2020, Number 4
Prognostic factors of mortality rate in patients with spontaneous intracerebral hemorrhage
Language: Spanish
References: 17
Page: 1-13
PDF size: 395.96 Kb.
ABSTRACT
Introduction: spontaneous intracerebral hemorrhage (ICH) is considered, among all strokes, the one having the most devastating effect, the estimated mortality rate per month ranges between 35 and 52 %.Objective: to determine the factors that influence 30-day mortality rate in patients with Spontaneous Intracerebral Hemorrhage.
Methods: a cross-sectional, analytical, observational study conducted at Dr. Carlos Juan Finlay Military Hospital over a period of 3 years (2017 to 2019). The target group comprised 75 patients. Demographic, clinical and tomographic variables were studied. Descriptive statistics was applied: absolute and relative frequency, arithmetic mean and standard deviation; along with inferential statistics: logistic regression using the Odds Ratio with a 95 % confidence interval, for a positive significance on p <0.05.
Results: the age group from 48 to 75 years prevailed with 45 patients (60 %), male sex 44 patients (58. 7%), and white race 33 (44 %). Hypertension predominated as the main antecedent in 61 patients (81. 3 %). Significantly positive results were obtained for ages over 80 (p = 0,001); the severe state according to Glasgow Coma Scale (p = 0,005); the presence of ventricular extension (p = 0,001) and treatment with oral anticoagulants (p = 0.023).
Conclusions: intracerebral hemorrhage is evidence for extensive mortality rates. People over 80 years old, treated with oral anticoagulants have a higher risk of death due to this entity. Ventricular extension and a low score on the Glasgow Coma Scale worsen the prognosis.
REFERENCES
Macías Ruíz V, Cordero Pérez MB, Vásquez Cedeño D, Saltos Mata F. Factores Asociados a la Mortalidad de la Hemorragia Cerebral Intraparenquimatosa Espontánea en Pacientes Mayores de 50 Años de Edad que Acudieron al Hospital Teodoro Maldonado Carbo Durante el Año 2017. Rev. Ecuat. Neurol. [internet] 2019 [citado 13/12/2019]; 28 (1): 10-15. Disponible en: Disponible en: http://scielo.senescyt.gob.ec/scielo.php?script=sci_abstract&pid=S2631-25812019000100010&lng=es&nrm=iso
Suárez-Quesada A, Álvarez-Aliaga A, López-Espinosa E, Bárzaga-Morell S, Santisteban-García A. Pronóstico de muerte en pacientes con hemorragia intracerebral supratentorial espontánea. Revista Finlay [revista en Internet]. 2016 [citado 11/12/2019]; 6(1): [aprox. 8 p.]. Disponible en: Disponible en: http://revfinlay.sld.cu/index.php/finlay/article/view/408
Ropper AH, Samuels MA. Enfermedades Cerebrovasculares. En: Adams y Victor: Principios de Neurología. Parte IV. Capítulo 35. Décima Edición. McGraw-Hill: México; [internet] 2016 [citado 13/12/2019]. Disponible en: Disponible en: https://es.slideshare.net/kevinarmijosm/adams-victor-principiosneurologiafororinconmedicotk
Chen S, Zhao B, Wang W, Shi L, Cesar Reis C, Zhang J. Predictors of hematoma expansion predictors after intracerebral hemorrhage. Oncotarget, [internet] 2017 [citado 13/12/2019]; 8(51): 89348-63. Disponible en: Disponible en: https://www.ncbi.nlm.nih.gov/m/pubmed/29179524&sa=U&ved=2ahUKEwi1-pat_PDoAhWNmuAKHcAgAvQQFjABegQIABAB&usg=AOvVaw0jYGj6VBAa_ki0KDf8Ys64
Øie LR, Mattis A, Madsbu, Solheim O, Asgeir S, Jakola, Giannadakis C, Vorhaug A, et al. Functional outcome and survival following spontaneous intracerebral hemorrhage: A retrospective population‐based study. Brain and Behavior. [internet] 2018 [citado 13/12/2019]; 8: e01113. Disponible en: Disponible en: https://dx.doi.org/10.1002/brb3.1113
Green L, Tan J, Morris JK, Alikhan R, Curry R, Everington T, et al. A three-year prospective study of the presentation and clinical outcomes of major bleeding episodes associated with oral anticoagulant use in the UK (ORANGE study). Haematol [internet] 2018 [citado 13/12/2019]; 103 (4): 738-745. Disponible en: Disponible en: http://www.doi:10.3324/haematol.2017.182220
Hemphill JC, Bonovich DC, Besmertis L, Manley GT, Johnston SC. The ICH score: a simple, reliable grading scale for intracerebral hemorrhage. Stroke. [internet] 2001 [citado 13/12/2019]; 32: 891-7. Disponible en: Disponible en: https://www.ncbi.nlm.nih.gov/m/pubmed/11283388&sa=U&ved=2ahUKEwiZ_LzK_PDoAhXCmeAKHcdXA0AQFjACegQICBAB&usg=AOvVaw0tAAlvTgKZn7qkHyTyku_N
Méndez Fleitas L, Carmona Denis Y, Moreno Peña LE, Escalona Robaina CR, Ortega Peñate JA. Caracterización clínica de la hemorragia intracerebral en pacientes ingresados en Hospital Faustino Pérez. 2012-2013. Rev Méd Electrón [Internet]. 2019 Ene-Feb [citado: 12/12/2019]; 41(1). Disponible en: Disponible en: http://www.revmedicaelectronica.sld.cu/index.php/rme/article/view/2985/4172
Clarke JL, Johnston SC, Farrant M, Bernstein R, Tong D, Hemphill JC 3rd. External validation of the ICH score. Neurocrit Care [internet] 2004 [citado 13/12/2019]; 1(1): 53-60. Disponible en: Disponible en: http://neurocriticalcare.pbworks.com/f/ICH%2BScore%2Bvalidation%2Bpaper.pdf&sa=U&ved=2ahUKEwjU1JXw_PDoAhWLUt8KHecyC5QQFjAFegQIAxAB&usg=AOvVaw01VJGjKqnGNDwt-C9zeG9i
Pérez García AR, García Monter A, Sosa Acosta EF, Padrón Valdés F. Factores pronósticos de mortalidad por hemorragia intracerebral en el periodo agudo. Rev Cub de Medic Milit. [internet] 2015 [citado 13/12/2019]; 44 (3): 277-88. Disponible en: Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0138-65572015000300002
Brito F, Correiras J, Neves D, Valdir E, Farias L, Ferreira R, et al. Hemorragia Intracerebral Espontánea Estudio retrospectivo de 72 casos operados. Arq Neuropsiquiatr [internet] 2000 [citado 13/12/2019]; 58(2-B): 499-504. Disponible en: Disponible en: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2000000300016
Safatli, D. A., Gunther, A., Schlattmann, P., Schwarz, F., Kalff, R., & Ewald, C. Predictors of 30‐day mortality in patients with spontaneous primary intracerebral hemorrhage. Surg Neurol International [internet]2016 [citado 13/12/2019]; 7 (Suppl. 18), S510-S517. Disponible en: Disponible en: https://dx.doi.org/10.4103/2152-7806.187493
Rahmani F, Rikhtegar R, Ala A, Farkhad-Rasooli A, Ebrahimi-Bakhtavar H. Predicting 30-day mortality in patients with primary intracerebral hemorrhage: Evaluation of the value of intracerebral hemorrhage and modified new intracerebral hemorrhage scores. Iran J Neurol [internet] 2018 [citado 13/12/2019]; 17(1): 47-52. Disponible en: Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121209/
Li Q, Huang YJ, Zhang G, Lv FJ, Wei X, Dong MX, et al. Intraventricular hemorrhage and early hematoma expansion in patients with intracerebral hemorrhage. Scientific Reports. [internet] 2015 [citado 13/12/2019]; 5. Disponible en: Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471897/&sa=U&ved=2ahUKEwjiiNvw_vDoAhVvmeAKHfl8B1QQFjACegQICBAB&usg=AOvVaw2K36N-K0FJW7k2nIC7mn1f