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Boletín Clínico de la Asociación Médica del Hospital Infantil del Estado de Sonora

2021, Number 1

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Bol Clin Hosp Infant Edo Son 2021; 38 (1)

Ivermectin in the prophylaxis and treatment of SARS-CoV-2 coronavirus, yes or not?

Anzures-Gutiérrez SA, Reyes-Gómez U, Echeverría-Mayrén C, Reyes-Hernández KL, Pila-Aranda G, Aquino-Villagómez DY, Alonso-Pérez NC, Reyes-Hernández MU, López-Cruz G, Matos-Alviso LJ, Soria-Saavedra FM, Arista-Viveros A

Language: Spanish
References: 53
Page: 34-47
PDF size: 179.69 Kb.


ABSTRACT

Ivermectin is a semisynthetic macrocyclic lactone derived from the actinomycete Streptomyces avermitilis. Macrocyclic lactones are important precursor compounds in the chemistry of macrolide antibiotics, antifungals, polyene macrolides and some macrocyclic anticancer antibiotics, all are structural derivatives of macrocyclic lactones. It is an available and affordable medicine, it is on the “World Health Organization (WHO) List of Essential Medicines” and with a long history of clinical safety, the medicine is already in clinical trials around the world. It has a proven record of safety in human use, with the total doses distributed in the last 30 years equivalent to one third of the current world population. In safety, tolerability, and pharmacokinetic studies, it is generally well tolerated, with no indication of CNS-associated toxicity for doses up to 10 times the highest dose. On a large scale, the interventions carried out in Peru, Brazil, Paraguay and India indicate that after the massive distribution of the drug among the population, the incidence rates of the disease fell significantly. There are various international groups in favor of the drug, recommending its use and conducting studies such as the FLCCC, Tratamientotemprano.org, among others. Worldwide there are more than 50 published studies and others in process, the NIH has withdrawn the restriction for its use and the WHO is conducting an exhaustive review considering that there are promising results.


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