2020, Number S1
Extra-pulmonary manifestations of the novel coronavirus infection SARS-CoV-2
Language: Spanish
References: 56
Page: 1-17
PDF size: 796.73 Kb.
ABSTRACT
Introduction: Coronaviruses are a large family of viruses that can cause diseases in both animals and humans. The SARS-CoV-2 is a new virus that belongs to the Orthocoronavirinae subfamily. The infection can be mild, moderate or severe regarding the form of presentation and the accompanying symptoms. When there are no complications, the viral infection of the upper respiratory tract is accompanied by nonspecific symptoms like fever, cough, sore throat, nasal congestion, general malaise, headaches and muscle pain.Objective: To describe the extra-pulmonary manifestations of the novel coronavirus infection SARS-CoV-2.
Material and Methods: A bibliographic review from a total of 56 references was made; articles and information in Spanish and English languages available from databases such as PubMed/MedLine, SciELO, Scopus and other open access journals were used.
Development: Different authors have reported extra-pulmonary manifestations in patients with COVID-19. Nausea, vomiting, diarrhea and hepatic lesions among others have been reported in the digestive system; arterial hypotension, arrhythmias and myocarditis have been found in the cardiovascular system; acute kidney injury has been observed in the renal system; hyponatremia was reported in a case in the endocrine-metabolic system; epilepsy, anosmia, cerebrovascular disease and others have been observed in the neurological system; additionally, cutaneous manifestations have been observed as exanthematic lesions.
Conclusions: Besides the lung manifestations typical of pneumonia that the novel coronavirus infection SARS-CoV-2 causes, extra-pulmonary manifestations can be present in other systems such as: the digestive, cardiovascular, endocrine-metabolic, neurological, and renal ones. Skin lesions can also occur.
REFERENCES
Carr D. Sharing research data and findings relevant to the novel coronavirus (COVID-19) outbreak [Internet]. London: Wellcome Trust; 2020. [Citado 12/03/2020]. Disponible en: Disponible en: https://wellcome.ac.uk/press-release/sharingresearch-data-and-findings-relevant-novelcoronavirus-covid-19-outbreak
Hui DS, Azhar EI, Madani TA, Ntoumi F, Kock R, Dar O, et al. The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health. The latest 2019 novel coronavirus outbreak in Wuhan, China. Int J Infect Dis [Internet]. 2020 [Citado 05/05/2020];91:264-6. Disponible en: Disponible en: http://dx.doi.org/10.1016/j.ijid.2020.01.009
Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin. BioRxiv [Internet]. New York: Cold Spring Harbor; 2020 [Citado 05/05/2020]. Disponible en: Disponible en: http://dx.doi.org/10.1101/2020.01.22.914952
Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet [Internet]. 2020 [Citado 05/05/2020];395:565-74. Disponible en: Disponible en: http://dx.doi.org/10.1016/S0140-6736(20)30251-8
Chan J, Yuan S, Kok K, To K, Chu H, Yang J, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet . [Internet]. 2020 [Citado 05/05/2020];395:514-23. Disponible en: Disponible en: http://dx.doi.org/10.1016/s0140-6736(20)30154-9
World Health Organization. 2019-nCoV outbreak is an emergency of international concern [Internet]. Genova: World Health Organization; 2020 [Citado 12/04/2020]. Disponible en: Disponible en: http://www.euro.who.int/en/health-topics/healthemergencies/international-healthregulations/news/news/2020/2/2019-ncovoutbreak-is-an-emergency-of-internationalconcern
World Health Organization. WHO Director-General's opening remarks at the media briefing on COVID-19-11 March 2020 [Internet]. Genova: World Health Organization ; 2020 [Citado 15/04/2020]. Disponible en: Disponible en: https://www.who.int/dg/speeches/detail/whodirector-general-s-opening-remarks-at-the-mediabriefing-on-covid-19---11-march-2020
Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet [Internet]. 2020 [Citado 05/05/2020];395:507-13. Disponible en: Disponible en: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30211-7/fulltext
Zeng JH, Liu Y, Yuan J, Wang F, Wu W, Li J, et al. First Case of COVID-19 Infection with Fulminant Myocarditis Complication: Case Report and Insights. Nature Public Health Emergency Collection [Internet] Bethesda: National Center for Biotechnology Information; 2020. [Citado 05/05/2020]. Disponible en: Disponible en: https://www.preprints.org/manuscript/202003.0180/v1
Guo T, Fan Y, Chen M, Wu X, Zhang L, He T, et al. Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID-19). JAMA Cardiol [Internet]. 2020 [Citado 05/05/2020]5(1):[aprox. 4 p.]. Disponible en: Disponible en: https://jamanetwork.com/journals/jamacardiology/fullarticle/10.1001/jamacardio.2020.1017
Shi S, Qin M, Shen B,Cai Y, Liu T, Yang F, et al. Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China. JAMA Cardiol [Internet]. 2020 [Citado 05/05/2020]5(1):[aprox. 4 p. Disponible en: Disponible en: https://jamanetwork.com/journals/jamacardiology/fullarticle/10.1001/jamacardio.2020.0950
Sociedad Interamericana de Cardiología SIAC. Afectación cardiovascular por coronavirus a propósito de la nueva epidemia por 2019-nCoV. [Internet]. Washington: Sociedad Interamericana de Cardiología; 2020 [Citado 25/03/2020]. Disponible en: Disponible en: http://www.siacardio.com/consejos/consejo-de-cardiologia-tropical/editoriales-consejo-de-cardiologia-tropical/afectacion-cardiovascular-por-coronavirus-a-proposito-de-la-nueva-epidemia-por-2019-ncov/
De la Flor Merino JC, Reyes LM, Gravalos TL, Conde AR, Pozo MR. Inusual caso de Hiponatremia aguda grave en paciente con Infección por COVID-19. Nefrología [Internet]. 2020 [Citado 25/03/2020];40:[aprox. 2 p.]. Disponible en: Disponible en: https://www.revistanefrologia.com/es-inusual-caso-hiponatremia-aguda-grave-avance-S0211699520300497
Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, et al. Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China. JAMA Neurol. [Internet]. 2020 Abr [Citado 05/05/2020];323:[aprox. 3 p.]. Disponible en: Disponible en: https://jamanetwork.com/journals/jamaneurology/fullarticle/2764549
Matías Guiu J, Gómez Pinedo U, Montero Escribano P, Gómez Iglesias P, Porta Etessam J, Matias Guiu JA. ¿Es esperable que haya cuadros neurológicos por la pandemia por SARS-CoV-2?. Neurología [Internet]. 2020 [Citado 05/05/2020];35(3):170-5. Disponible en: Disponible en: https://www.elsevier.es/es-revista-neurologia-295-avance-resumen-es-esperable-que-haya-cuadros-S0213485320300657
Li YC, Bai WZ, Hashikawa T. The neuroinvasive potential of SARS-CoV2 may be at least partially responsible for the respiratory failure of COVID-19 patients. J Med Virol . [Internet]. 2020 [Citado 05/05/2020];92:[aprox. 2 p.]. Disponible en: Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/32104915
Zhao H, Shen D, Zhou H, Liu J, Chen S. Guillain-Barré syndrome associated with SARS-CoV-2 infection: causality or coincidence?. Lancet Neurol [Internet]. 2020 [Citado 05/05/2020];19(5):383-4. Disponible en: Disponible en: https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(20)30109-5/fulltext
Mao L, Wang M, Chen S, He Q, Chang J, Hong C, et al. Neurological manifestations of hospitalized patients with COVID-19 in Wuhan, China: a retrospective case series study. SSRN Journal [Internet]. 2020 [Citado 05/05/2020];29:[aprox. 2 p.]. Disponible en: Disponible en: https://doi.org/10.1101/2020.02.22.20026500
Ollarves Carrero MF, Rodríguez Morales AG, Bonilla Aldana DK, Rodríguez Morales A J. Anosmia in a healthcare worker with COVID-19 in Madrid, Spain. Travel Medicine and Infectious Disease [Internet]. 2020. [Citado 05/05/2020];33:[aprox. 2 p.]. Disponible en: Disponible en: http://dx.doi.org/10.1016/j.tmaid.2020.101666
Lechien JR, Chiesa Estomba CM, De Siati DR, Horoi M, Le Bon SD, Rodríguez A, et al. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. European Archives of Oto-Rhino-Laryngology [Internet]. 2020 [Citado 05/05/2020];277:[aprox. 2 p.]. Disponible en: Disponible en: https://doi.org/10.1007/s00405-020-05965-1
Morey Olivé M, Espiau M, Mercadal Hally M, Lera Carballo E, García Patos V. Manifestaciones cutáneas en contexto del brote actual de enfermedad por coronavirus 2019. An Pediatr (Barc) [Internet]. 2020 May [Citado 05/05/2020];92:[aprox. 2 p.]. Disponible en: Disponible en: https://doi.org/10.1016/j.anpedi.2020.04.013
Iglesias Pertuz S, Aroca Martínez G, Vélez Verbel M, Cadena Osorio A, Cadena Bonfanti A, Correa Monterrosa M, et al. Reporte de 4 casos COVID-19 hospitalizados en unidad de cuidados intensivos en una institución hospitalaria en Barranquilla, Colombia. Rev Colomb Nefrol [Internet]. 2020 [Citado 05/05/2020];7(Supl 2):[aprox. 25 p.]. Disponible en: Disponible en: https://revistanefrologia.org/index.php/rcn/article/view/420