medigraphic.com
ISSN 2007-8560 (Print)
Órgano Oficial de Difusión Científica de la Federación Mexicana de Colegios de Ortopedia y Traumatología, A.C. (FEMECOT)

2021, Number 4

<< Back Next >>

Ortho-tips 2021; 17 (4)

Plasma rich in growth factors in orthopedics, a path to orthobiologics in Mexico

Sánchez AR, Izquierdo MJF, Gutiérrez-Mendoza I, Rodríguez BÁ, Carrillo GJL, García BM, Cugat BR

Language: Spanish
References: 67
Page: 222-236
PDF size: 320.93 Kb.


ABSTRACT

PRP creates a path to attract progenitor cells, organizing the interaction of cytokines and growth factors to stimulate natural healing as well as improving strength, motion and normal function recovery of injured tissue. There are systematic reviews and meta-analysis that suggest that PRP relieves pain in patients with knee OA for more than 12 months. Superior to cortisone and hyaluronic acid, PRP is considered the gold standard treatment for pain associated with knee OA. Likewise, it has been proven that it is the most effective tool for the conservative management of lateral epicondylitis, medial gluteal tendinopathy, and patellar tendinopathy. In rotator cuff tendinopathy there are level I studies that favor PRP regarding pain and function improvement, with a faster recovery time. However, the lack of high-quality evidence has limited the acceptance of its widespread use. Recent research favors PRP vs corticosteroids as the conservative treatment for rotator cuff disease. PRP firmly stands out as a powerful natural analgesic and anti-inflammatory in addition to having regenerative potential by acting as a signaler for mesenchymal cells of our own body in the site where is applied. This treatment should be already in our daily practice as another tool that would set aside the use and overuse of corticosteroid injections, as well as the administration of analgesics, non-steroidal anti-inflammatory drugs, pondering the risk-cost benefits.


REFERENCES

  1. Khan KM, Cook JL, Bonar F, et al. Histopathology of common tendinopathies: update and implications for clinical management. Sports Med. 1999; 27 (6): 393-408.

  2. Coombes BK, Bisset L, Vicenzino B. Efficacy and safety of corticosteroid injections and other injections for management of tendinopathy: a systematic review of randomised controlled trials. Lancet. 2010; 376 (9754): 1751-1767.

  3. Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma: Growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998; 85 (6): 638-646.

  4. Bansal H, Leon J, Pont JL, Wilson DA, Bansal A, Agarwal D, et al. Platelet-rich plasma (PRP) in osteoarthritis (OA) knee: Correct dose critical for long term clinical efficacy. Sci Rep. 2021; 11 (1): 3971.

  5. Boswell SG, Cole BJ, Sundman EA, et al. Platelet-rich plasma: a milieu of bioactive factors. Arthroscopy. 2012; 28 (3): 429-439.

  6. Blair P, Flaumenhaft R. Platelet alpha-granules: basic biology and clinical correlates. Blood Rev. 2009; 23 (4): 177-189.

  7. Malanga GA, Goldin M. PRP: review of the current evidence for musculoskeletal conditions. Curr Phys Med Rehabil Rep. 2014; 2: 1-5.

  8. Magalon J, Bausset O, Serratrice N, Giraudo L, Aboudou H, Veran J, et al. Characterization and comparison of 5 platelet-rich plasma preparations in a single-donor model. Arthroscopy. 2014; 30 (5): 629-638.

  9. Mautner K, Blazuk J. Where do injectable stem cell treatments apply in treatment of muscle, tendon, and ligament injuries? PM R. 2015; 7 (4 Suppl): S33-S40.

  10. Anitua E, Sanchez M. A new biological approach to orthopedic surgery and sports medicine. España: Team Work Media; 2013. pp. 40-52.

  11. Descalzi F, Ulivi V, Cancedda R, Piscitelli F, Luongo L, Guida F, et al. Platelet-rich plasma exerts antinociceptive activity by a peripheral endocannabinoid-related mechanism. Tissue Eng Part A. 2013; 19 (19-20): 2120-2129.

  12. Le ADK, Enweze L, DeBaun MR, Dragoo JL. Current clinical recommendations for use of platelet-rich plasma. Curr Rev Musculoskelet Med. 2018; 11: 624-634.

  13. Anitua E, Sanchez M. A new biological approach to orthopedic surgery and sports medicine. España: Team Work Media; 2013. pp. 55-71.

  14. Li H, Hicks JJ, Wang L, Oyster N, Philippon MJ, Hurwitz S, et al. Customized platelet-rich plasma with transforming growth factor β1 neutralization antibody to reduce fibrosis in skeletal muscle. Biomaterials. 2016; 87: 147-156.

  15. Miroshnychenko O, Chang WT, Dragoo JL. The use of platelet-rich and platelet-poor plasma to enhance differentiation of skeletal myoblasts: implications for the use of autologous blood products for muscle regeneration. Am J Sports Med. 2017; 45 (4): 945-953.

  16. Anitua E, Sanchez M. A new biological approach to orthopedic surgery and sports medicine. España: Team Work Media; 2013. pp. 74-86.

  17. Kon E, Di Matteo B, Delgado D, Cole BJ, Dorotel A, Dragoo JL, et al. Platelet-rich plasma for the treatment of knee osteoarthristis: an expert opinión and proposal for a novel classification and coding system. Expert Opin Biol Ther. 2020; 20 (12): 1447-1460.

  18. Goldring MB, Goldring SR. Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis. Ann N Y Acad Sci. 2010; 1192: 230-237.

  19. Suri S, Walsh DA. Osteochondral alterations in osteoarthritis. Bone. 2012; 51 (2): 204-211.

  20. Mapp PI, Walsh DA. Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis. Nat Rev Rheumatol. 2012; 8 (7): 390-398.

  21. Imhof H, Sulzbacher I, Grampp S, Czerny C, Youssefzadeh S, Kainberger F. Subchondral bone and cartilage disease: a rediscovered functional unit. Invest Radiol. 2000; 35 (10): 581-588.

  22. Malinin T, Ouellette EA. Articular cartilage nutrition is mediated by subchondral bone: a long-term autograft study in baboons. Osteoarthritis Cartilage. 2000; 8 (6): 483-491.

  23. Aaron RK, Racine J, Dyke JP. Contribution of circulatory disturbances in subchondral bone to the pathophysiology of osteoarthritis. Curr Rheumatol Rep. 2017; 19 (8): 49.

  24. Moussa M, Lajeunesse D, Hilal G, El Atat O, Haykal G, Serhal R, et al. Platelet rich plasma (PRP) induces chondroprotection via increasing autophagy, anti-inflammatory markers, and decreasing apoptosis in human osteoarthritic cartilage. Exp Cell Res. 2017; 352 (1): 146-156.

  25. Milano G, Sánchez M, Jo CH, Saccomanno M, Thampatty BP, Wang JHC. Platelet-rich plasma in orthopaedic sports medicine: state of art. JISAKOS. 2019; 4: 188-195.

  26. Delgado D, Garate A, Vincent H, Bilbao AM, Patel R, Fiz N, et al. Current concepts in intraosseous Platelet-Rich Plasma injections for knee osteoarthritis. J Clin Orthop Trauma. 2019; 10 (1): 36-41.

  27. Montañez-Heredia E, Irízar S, Huertas PJ, Otero E, Del Valle M, Prat I, et al. Intra-articular injections of platelet-rich plasma versus hyaluronic acid in the treatment of osteoarthritic knee pain: a randomized clinical trial in the context of the Spanish national health care system. Int J Mol Sci. 2016; 17 (7): 1064.

  28. Wang-Saegusa A, Cugat R, Ares O, Seijas R, Cuscó X, Garcia-Balletbó M. Infiltration of plasma rich in growth factors for osteoarthritis of the knee short-term effects on function and quality of life. Arch Orthop Trauma Surg. 2011; 131 (3): 311-317.

  29. Sánchez M, Fiz N, Guadilla J, Padilla S, Anitua E, Sánchez P, et al. Intraosseous infiltration of platelet-rich plasma for severe knee osteoarthritis. Arthrosc Tech. 2014; 3 (6): e713-e717.

  30. Cugat R, Alentorn-Geli E, Navarro J, Cuscó X, Steinbacher G, Seijas R, et al. A novel autologous-made matrix using hyaline cartilage chips and platelet-rich growth factors for the treatment of full-thickness cartilage or osteochondral defects: preliminary results. J Orthop Surg (Hong Kong). 2020; 28 (1): 2309499019887547.

  31. Cugat R, Alentorn-Geli E, Steinbacher G, Álvarez-Díaz P, Cuscó X, Seijas R, et al. Treatment of knee osteochondral lesions using a novel clot of autologous plasma rich in growth factors mixed with healthy hyaline cartilage chips and intra-articular injection of PRGF. Case Rep Orthop. 2017; 2017: 8284548.

  32. Ip HL, Nath DK, Sawleh SH, Kabir MH, Jahan N. Regenerative medicine for knee osteoarthritis - the efficacy and safety of intra-articular platelet-rich plasma and mesenchymal stem cells injections: a literature review. Cureus. 2020; 12 (9): e10575.

  33. Dwyer T, Chahal J. Editorial commentary: injections for knee osteoarthritis: Doc, You Gotta Help Me! Arthroscopy. 2021; 37 (4): 1288-1289.

  34. Lana JFSD, da Fonseca LF, Macedo RDR, Mosaner T, Murrell W, Kumar A, et al. Platelet-rich plasma vs bone marrow aspirate concentrate: An overview of mechanisms of action and orthobiologic synergistic effects. World J Stem Cells. 2021; 13 (2): 155-167.

  35. Dallo I, Rivarola HF, Collazo C, Chahla J, Gobbi A. Terapias biológicas en artroscopia de rodilla. De las ciencias básicas a la aplicación clínica. Artroscopia. 2020; 27 (2): 1-4.

  36. Collins T, Dinesh A, Barkatali B. Plasma-rich plasma: a narrative review. EFORT Open Rev. 2021; 6: 225-235.

  37. Estrada E, Décima JL, Rodríguez M, Di Tomaso M, Roberti J. Patient-reported outcomes after platelet-rich plasma, bone marrow aspirate, and adipose-derived mesenchymal stem cell injections for symptomatic knee osteoarthritis. Clin Med Insights Arthritis Musculoskelet Disord. 2020; 13: 1179544120931086.

  38. Szwedowski D, Dallo I, Irlandini E, Gobbi A. Osteo-core Plasty: a minimally invasive approach for subchondral bone marrow lesions of the knee. Arthrosc Tech. 2020; 9(11): e1773-e1777.

  39. Raeissadat SA, Ghazi Hosseini P, Bahrami MH, Salman Roghani R, Fathi M, Gharooee Ahangar A. The comparison effects of intra-articular injection of platelet rich plasma (PRP), plasma rich in growth factor (PRGF), hyaluronic acid (HA), and ozone in knee osteoarthritis; a one year randomized clinical trial. BMC Musculoskelet Disord. 2021; 22 (1): 134.

  40. Cuéllar RCT, Santos DD, Colunga FJL, Pérez ZM, Bravo AT, Zuáznabar VMC, et al. Utilidad de la ozonoterapia intraarticular en la osteoartrosis de rodilla asociada a sinovitis. Rev Cub de Med Fis y Rehab. 2012; 4 (2).

  41. Sconza C, Respizzi S, Virelli L, Vandenbulcke F, Iacono F, Kon E, et al. Oxygen-ozone therapy for the treatment of knee osteoarthritis: a systematic review of randomized controlled trials. Arthroscopy. 2020; 36 (1): 277-286.

  42. Mishra AK, Skrepnik NV, Edwards SG, Jones GL, Sampson S, Vermillion DA, et al. Efficacy of platelet-rich plasma for chronic tennis elbow: a double-blind, prospective, multicenter, randomized controlled trial of 230 patients. Am J Sports Med. 2014; 42 (2): 463-471.

  43. Miller LE, Parrish WR, Roides B, Bhattacharyya S. Efficacy of platelet-rich plasma injections for symptomatic tendinopathy: systematic review and meta-analysis of randomised injection-controlled trials. BMJ Open Sport Exerc Med. 2017; 3 (1): e000237.

  44. Fernández-Fairen M, Gutiérrez-Gómez J, Hernández-Vaquero D, Torres-Pérez AI, Sueiro-Fernández J. Evidencia científica de los factores de crecimiento en cirugía ortopédica y traumatología. Ortho-tips. 2014; 10 (4): 235-257.

  45. Fitzpatrick J, Bulsara MK, O'Donnell J, Zheng MH. Leucocyte-rich platelet-rich plasma treatment of gluteus medius and minimus tendinopathy: a double-blind randomized controlled trial with 2-year follow-up. Am J Sports Med. 2019; 47 (5): 1130-1137.

  46. Masquelet A, Kanakaris NK, Obert L, Stafford P, Giannoudis PV. Bone repair using the Masquelet technique. J Bone Joint Surg Am. 2019; 101 (11): 1024-1036.

  47. Mendieta ATR, Alvarado SJC, Negrete CJ. Utilidad del plasma rico en plaquetas y factores de crecimiento en defectos óseos, experiencia en el Hospital Regional Lic. Adolfo López Mateos del ISSSTE. Acta Ortop Mex. 2007; 21 (5): 256-260.

  48. Muthu S, Jeyaraman M, Chellamuthu G, Jeyaraman N, Jain R, Khanna M. Does the intradiscal injection of platelet rich plasma have any beneficial role in the management of lumbar disc disease? Global Spine J. 2021; 2192568221998367.

  49. Kirchner F, Pinar A, Milani I, Prado R, Padilla S, Anitua E. Vertebral intraosseous plasma rich in growth factor (PRGF-Endoret) infiltrations as a novel strategy for the treatment of degenerative lesions of endplate in lumbar pathology: description of technique and case presentation. J Orthop Surg Res. 2020; 15 (1): 72.

  50. Desai MJ, Mansfield JT, Robinson DM, Miller BC, Borg-Stein J. Regenerative medicine for axial and radicular spine-related pain: a narrative review. Pain Pract. 2020; 20 (4): 437-453.

  51. Ye L, Wen C, Liu H. Ultrasound-guided versus low dose computed tomography scanning guidance for lumbar facet joint injections: same accuracy and efficiency. BMC Anesthesiol. 2018; 18 (1): 160.

  52. Aufiero D, Vincent H, Sampson S, Bodor M. Regenerative injection treatment in the spine: review and case series with platelet rich plasma. J Stem Cells Res, Rev & Rep. 2015; 2 (1): 1019.

  53. Navani A, Manchikanti L, Albers SL, Latchaw RE, Sanapati J, Kaye AD, et al. Responsible, safe, and effective use of biologics in the management of low back pain: American Society of Interventional Pain Physicians (ASIPP) guidelines. Pain Physician. 2019; 22 (1S): S1-S74.

  54. Wu J, Zhou J, Liu C, Zhang J, Xiong W, Lv Y, et al. A Prospective study comparing platelet-rich plasma and local anesthetic (LA)/corticosteroid in intra-articular injection for the treatment of lumbar facet joint syndrome. Pain Pract. 2017; 17 (7): 914-924.

  55. Kirchner F, Anitua E. Intradiscal and intra-articular facet infiltrations with plasma rich in growth factors reduce pain in patients with chronic low back pain. J Craniovertebr Junction Spine. 2016; 7 (4): 250-256.

  56. Ruiz-Lopez R, Tsai YC. A Randomized double-blind controlled pilot study comparing leucocyte-rich platelet-rich plasma and corticosteroid in caudal epidural injection for complex chronic degenerative spinal pain. Pain Pract. 2020; 20 (6): 639-646.

  57. Ling JF, Wininger AE, Hirase T. Platelet-rich plasma versus corticosteroid injection for lumbar spondylosis and sacroiliac arthropathy: a systematic review of comparative studies. Cureus. 2021; 13 (3): e14062.

  58. Lin MT, Wei KC, Wu CH. Effectiveness of platelet-rich plasma injection in rotator cuff tendinopathy: a systematic review and meta-analysis of randomized controlled trials. Diagnostics (Basel). 2020; 10 (4): 189.

  59. Sheean AJ. Editorial commentary: platelet-rich plasma has advantages over corticosteroid for nonoperative treatment of rotator cuff pathology: another step in the right direction. Arthroscopy. 2021; 37 (2): 518-520.

  60. Enríquez JA, García A, Pastrana F, López Valero A, González A, Romo FJ. Tratamiento de las rupturas crónicas del Tendón de Aquiles con plastia de Christensen-Silverskjiold utilizando tejido fibroso como puente. Rev Mex Ortop Trauma. 2002; 16 (3): 119-123.

  61. Trams E, Kulinski K, Kozar-Kaminska K, Pomianowski S, Kaminski R. The clinical use of platelet-rich plasma in knee disorders and surgery-a systematic review and meta-analysis. Life (Basel). 2020; 10 (6): 94.

  62. Zou G, Zheng M, Chen W, He X, Cang D. Autologous platelet-rich plasma therapy for refractory pain after low-grade medial collateral ligament injury. J Int Med Res. 2020; 48 (2): 300060520903636.

  63. Yoshida M, Marumo K. An autologous leukocyte-reduced platelet-rich plasma therapy for chronic injury of the medial collateral ligament in the knee: a report of 3 successful cases. Clin J Sport Med. 2019; 29 (1): e4-e6.

  64. Barastegui D, Alentorn-Geli E, Gotecha D, Rius M, Navarro J, Cuscó X, et al. Treatment of partial posterior cruciate ligament injuries with platelet-rich plasma in growth factors (PRGF) intraligamentous infiltration and a specific knee brace. Surg J (N Y). 2021; 7 (1): e30-e34.

  65. Varon D, Spectre G. Antiplatelet agents. Hematology Am Soc Hematol Educ Program. 2009, 267-272.

  66. Schippinger G, Prüller F, Divjak M, Mahla E, Fankhauser F, Rackemann S, et al. Autologous platelet-rich plasma preparations: influence of nonsteroidal anti-inflammatory drugs on platelet function. Orthop J Sports Med. 2015; 3 (6): 2325967115588896.

  67. Bausset O, Magalon J, Giraudo L, Louis ML, Serratrice N, Frere C, et al. Impact of local anaesthetics and needle calibres used for painless PRP injections on platelet functionality. Muscles Ligaments Tendons J. 2014; 4 (1): 18-23.




2020     |     www.medigraphic.com