2021, Number 4
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Acta Med 2021; 19 (4)
Incidence of the location of fractures in the multiple myeloma in the Regional Hospital ''Gral. Ignacio Zaragoza'' ISSSTE
Carrillo SAM, De SELA, Pérez GCK, Antonio RCE, Pérez ZJM, Añorve BD
Language: Spanish
References: 17
Page: 497-500
PDF size: 163.09 Kb.
ABSTRACT
Multiple myeloma is a hematological neoplasm derived from alterations in B lymphoid cells characterized by skeletal abnormalities called multiple myeloma bone disease.
Objective: Determine the location of fractures in patients with multiple myeloma at the Regional Hospital "Gral. Ignacio Zaragoza" from 2016 to 2019.
Material and methods: Retrospective study, we reviewed the radiological clinical records of patients diagnosed with multiple myeloma in the period from January 2016 to December 2019.
Results: We included 33 patients with multiple myeloma. Three patients (9.1%) presented a fracture with characteristics of a neoplastic process and subsequent diagnosis of multiple myeloma. Other patients had symptoms of multiple myeloma bone disease: low back pain 42.4% (n = 14), generalized bone pain 15.2% (n = 5). In 24 patients, we documented a fracture associated with multiple myeloma: spine 39.4% (n = 13), humerus 12.1% (n = 4), hip 9.1% (n = 3), appendicular skeleton 9.1% (n = 3) and femur 3% (n = 1).
Conclusion: 24 patients (78.7%) were diagnosed with a fracture associated with multiple myeloma, being more frequent in the spine, humerus, and hip.
REFERENCES
Gerecke C, Fuhrmann S, Strifler S, Schmidt-Hieber M, Einsele H, Knop S. The diagnosis and treatment of multiple myeloma. Dtsch Arztebl Int. 2016; 113 (27-28): 470-476.
Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin. 2013; 3 (1): 11-30.
Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer Statistics, 2009. CA Cancer J Clin. 2009; 59 (4): 225-249.
Alvarado-Ibarra M, Álvarez-Vera JL, Anaya-Cuéllar I, De la Peña-Celaya A, García-Fernández L, Hernández-Ruiz E et al. Primer Consenso Nacional de Mieloma Múltiple por Hematólogos del ISSSTE. Rev Hematol Mex. 2015; 16 (4): 306-332.
Ries LAG, Young JL, Keel GE, Eisner MP, Lin YD, Horner MJ (editors). SEER survival monograph: cancer survival among adults: U.S. SEER Program, 1988-2001, patient and tumor characteristics. National Cancer Institute, SEER Program. NIH Pub. No. 076215, 2007.
Brigle K, Rogers B. Pathobiology and diagnosis of multiple myeloma. Semin Oncol Nurs. 2017; 33 (3): 225-236.
Walker RE, Lawson MA, Buckle CH, Snowden JA, Chantry AD. Myeloma bone disease: pathogenesis, current treatments and future targets. Br Med Bull. 2014; 111 (1): 117-138.
Terpos E, Christoulas D, Gavriatopoulou M. Biology and treatment of myeloma related bone disease. Metabolism. 2018; 80: 80-90.
Melton LJ 3rd, Kyle RA, Achenbach SJ, Oberg AL, Rajkumar SV. Fracture risk with multiple myeloma: a population-based study. J Bone Miner Res. 2005; 20 (3): 487-493.
Herget GW, Wasch R, Klein L, Schmal H, Terpos E, Engelhardt M. Prevention of bone disease and early detection of impending fractures in multiple myeloma patients can reduce morbidity and mortality: the necessity of interdisciplinary state-of-the-art treatment. Haematologica. 2020; 105 (4): 859-861.
Abildgaard N, Brixen K, Kristensen JE, Vejlgaard T, Charles P, Nielsen JL. Assessment of bone involvement in patients with multiple myeloma using bone densitometry. Eur J Haematol. 1996; 57 (5): 370-376.
Rajkumar SV, Dimopoulos MA, Palumbo A, Blade J, Merlini G, Mateos MV et al. International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol. 2014; 15 (12): 538-548.
Sharma AM, Sackett M, Bueddefeld D, Lambert P, Dubey A, Wadhwa V et al. Incidence of spinal disease and role of spinal radiotherapy in multiple myeloma. Curr Oncol. 2018; 25 (6): 539-544.
Terpos E, Morgan G, Dimopoulos MA, Drake MT, Lentzsch S, Raje N et al. International Myeloma Working Group recommendations for the treatment of multiple myeloma-related bone disease. J Clin Oncol. 2013; 31 (18): 2347-2357.
Thorsteinsdottir S, Gislason G, Aspelund T, Sverrisdottir I, Landgren O, Turesson I et al. Fractures and survival in multiple myeloma: Results from population-based study. Haematologica. 2020; 105 (4): 1067-1073.
Derlin T, Bannas P. Imaging of multiple myeloma: current concepts. World J Orthop. 2014; 5 (3): 272-282.
Bryson DJ, Wicks L, Ashford RU. The investigation and management of suspected malignant pathological fractures: a review for the general orthopaedic surgeon. Injury. 2015; 46 (10): 1891-1899.