2022, Number 1
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Acta Med 2022; 20 (1)
Acute pancreatitis associated with COVID-19
Hernández GL, Alvarado DJ, Novelo PJE, Sánchez ARA
Language: Spanish
References: 10
Page: 12-16
PDF size: 145.85 Kb.
ABSTRACT
Introduction: In December 2019 the first atypical pneumonia case was reported in China; caused by SARS-CoV-2. It affects mainly the respiratory tract. New studies have reported gastrointestinal symptoms as initial manifestations of COVID-19 infection and there are few reports that have linked SARS-CoV-2 to the occurrence of acute pancreatitis.
Objective: To describe the appearance of pancreatitis and its correlation with the rest of the clinical manifestations, and consider the pancreas as a target organ of this virus, which could worsen the prognosis of these patients.
Material and methods: This is a descriptive, cross-sectional, retrospective, non-experimental case series study conducted from March 15 to May 25, 2020. The study area corresponds to all patients who entered the intensive care area with COVID-19 PCR diagnosis. The variables studied were collected from the clinical file.
Results: From thirty patients in the intensive care, eight of them presented laboratory and CT scan data compatible with acute pancreatitis. All cases have lymphopenia, the elevation of amylase and lipase, hyperbilirubinemia, and only one case showed vesicular lithiasis without demonstrating the cause of pancreatitis. It was used to stage the severity SOFA and APACHE score, all patients died in an average of days of stay in intensive care of 9.8.
REFERENCES
Xu B, Kraemer MUG; Open COVID-19 Data Curation Group. Open access epidemiological data from the COVID-19 outbreak. Lancet Infect Dis. 2020; 20 (5): 534.
Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020; 395 (10223): 507-513.
Dirección General de Epidemiología. Secretaría de Salud [Internet]. Datos abierto dirección general de epidemiología. Información importante Coronavirus COVID-19. 2020 [citado 8 julio 2020]. Disponible en: https://www.gob.mx/salud/documentos/datos-abiertos-152127
Lankisch PG, Apte M, Banks PA. Acute pancreatitis. Lancet. 2015; 386 (9988): 85-96.
Rawla P, Bandaru SS, Vellipuram AR. Review of infectious etiology of acute pancreatitis. Gastroenterology Res. 2017; 10 (3): 153-158.
Dalan R, Bornstein SR, El-Armouche A, Rodionov RN, Markov A, Wielockx B et al. The ACE-2 in COVID-19: foe or friend? Horm Metab Res. 2020; 52 (5): 257-263.
Liu F, Long X, Zhang B, Zhang W, Chen X, Zhang Z. ACE2 Expression in pancreas may cause pancreatic damage after SARS-CoV-2 infection. Clin Gastroenterol Hepatol. 2020; 18 (9): 2128-2130.
Baron M, Veres A, Wolock SL, Faust AL, Gaujoux R, Vetere A et al. A Single-cell transcriptomic map of the human and mouse pancreas reveals inter- and intra-cell population structure. Cell Syst. 2016; 3 (4): 346-360.
Oyelade T, Alqahtani J, Canciani G. Prognosis of COVID-19 in patients with liver and kidney diseases: an early systematic review and meta-analysis. Trop Med Infect Dis. 2020; 5 (2): 80.
Wang F, Wang H, Fan J, Zhang Y, Wang H, Zhao Q. Pancreatic injury patterns in patients with coronavirus disease 19 pneumonia. Gastroenterology. 2020; 159 (1): 367-370.