Vega-Gonzáles EO, Arnao-Degollar V, García-Cajaleón J

Language: Spanish
References: 27
Page: 857-864
PDF size: 205.64 Kb.

ABSTRACT

Objective: To compare maternal complications in pregnant women with a positive diagnosis of acute and past COVID-19 attended in two health facilities in Metropolitan Lima, Peru.
Materials and Methods: Descriptive, analytical and retrospective study carried out in pregnant patients attended in two maternal and child centers of Metropolitan Lima from June to December 2020 in whom the COVID-19 antibody test was applied. The data collected were transferred to a matrix of the SPSS 25 program and analyzed with Fisher's exact test, calculation of odds ratio and 95%CI.
Results: 177 pregnant women with a positive report to a rapid One Step test for Novel Coronavirus (2019-nCov) IgM/IgG Antibody (Colloidal Gold) were analyzed. Most had past infection with IgG alone (50.0%), followed by acute infection with IgM and IgG (43.2%). Only 6.8% had early-stage infection, identified only with IgM. The only complication with significant difference between COVID-19 positive pregnant women with acute infection and past infection was premature rupture of membranes, with a value of p = 0.019 with Fisher's exact test. The most frequent maternal complication was premature rupture of membranes with 16.4%, and delivery was terminated by cesarean section in 27.7%. Only a significant association was found between acute infection and premature rupture of membranes (p = 0.019; OR = 2.563 CI95%: 1.115-5.892).
Conclusion: Premature rupture of membranes was the only maternal complication that had a significant association with acute COVID-19 infection during pregnancy.

REFERENCES

1. Wastnedge E, Reynolds RM, van Boeckel SR, Stock SJ, et al. Critchley H. Pregnancy and COVID-19. Physiological reviews 2021; 101 (1): 303-18. https://doi.org/10.1152/ physrev.00024.2020

2. Fondo de Población de las Naciones Unidas. Comunicado del UNFPA sobre el nuevo coronavirus (COVID-19) y el embarazo. Nueva York: UNFPA, 2020. https://www.unfpa. org/es/press/comunicado-del-unfpa-sobre-el-nuevocoronavirus- covid-19-y-el-embarazo

3. Mullins E, Evans D, Viner RM, O'Brien P, et al. Coronavirus in pregnancy and delivery: rapid review. Ultrasound Obstet Gynecol 2020; 55 (5): 586-92. https://doi.org/10.1002/ uog.22014

4. Wang S, Guo L, Chen L, Liu W, et al. A case report of neonatal COVID-19 infection in China. Clin Infect Dis 2020; ciaa225. https://doi.org/10.1093/cid/ciaa225

5. Panahi L, Amiri M, Pouy S. Risks of Novel Coronavirus Disease (COVID-19) in Pregnancy; a Narrative Review. Arch Acad Emerg Med 2020; 8 (1):e34. https://www.ncbi.nlm. nih.gov/pmc/articles/PMC7092922/

6. Zaigham M, Andersson O. Maternal and perinatal outcomes with COVID-19: A systematic review of 108 pregnancies. Acta Obstet Gynecol Scand 2020; 99 (7): 823-29. https://doi.org/10.1111/aogs.13867

7. Pereira A, Cruz S, Adrien M, Fuentes L, et al. Clinical course of coronavirus disease-2019 in pregnancy. Acta Obstet Gynecol Scand 2020; 99 (7): 839-47. https://doi. org/10.1111/aogs.13921

8. Liu H, Liu F, Li J, Zhang T, et al. Clinical and CT imaging features of the COVID-19 pneumonia: Focus on pregnant women and children. J Infect 2020; 80 (5): e7-e13. https:// doi.org/10.1016/j.jinf.2020.03.007

9. Pierce RAM, Burd J, Felder L, Khoury R, et al. Clinical course of severe and critical COVID-19 in hospitalized pregnancies: a US cohort study. Am J Obstet Gynecol MFM 2020; 100134. https://doi.org/10.1016/j.ajogmf.2020.100134

10. Di Mascio D, Khalil A, Saccone G, Rizzo G, et al. Outcome of Coronavirus spectrum infections (SARS, MERS, COVID-19) during pregnancy: a systematic review and meta-analysis. Am J Obstet Gynecol MFM 2020; 2 (2): 100107. https:// doi.org/10.1016/j.ajogmf.2020.100107

11. Zhang L, Jiang Y, Wei M, Cheng B, et al. Analysis of the pregnancy outcomes in pregnant women with COVID-19 in Hubei Province. Zhonghua Fu Chan Ke Za Zhi 2020; 55 (3): 166-71. https://pubmed.ncbi.nlm.nih.gov/32145714/

12. Liao J, He X, Gong Q, Yang L, et al. Analysis of vaginal delivery outcomes among pregnant women in Wuhan, China during the COVID-19 pandemic. Int J Gynaecol Obstet 2020; 150 (1): 53-57. https://doi.org/10.1002/ijgo.13188

13. Lopes de Sousa ÁF, Carvalho HEF, Oliveira LB, Schneider G, et al. Effects of COVID-19 infection during pregnancy and neonatal prognosis: what is the evidence? Int J Environ Res Public Health 2020; 17 (11): 4176. https://doi.org/10.3390/ijerph17114176

14. Pacheco J, Ciudad A, Guzmán A. Pruebas para el COVID- 19 en la gestante y su interpretación. Rev Peru Ginecol Obstet 2020; 66 (2): 00015. http://www. scielo.org.pe/scielo.php?script=sci_arttext&pid=S2304- 51322020000200015&lng=es

15. Ministerio de Salud. Prevención y atención de personas afectadas por Covid-19 en el Perú. Lima: MINSA, 2020. https://cdn.www.gob.pe/uploads/document/file/574377/ Documento_Te%CC%81cnico_Atencio%CC%81n_y_Manejo_ Cli%CC%81nico_de_Casos_de_COVID-19.pdf

16. Dirección General de Medicamentos. Listado de pruebas rápidas otorgadas en el contexto de la emergencia sanita ria declarada por el COVID-19 con valores de desempeño (sensibilidad-especificidad). Lima: DIGEMID, MINSA, 2020. https://www.digemid.minsa.gob.pe/upload/uploaded/ PDF/COVID19/AE_PRUEBAS_RAPIDAS.pdf

17. Rana S, Lemoine E, Granger JP, Karumanchi SA. Preeclampsia: Pathophysiology, Challenges, and Perspectives. Circulation rResearch 2019; 124 (7): 1094-12. https://doi. org/10.1161/CIRCRESAHA.118.313276

18. Picot M. Amenaza de parto pretérmino. Matronas profesión 2004; 5 (17): 30-36. https://www.federacionmatronas. org/revista/wp-content/uploads/2018/01/ vol5n17pag30-36.pdf

19. Acho SC, Salvador J, Díaz JA, Paredes JR. Hemorragia de la segunda mitad del embarazo en un hospital nacional de Lima. Rev Peru Ginecol Obstet 2011; 57 (4): 243-47. http://www.scielo.org.pe/scielo.php?script=sci_ arttext&pid=S2304-51322011000400006&lng=es

20. Rivera R, Caba F, Smirnow M, Aguilera J, et al. Fisiopatología de la rotura prematura de las membranas ovulares en embarazos de pretérmino. Rev Chil Obstet Ginecol 2004; 69 (3): 249-55. http://dx.doi.org/10.4067/S0717- 75262004000300013

21. Huertas E. Parto pretérmino: causas y medidas de prevención. Rev Peru Ginecol Obstet 2018; 64 (3): 399- 404. http://www.scielo.org.pe/scielo.php?pid=S2304- 51322018000300013&script=sci_arttext

22. Mylonas I, Friese K. Indications for and risks of elective cesarean section. Deutsches Arzteblatt international 2015; 112 (29-30): 489-95. https://doi.org/10.3238/ arztebl.2015.0489

23. Vera E, Montenegro I, Cruzate V, Marcelo H, et al. Gestación en tiempos de pandemia COVID-19. Hospital Nacional Docente Madre Niño San Bartolomé, Lima, Perú. Rev Peru Ginecol Obstet 2020; 66 (3): 00003. http://www. scielo.org.pe/scielo.php?script=sci_arttext&pid=S2304- 51322020000300003&lng=es

24. Guevara E, Carranza C, Zevallos K, Espinola M, et al. Prevalencia y caracterización de gestantes seropositivas para SARS-CoV-2. Revista Peruana de Investigación Materno Perinatal 2020; 9 (2): 13-20. https://investigacionmaternoperinatal. inmp.gob.pe/index.php/rpinmp/ article/view/198

25. Guevara E, Espinola M, Carranza C, Ayala F, et al. Anticuerpos anti-SARS-CoV-2 en gestantes en un hospital nivel III de Perú. Revista Peruana de Ginecología y Obstetricia 2020; 66 (3). http://www.scielo.org.pe/scielo.php?pid=S2304- 51322020000300002&script=sci_arttext

26. Huerta I, Elías JC, Campos K, Muñoz R, et al. Características materno perinatales de gestantes COVID-19 en un hospital nacional de Lima, Perú. Rev Peru Ginecol Obstet 2020; 66 (2): 00003. http://www.scielo.org.pe/scielo. php?script=sci_arttext&pid=S2304-51322020000200003

27. Vielma S, López M, Bustos JC, Assar R, et al. Parto prematuro en pacientes COVID-19 en Hospital San Juan de Dios. Rev Chil Obstet Ginecol 2020; 85 (Suppl 1): S59-S66. http:// dx.doi.org/10.4067/S0717-75262020000700009 s