32-43
PDF size: 771.79 Kb.


ABSTRACT

Introduction: Advances in early detection and treatment of cancer have significantly reduced mortality. The net result is the emergence of a cohort of patients whose survival is sufficient to evidence the side effects of the used therapies. Cardiotoxicity is the set of cardiovascular diseases resulting from onco-hematological treatments.
Objectives: To evaluate the role of global longitudinal strain in the early detection of cardiotoxicity in patients undergoing chemotherapy.
Method: A quantitative, analytical, prospective, longitudinal study was carried out in 44 patients diagnosed with breast cancer or lymphoma, who started chemotherapy treatment at the Instituto de Oncología y Radiobiología of Cuba, from February 2017 to April 2018. Primary and secondary methods were used for raw data collection and several statistical tests were used for its analysis.
Results: The mean age and treatment period were 47.7 years old and 5.05 months, respectively. The most prevalent risk factor was high blood pressure and cardiotoxicity was higher (27.8%) in patients with previous diastolic dysfunction. Among those who developed cardiotoxicity, the variable that showed the greatest affectation was global longitudinal strain (p<0.0001), with a reduction of 19.6% with respect to the basal one.
Conclusions: Global longitudinal strain is an echocardiographic index of myocardial performance, which presented a significant discriminating value with respect to cardiotoxicity in patients who received chemotherapeutic treatment.


REFERENCES

  1. López-Fernández T, Martín García A, Santaballa Beltrán A, Montero Luis A, García Sanz R, Mazón Ramos P. Cardio-Onco-Hematología en la práctica clínica. Documento de consenso y recomendaciones. Rev Esp Cardiol. 2017;70(6):474-86. DOI: https://doi.org/10.1016/j.recesp.2016.12.021

  2. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70(1):7-30. DOI: https://doi.org/10.3322/caac.21590

  3. Villasmil Camacho JK, Escudero E. Evaluación ecocardiográfica de la función ventricular derecha para la detección temprana de la cardiotoxicidad inducida por antraciclinas. Insuf Card. 2017;12(2):62-90.

  4. Caro Codón J, Rosillo Rodríguez SO, López Fernández T. Cardiotoxicity from the cardiologist's perspective. Future Cardiol. 2015;11(4):425-32. DOI: https://doi.org/10.2217/fca.15.47

  5. Kocabay G, Muraru D, Peluso D, Cucchini U, Mihaila S, Padayattil-Jose S, et al. Mecánica ventricular izquierda normal mediante ecocardiografía speckle tracking bidimensional. Valores de referencia para adultos sanos. Rev Esp Cardiol. 2014;67(8):651-8. DOI: https://doi.org/10.1016/j.recesp.2013.12.011

  6. Mele D, Rizzo P, Pollina AV, Fiorencis A, Ferrari R. Cancer therapy-induced cardiotoxicity: role of ultrasound deformation imaging as an aid to early diagnosis. Ultrasound Med Biol. 2015;41(3):627-43. DOI: https://doi.org/10.1016/j.ultrasmedbio.2014.11.015

  7. Gilchrist SC, Barac A, Ades PA, Alfano CM, Franklin BA, Jones LW, et al. Cardio-Oncology Rehabilitation to Manage Cardiovascular Outcomes in Cancer Patients and Survivors: A Scientific Statement From the American Heart Association. Circulation. 2019;139(21):e997-e1012. DOI: https://doi.org/10.1161/cir.0000000000000679

  8. Fallah-Rad N, Walker JR, Wassef A, Lytwyn M, Bohonis S, Fang T, et al. The utility of cardiac biomarkers, tissue velocity and strain imaging, and cardiac magnetic resonance imaging in predicting early left ventricular dysfunction in patients with human epidermal growth factor receptor II-positive breast cancer treated with adjuvant trastuzumab therapy. J Am Coll Cardiol. 2011;57(22):2263-70. DOI: https://doi.org/10.1016/j.jacc.2010.11.063

  9. Lang RM, Badano LP, Mor-Avi V, Spencer KT, Tsang W, Voigt JU, et al. Recomendations for cardiac Chamber Quantification by Echocardiography in Adults: An Update from the American Society of Echocardiography and the European Association Of Cardiovascular Imaging. J Am Soc Echocardiogr. 2015;28(1):1-39. DOI: https://doi.org/10.1016/j.echo.2014.10.003

  10. Menting ME, McGhie JS, Koopman LP, Vletter WB, Helbing WA, van den Bosch AE, et al. Normal myocardial strain values using 2D speckle tracking echocardiography in healthy adults aged 20 to 72 years. Echocardiography. 2016;33(11):1665-75. DOI: https://doi.org/10.1111/echo.13323

  11. Nagueh SF, Smiseth OA, Appleton CP, Byrd BF, Dokainish H, Edvardsen T, et al. Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2016;29(4):277-314. DOI: https://doi.org/10.1016/j.echo.2016.01.011

  12. Rudski LG, Lai WW, Afilalo J, Hua L, Handschumacher MD, Chandrasekaran K, et al. Guidelines for the echocardiographic assessment of the right heart in adults: A report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. J Am Soc Echocardiogr. 2010;23(7):685-713;quiz786-8. DOI: https://doi.org/10.1016/j.echo.2010.05.010

  13. Chibuzor Nwuruku G, Prohías Martínez J, Castro Arca Á, Mérida Álvarez O, Brooks Tamayo J, García Hernández R. Detección precoz de cardiotoxicidad inducida por antraciclinas. CorSalud [Internet]. 2014 [citado 16/09/2020];6(3):229-34. Disponible en: http://www.revcorsalud.sld.cu/index.php/cors/article/view/159/371

  14. Sawaya H, Sebag IA, Plana JC, Januzzi JL, Ky B, Cohen V, et al. Early detection and prediction of cardiotoxicity in chemotherapy-treated patients. Am J Cardiol. 2011;107(9):1375-80. DOI: https://doi.org/10.1016/j.amjcard.2011.01.006

  15. López-Fernández T, Thavendiranathan P. Nuevas técnicas de imagen cardiaca en la detección precoz de cardiotoxicidad secundaria a tratamientos oncológicos. Rev Esp Cardiol. 2017;70(6):487-95. DOI: https://doi.org/10.1016/j.recesp.2016.12.027

  16. Takigiku K, Takeuchi M, Izumi C, Yuda S, Sakata K, Ohte N, et al. Normal range of left ventricular 2-dimensional strain: Japanese Ultrasound Speckle Tracking of the Left Ventricle (JUSTICE) study. Circ J. 2012;76(11):2623-32. DOI: https://doi.org/10.1253/circj.cj-12-0264

  17. Cheng S, Larson MG, McCabe EL, Osypiuk E, Lehman BT, Stanchev P, et al. Reproducibility of speckle-tracking-based strain measures of left ventricular function in a community-based study. J Am Soc Echocardiogr. 2013;26(11):1258-66.e2. DOI: https://doi.org/10.1016/j.echo.2013.07.002

  18. Farsalinos KE, Daraban AM, Ünlü S, Thomas JD, Badano LP, Voigt JU. Head-to-Head comparison of global longitudinal strain measurements among nine different vendors: The EACVI/ASE Inter-Vendor Comparison Study. J Am Soc Echocardiogr. 2015;28(10):1171-81.e2. DOI: https://doi.org/10.1016/j.echo.2015.06.011

  19. Kang Y, Xu X, Cheng L, Li L, Sun M, Chen H, et al. Two-dimensional speckle tracking echocardiography combined with high-sensitive cardiac troponin T in early detection and prediction of cardiotoxicity during epirubicine-based chemotherapy. Eur J Heart Fail. 2014;16(3):300-8. DOI: https://doi.org/10.1002/ejhf.8

  20. Narayan HK, Finkelman B, French B, Plappert T, Hyman D, Smith AM, et al. Detailed echocardiographic phenotyping in breast cancer patients: Associations with ejection fraction decline, recovery, and heart failure symptoms over 3 years of follow-up. Circulation. 2017;135(15):1397-412. DOI: https://doi.org/10.1161/circulationaha.116.023463

  21. Tang Q, Jiang Y, Xu Y, Xia H. Speckle tracking echocardiography predicts early subclinical anthracycline cardiotoxicity in patients with breast cancer. J Clin Ultrasound. 2017;45(4):222-30. DOI: https://doi.org/10.1002/jcu.22434

  22. Velásquez CA, González M, Berrouet MC, Jaramillo N. Cardiotoxicidad inducida por la quimioterapia desde las bases moleculares hasta la perspectiva clínica. Rev Colomb Cardiol. 2016;23(2):104-11. DOI: http://dx.doi.org/10.1016/j.rccar.2015.10.002

  23. Negishi K, Negishi T, Hare JL, Haluska BA, Plana JC, Marwick TH. Independent and incremental value of deformation indices for prediction of trastuzumab-induced cardiotoxicity. J Am Soc Echocardiogr. 2013;26(5):493-8. DOI: https://doi.org/10.1016/j.echo.2013.02.008




2020     |     www.medigraphic.com