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2021, Number 2

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Rev Mex Patol Clin Med Lab 2021; 68 (2)

Evaluation of a rapid test versus a chemiluminescent microparticle immunoassay for the detection of antibodies against SARS-CoV-2

Lara-Sanjuan F, Parra-Ortega I, Sánchez PS, Alcaraz RD, Rodríguez MF, López-Martínez B

Language: Spanish
References: 18
Page: 45-50
PDF size: 274.51 Kb.


ABSTRACT

Introduction: Serology allows us to quickly detect SARS-CoV-2 positive patients, isolate them and cut the epidemiological chain; Therefore, lateral flow assays have been designed to identify IgG/IgM antibodies in serum. In Mexico, COFEPRIS approved several rapid tests, used for diagnosis of COVID-19. Material and methods: The Vazyme 2019-nCoV IgG/IgM kit, was evaluated sensitivity and specificity compared to the results of two automated immunoassays, SARS-CoV-2 IgG/IgM (ARCHITECT, Abbott), using serum from 75 patients diagnosed with SARS-CoV-2 and 25 negative to SARS-CoV-2. Results: Sensitivity and specificity were obtained individually (100 and 52% IgG Vazyme, 15.2% and 100% IgM Vazyme) and globally 100%, 60%, respectively. Conclusion: We show that the Vazyme rapid test performs underperforming compared to the ARCHITECT test, so its use for COVID diagnosis is limited its use for the diagnosis of COVID-19.


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