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2019, Number 3

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Rev Cubana Plant Med 2019; 24 (3)

Chemical profiles and efficacy of essential oils obtained from three spices against Helicobacter pylori

Tabti M, Merouane A, Allem R

Language: English
References: 32
Page: 1-13
PDF size: 439.08 Kb.


ABSTRACT

Introduction: the medicinal herbs constitute one of the most preferred alternative solutions as antimicrobial agents due to their availability, biodegradability, fewer side effects. Unfortunately, rare are the studies focused on the efficacy of plant extracts against Helicobacter pylori to either confirm or refute their effectiveness.
Objective: determinate the chemical profiles and evaluate the antibacterial activity against Helicobacter pylori of the essential oils obtained from Eugenia caryophyllata, Foeniculum vulgare and Carum carvi.
Methods: the essential oils obtained from flower buds of Eugenia caryophyllata and seeds of Foeniculum vulgare and Carum carvi were extracted by hydrodistillation. The antibacterial potency against local clinical isolate of Helicobacter pylori was tested using agar disc diffusion and minimum inhibitory concentration techniques and the chemical composition was determined via gas chromatography-mass spectrometry.
Results: the phytochemical analysis identified trans-anethole (43.01%), estragole (27.04%) and fenchone (06.63%) as main compounds in F. vulgare oil. Carvone and α -pinene were defined as major components of C. carvi oil with 63.92% and 8.43% respectively, whereas the abundant constituents of E. caryophyllata were eugenol (65.22%), eugenyl acetate (18.77%) and trans-caryophyllene (9.92%). The strongest anti H. pylori activity was exhibited by F. vulgare oil reaching similar action of Clarithromycin (p < 0.05) used as positive control.
Conclusion: this is the first report showing the potency of essential oils from spices against H. pylori, the results indicated that these resources can constitute potential natural treatment.


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